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606,025 grants found
Showing 35,801 – 35,820 of 606,025 grants
Brainstem glial senescence and dysfunction in obesity-induced hypertension
Elevated sympathetic nerve activity (SNA) mediates the increased risk for hypertension and heart failure in obesity. Yet the mechanisms that contribute to obesity-induced increases...
Development and Psychometric Evaluation of Gastrointestinal Symptom Measures in Autistic Children and Adults
PROJECT SUMMARY/ABSTRACT Gastrointestinal (GI) symptoms appear to be common and disabling in children and adults on the autism spectrum. Co-occurring GI symptoms are associated wit...
Investigating Novel HIV Reservoirs in the Pulmonary Vasculature
PROJECT SUMMARY Infections with Human Immunodeficiency Virus (HIV) remain a major global public health concern. The HIV reservoirs are a leading reason for which HIV infection rema...
Generation of highly differentiated NK cells to synergize with broadly neutralizing antibodies to establish viral control in absence of ART
ABSTRACT/SUMMARY A distinguishing feature of SIV infection in African green monkeys (AGMs), a natural host species for SIV, is the absence of viral dissemination in the lymphoid B-...
Exploring sustained implementation and fidelity of an evidence-based HIV prevention program
The importance of – and difficulty in – sustaining implementation, with fidelity, of effective HIV interventions is well recognized. Our research partnership of >20-years in The...
Investigating the redox-sensitive E3 ubiquitin ligase Pellino-1 as a driver of T-cell dysfunction during severe lung infection
PROJECT SUMMARY Patients with hematologic cancer are at increased risk of morbidity and mortality from severe lung infections due to both disease and treatment-associated defects i...
Invasive trophoblast cell differentiation
PROJECT SUMMARY In the early stages of human pregnancy, cells from the developing placenta, termed extravillous trophoblast (EVT) cells, must interact with the uterus. In other spe...
Examining dietary and metabolomics patterns on cardiometabolic outcome variability in response to calorie restriction
PROJECT SUMMARY Cardiovascular disease (CVD) is the leading cause of mortality and morbidity worldwide, with age being the strongest independent non-modifiable risk factor. Calorie...
Identifying multilevel facilitators of care outcomes among Positive Deviants to design an intervention for Black sexual minority men living with HIV
Project Summary/Abstract The goal of this R01 is to build upon our sponsored Positive Deviance research by identifying how durably virally suppressed Black sexual minority men livi...
Implementing Sustainable mobile health Technology to Optimize smoking cessation Program for Lao people with HIV (I-STOP)
PROJECT SUMMARY: Tobacco use remains the leading modifiable risk factor for preventing cancer globally, particularly among people with HIV (PWH). In Lao People's Democratic Re...
Linking insufficient sleep with body weight in Black emerging adults.
PROJECT ABSTRACT Compared to peers in other racial groups, Black emerging adults (18-28-years old) have the highest risks of short sleep duration and cardiovascular disease. This i...
Stem-like T cells as bioindicators and orchestrators of the disease process in MS and animal models
There is an urgent need for a better understanding of the propagation of encephalitogenic autoimmune responses and the identification of relevant immune cells and their specific ch...
Investigating the Role of Macrophages in Heart Failure with Preserved Ejection Fraction
CHALLENGE: Heart failure with preserved ejection fraction (HFpEF) is a complex clinical syndrome that presents with heart failure symptoms, unaltered left ventricular ejection frac...
Using miRNA to identify new therapeutic pathways for dilated cardiomyopathy
SUMMARY Dilated cardiomyopathy (DCM) associated heart failure is a leading cause of death and new therapeutic strategies are needed. Pathogenic variants in over 50 genes contribute...
Structural consequences of PKC-dependent phosphorylation of Kv7.2
Project Summary M channels are critical for regulating the excitability of neurons. Dysfunction of M channel activity can cause epilepsy. While M channels have been intensely studi...
PRomoting Excellence through Pain and Addiction Research Enhancement (PREPARE)
ABSTRACT Pain and substance use disorders (SUD) represent arguably the two most prevalent and costly public health condition in the United States. While vitally important to consid...
Helping Protect Armenians' Rights Together Project
The project aims to improve the government's enforcement and promotion of labor laws and standards that are consistent with international labor standards, in one or more speci...
Technical Assistance for Banking & Financial Services - Barbados 01
Technical Assistance for Banking & Financial Services - Barbados 01
Feasibility Study - Sao Paulo Rail ICT Integration, through CelPlan Technologies, Inc.
This feasibility study grant provides funding to recommend ICT solutions for Sao Paulo's Companhia Paulista de Trens Metropolitanos (CPTM).This feasibility study will create o...
USAID Miscellaneous Goods, Services, and Operations Maintanence
Administrative costs and operating expenses of USAID contributing to Miscellaneous Goods, Services, and Operations Maintanence.