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Identifying, Validating, and Characterizing Biological Subtypes of PsychiatricDisorders Using a Novel Computational Framework
PROJECT SUMMARY Biologically-grounded data-driven stratification of disease has revolutionized most of modern medicine. Yet, psychiatric disorders—a major public health concern—are...
Role of PGM-3 and SPE-56 in fertilization and egg activation
Project Summary/Abstract Infertility impacts one in five couples globally. For many of these couples, the sperm and egg look morphologically normal. This complicates determining tr...
Active HCV diagnosis to support prevention of HCC in LMICs
Project Summary HCV is a major threat worldwide, infecting over 58 million people and causing 300,000 deaths from HCV-related cirrhosis or hepatocellular carcinoma (HCC) each year....
Home-based Digital Technologies: A Translational Approach to Support Aging-in-Place for Rural African-Americans with Alzheimer’s Disease and their Care Partners
PROJECT SUMMARY Candidate and Career Development Plan: This REDI Mentored Entrepreneurial Career Development Award (K01) will support Otis (Shaun) Owens, Ph.D. to establish an inde...
Regulation of Androgen Receptor by NXTAR Long non-coding RNA in Prostate Cancer and its Therapeutic Implications
Abstract Androgen receptor (AR) signaling continues to play a dominant role in all stages of prostate cancer (PC), including castration-resistant prostate cancers (CRPCs) that have...
Role of LAM-specific TREM1 in leukemogenesis
PROJECT SUMMARY/ABSTRACT Cancer progression is heavily influenced by supportive cells in the tumor microenvironment. Macrophages, an important component of tissue microenvironment,...
Neural Mechanisms of Anticholinergic Burden in Mid- to Late-Life Schizophrenia Spectrum Illness
PROJECT SUMMARY Schizophrenia spectrum disorders (SSD) are associated with significant morbidity and mortality across the world. A considerable portion of healthcare and societal c...
Metals Exposure, Dementia, and Longitudinal Trajectories of Cognition, Functioning, and Neuropsychiatric Symptoms
PROJECT SUMMARY/ABSTRACT Dementia is a disorder of multiple cognitive domains severe enough to affect activities of daily living and often occurs with more than one neuropathology,...
The role of vascular failure and biomechanical stress in the development, progression and healing of osteochondritis dissecans lesions
PROJECT SUMMARY/ABSTRACT Ostechondritis dissecans (OCD) is a developmental orthopaedic disease affecting children and young adults. It is characterized by formation of osteochondra...
Development of a Direct Diagnostic Test for Infectious and Congenital Syphilis
PROJECT SUMMARY Current diagnostic tests for syphilis are non-optimal, in that they cannot differentiate active from past infection, cannot diagnose congenital syphilis, and have l...
Molecular mechanisms underlying sub-thalamic influences on extinction learning
PROJECT SUMMARY. The expression of debilitating fear toward stimuli previously associated with trauma even after they no longer pose a threat is a core pathology of Post-Traumatic...
Defining Sjögren’s pathogenesis by endotype: maladaptive responses of endogenous salivary gland mesenchymal stromal cells
Sjögren's disease (SjD), a common systemic autoimmune disease characterized by severe oral and ocular dryness and multi-organ involvement, has no disease modifying treatment a...
Transitional Care for Skilled Nursing Facility Patients with Alzheimer’s Disease and Related Dementias and their Caregivers: a Cluster Randomized Trial.
Project Summary/Abstract Every year 400,000 people with Alzheimer’s disease and related dementias (ADRD) are hospitalized, transfer to a skilled nursing facility (SNF), and transit...
Narrowing the mechanistic gap for anterior prefrontal cortex function
PROJECT SUMMARY Prefrontal cortex (PFC) is a large and heterogeneous brain area comprising the front third of the human brain that has been implicated in numerous mental health dis...
Blood Trauma, Vascular Remodeling, and Vasoregulation with Total Body Continuous Versus Pulsatile Artificial Circulation
Project Abstract Left ventricular assist device support is standard therapy for patients with advanced, life-threatening heart failure. However, current-generation impeller-based b...
Investigation of Cardiac Arrhythmias in TANGO2 Disorder
ABSTRACT TANGO2 Deficiency Disorder is an autosomal recessive disease caused by genetic alterations in TANGO2 (Transport and Golgi Organization Homolog 2). Patients, primarily youn...
Direct characterization and correction of circuit level computational deficits underlying compulsivity in humans
PROJECT SUMMARY Compulsivity, persisting with set ways of thinking and behaving in the face of negative consequences, is a prominent component of multiple psychiatric disorders. Gi...
Examining the influence of sociodemographic and medical factors on plasma p-tau217 performance in diverse communities
ABSTRACT. Alzheimer’s disease (AD) is a public health crisis that disproportionately affects individuals in the Black community. With recent advances in treatment, the need for ear...
Culturally tailoring a mindfulness meditation mobile app to reduce psychological distress in African American adults
Project Summary/AbstractThis K01 is a mixed methods research project in collaboration with an industry partner (i.e., Healthy Minds Innovations)and will be conducted across three a...
Long-term effects of universal health insurance in developing countries: Evidence from Mexico
Project Title Long-term effects of universal health insurance in developing countries: Evidence from Mexico Project Summary/Abstract (30 lines of text) The implementation of govern...