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606,025 grants found
Showing 35,741 – 35,760 of 606,025 grants
Project 2: Viral entry, antibodies, and structural biology
PROJECT SUMMARY – PROJECT 2: VIRAL ENTRY, ANTIBODIES, AND STRUCTURAL BIOLOGY Studies of viral glycoproteins and their interactions with receptors and antibodies are paramount to va...
Project 3: Antigen design
PROJECT SUMMARY – PROJECT 3: ANTIGEN DESIGN Project 3 focuses on developing generalizable approaches to the modeling, design, and evaluation of native-like antigens for arenaviruse...
Project 4: Protein nanoparticle vaccines
PROJECT SUMMARY – PROJECT 4: PROTEIN NANOPARTICLE VACCINES Project 4 focuses on developing generalizable approaches to the design, production, and evaluation of two-component prote...
Project 5: mRNA and mRNA-launched nanoparticle vaccines
PROJECT SUMMARY – PROJECT 5: mRNA AND mRNA-LAUNCHED NANOPARTICLE VACCINES The goal of Project 5 is to develop generalizable approaches and platforms to design, make, and evaluate m...
Conte Center: Understanding Latent Cause Inference in Health and Illness
Conte Center – Understanding Latent Cause Inference in Health and Illness Latent cause inference is the fundamental cognitive process by which we draw boundaries between situations...
Administrative Core (A)
CORE A – Administrative Core This Conte Center – Understanding latent cause inference in health and illness – will bring together 10 highly accomplished investigators from two neig...
Project 1: Latent-cause inference as a fundamental cognitive process
PROJECT 1 – Latent cause inference as a fundamental cognitive process Latent cause inference is a fundamental cognitive process that allows us to group experiences together, so tha...
Project 2: Latent-cause inference in compulsivity
PROJECT 2 – Latent cause inference in compulsion A promising line of research has suggested that a transdiagnostic dimension of compulsive psychopathology arises from an imbalance...
Project 3: Latent-cause inference in anxiety
Exposure therapy is the most effective evidence-based treatment for a variety of anxiety disorders, but relapse is common. Failures of exposure therapy can be explained in part by...
Behavioral Testing and Clinical Assessment Core (B)
CORE B – Behavioral testing and clinical assessment The overarching aim of Core B is to provide a harmonized infrastructure for human subjects research in support of Projects P1-P3...
Computational Modeling Core (C)
CORE C – Computational Modeling Core The computational modeling core will provide computational model development and model-based data analysis tools for all the Projects in the Ce...
Neuroimaging Core (D)
CORE D – Neuroimaging Core Functional MRI (fMRI) and advanced multivariate analysis techniques are essential methods for achieving the aims of this Conte Center proposal. The overa...
Flavivirus and Alphavirus ReVAMPP (FLARE)
SUMMARY. The Flavivirus and Alphavirus ReVAMPP (FLARE) Center will develop and optimize protein nanoparticle, virion-based, and mRNA vaccine platforms, and monoclonal antibody (mAb...
Core A: Administrative
Core A (Administrative Core) Summary The Administrative Core A (hereafter, Core A) will serve as the central entity to direct, oversee, and ensure the mission of the Flavivirus and...
Core B: Data Management
Summary, Data Mangement Core B The Data Management Core B (hereafter, Core B) will be the nexus for all data management, analysis, and harmonization activities in the Flavivirus an...
Core C: Structure, Computational, Protein Engineering
SUMMARY Flaviviruses and alphaviruses are enveloped, single-stranded RNA viruses that cause epidemics of human disease on a global scale, with new virus members regularly emerging...
Core D: Animal Immunogenicity and Challenge
SUMMARY Flaviviruses and alphaviruses are emerging arthropod-borne viruses that cause severe and often life-threatening disease in humans, and ongoing and recent epidemics have inf...
Core E: Correlates of Protection
Flaviviruses and alphaviruses are enveloped, single-stranded RNA viruses that cause epidemics of human disease on a global scale, with new family members regularly emerging and cau...
Project 1: Vaccine Design Neurotropic Flaviviruses
SUMMARY Emerging and re-emerging arthropod-vectored viruses pose a significant threat to human health. Tick- and mosquito-transmitted viruses can cause encephalitis and hemorrhagic...
Project 2: Vaccine Design Epidemic Flaviviruses
SUMMARY Arthropod vector-borne flaviviruses threaten the health of people in nearly all countries of the world. Over the past 30-years, the epidemiology of flaviviruses has been ch...