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606,025 grants found
Showing 35,781 – 35,800 of 606,025 grants
Pharmacokinetics and Pharmacodynamics of Mechanistically Aware Phage Cocktails
ABSTRACT: With only one mechanistically novel antibiotic developed in the past decade with activity versus resistant Gram-negatives, extensively-drug resistant Pseudomonas aerugino...
Predicting Clinical Deterioration in Mechanically Ventilated Children using High-Frequency Physiologic Data
PROJECT SUMMARY Significance: Clinical deterioration in the PICU, as defined by new or progressive organ dysfunction, occurs in up to 5% of critically ill children during their fir...
Effects of enriched parent-infant interaction on health in early life
PROJECT SUMMARY Early life experiences, such as those associated with stable attachment, supportive relationships, and nurturing environments, have profound effects on lifelong phy...
Repurposing Ferumoxytol Nanoparticles to Promote Orofacial Stem Cell Function for Autotherapies
Project Description The advancement of regenerative medicine has provided many new potential treatments for craniofacial bone defects, in which mesenchymal stem/progenitor cells (M...
Ketone supplementation as an intervention to alleviate alcohol withdrawal and improve brain energetics in Alcohol Use Disorder
PROJECT SUMMARY/ABSTRACT Alcohol Use Disorder (AUD) is a chronic, relapsing brain disorder that accounts for 5% of deaths globally. There is an urgent need to test interventions th...
Integrative Analysis and Visualization Platform for Cancer Regulatory Genomics
PROJECT SUMMARY Recent advancements in next-generation sequencing technologies have resulted in the generation of vast quantities of publicly accessible data that are specific to c...
Uncovering the functional and mechanistic dysregulation of monocytes after abstinence and post-abstinence drinking
Over 85% of individuals 18-years and older within the United States (US) consume alcohol. More importantly, a staggering 25.8% and 6.3% are classified by the National Institute on...
Exploring the function of novel arginine phosphorylation in streptococcal physiology
ABSTRACT Post-translational modification (PTM) by phosphorylation plays an important role in protein folding, stability, and function. In bacteria, protein phosphorylation plays a...
Sphingomyelin Metabolism Impacts on Crystalline Silica-Induced Outcomes
Abstract There are numerous examples of endogenous and exogenous particle-induced chronic inflammation. One model of chronic environmentally-induced inflammation is driven by expos...
Everyday Aesthetic Value
Understanding the nature of aesthetic value is important because it forms a big part of what makes our lives worth living. In the last 10-15-years, there has been an upsurge of int...
Reconstructing 200 years of genetic history in European wolves
Wolves are an important apex predator species, and their conservation in Europe has been a key concern since their population collapse at the beginning of the 20th century.Increase...
A multi-institutional validation study of predicting prostate cancer-specific mortality with AI-based grading
Purpose and goal:Treatment decisions for prostate cancer, one of the world´s most common cancers, are primarily based on subjective histopathological grading according to Gleason....
R2R-HET -Roll-to-roll Hybrid Printed Electronics Manufacturing
Purpose and goal:The project aims to develop and validate a concept that enables and establishes a state-of-the-art, roll-to-roll production capacity in Sweden that can handle both...
Laser ultrasonics for non-destructive battery weld evaluation (LUNAR)
Purpose and goal:This project aims to explore the feasibility of using laser ultrasound (LUS) as a non-destructive and efficient method for measuring the welded area of laser welds...
AI-TOMO: Accelerated materials characterisation by AI and X-ray tomography
Purpose and goal:The purpose of the project is to accelerate characterisation of materials structures by AI and X-ray tomography to facilitate development of new sustainable produc...
National Accelerator Program for Civil-Military Synergies
Purpose and goal:The purpose of the application is to implement a pilot of a robust and effective accelerator program that strengthens cooperation between civil and military actors...
Capacity-building for Regional and National Innovation Ecosystem Development
Purpose and goal:The overall purpose of the project is to strengthen the capacity for regional innovation ecosystems in Sweden to adopt a coordinated ecosystem approach to regional...
CD8+ T CELL REPROGRAMMING TO BOOST ANTIVIRAL POTENTIAL AGAINST CHRONIC INFECTION
PROJECT SUMMARY/ABSTRACT There is substantial evidence that stem-like CD8+ T cells have a central role in the natural control of chronic viral infection. For example, virus-specifi...
State social policy interventions for maternal health
Project Summary Poverty is the most widely studied fundamental determinant of maternal mental health, morbidity, mortality, and inequities in the U.S. and worldwide. Low absolute a...
Modulating growth, progression and metastasis in breast cancer by inhibiting MDA-9
Despite therapeutic advances, the 5-year survival rate from metastatic triple negative breast cancer (TNBC) has not improved significantly for 30-years. As such, significant benefi...