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606,025 grants found
Showing 36,001 – 36,020 of 606,025 grants
Reaching Non-Four-Year College Emerging Adults with Brief Alcohol Interventions: An Investigation of Service User Preferences and Implementation Determinants
PROJECT SUMMARY / ABSTRACT In the United States, emerging adults consume alcohol at higher rates than people in any other age group. Relative to four-year college students and grad...
Identifying placental tissue tropism and cellular mechanisms of Ebola Virus transmission from mother to fetus in pregnancy
Project Abstract Maternal viral infections during pregnancy may result in catastrophic outcomes for her health as well as for her developing fetus. Recent emerging virus epidemics...
A total school approach using safeguarding to address HIV-related stigma and discrimination in boarding schools in Zambia
PROJECT SUMMARY HIV-related stigma and discrimination operate at multiple socioecological levels and are known obstacles to optimal health and HIV outcomes. In Zambia, some boardin...
Adaptation and evaluation of an intersectional stigma reduction intervention to increase HIV care engagement among women who use drugs
PROJECT SUMMARY The goal of this R01 proposal is to adapt and pilot an intervention to reduce individual-level intersectional HIV/AIDS and drug use stigma and increase retention in...
Kabawil: Adapting an Intervention to Reduce Intersectional Stigmas among Indigenous Sexual Minority Men and Traditional Healers in Mesoamerica
SUMMARY/ABSTRACT During the past decade in Latin America, new yearly HIV infections rose 21%, and as of 2022, HIV infections were still rising. Of the 3.8 million people living wit...
Cluster Randomized controlled trial of Using PrEP, Doing it for Ourselves [UPDOs] Protective Styles: A salon-based intervention to improve PrEP uptake among Black cis-gender women.
HIV disproportionately affects Black cisgender women living in the United States south threatening progress toward the Ending the HIV Endemic initiative's 2030 goals. Although...
Modeling non-additive genetic mechanisms for complex traits
Project Summary A central question in the genetics of complex traits is understanding how variation in DNA sequences leads to variation in phenotype. Recent technological advances...
Adolescent brain maturation and psychopathology
Healthy adolescent brain maturation involves several highly coordinated processes including extensive and dynamic reorganization of structural and functional networks and neuropil...
An Ancient Neural Enhancer that has Rapidly Evolved in the Human Lineage
The distinctive features of humanity—our intelligence, creativity, language, as well as our ecological and demographic success—are thought to be the result of evolutionary changes...
Collaborative to understand impacts of early preventive interventions on suicide and overdose mortality using data harmonization methodology
Project Summary The goal of this application, submitted in response to RFA-MH-23-275, “Using Secondary Data Analysis to Determine Whether Preventive Interventions Implemented Earli...
Identifying Developmental and Degenerative Mechanisms of SMA Using Single Motor Neuron Nucleus RNA Sequencing
PROJECT SUMMARY Spinal muscular atrophy is a monogenic motor neuron disease and is historically a leading inherited cause of death in infancy and childhood. While development of SM...
Demographic and Health Effects of Climate Exposures Across the Life Course
PROJECT SUMMARY This project will measure how exposures to climatic variability (i.e., temperature and precipitation anomalies) during early-life and adolescence affect the fertili...
Improving Shared Decision Making in Early use of Neurotechnologies Across Different Disease Stages
ABSTRACT Recent research emphasizes the opportunities of using neurotechnology earlier in the disease progression. However,earlier use of neurotechnology also raises significant et...
Task-Shifting: Brief Interpersonal Psychotherapy by Youth Mentors for Latinx Youth Suicide Prevention
SUMMARY ABSTRACT In the last ten years, Latinx youth reports of poor mental health (30%), sadness, hopelessness (46%), and suicide ideation (22%) have significantly increased. Suic...
Large-scale integrated data analysis of lymphocyte receptor repertoires with workflows
Project Summary / Abstract Over the last decade, high-throughput B cell and T cell receptor repertoire sequencing has become a fundamental method for investigating adaptive immune...
Harnessing Redox Regulation of Proteasome Function to Promote Healthy Aging
PROJECT SUMMARY For half a century, groups across the world have been investigating the hypothesis that reactive oxygen species influence the biology of aging. However, technical l...
Remote monitoring using commercially available activity trackers and computer vision provides a holistic, low-cost assessment of Parkinson’s disease symptoms
Although there has been considerable interest in using remote monitoring in diseases like Parkinson’s disease, Alzheimer’s disease, and other Alzheimer’s disease-related dementias,...
Application of precision medicine to phototherapy: a stepped care approach to consolidate sleep and slow cognitive decline in older adults
PROJECT SUMMARY/ABSTRACT While consolidated sleep is crucial for healthy cognition and mood in older individuals, many suffer from sleep- wake fragmentation, a risk factor for deve...
The Personalized Remote Radiation Tracking Portable Organ Dosimetry Devise (PRRT PODD)
Theranostics is a type of precision medicine in which targeted radiolabeled compounds are being used for both diagnosis and treatment. Targeted therapies can increase therapeutic e...
Molecular and bioenergetic dynamics of in utero chronic hypoxia on placenta and brain
PROJECT SUMMARY Insufficiency of the placenta due to conditions such as hypertension, diabetes, and fetal congenital heart disease can lead to chronic in utero hypoxia. Chronic hyp...