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606,025 grants found
Showing 35,721 – 35,740 of 606,025 grants
Engaging Mental Health Services for Preschoolers at Risk
PROJECT SUMMARY/ABSTRACT Most mental health (MH) disorders develop in early childhood but are not clinically identified or treated until later—delaying treatment services that coul...
Federal Housing Assistance and Birth Outcomes in the United States
PROJECT SUMMARY Adverse birth outcomes, including prematurity and low birthweight, are a persistent public health problem in the United States. They affect nearly half a million ne...
THRIVE-DM: Improving Diabetes Care with Strategies for Addressing Health-Related Social Needs and Community Partnerships
PROJECT SUMMARY/ABSTRACT We propose to implement and assess THRIVE-DM, an expansion of our existing THRIVE health-related social needs (HRSN) screening and referral program, with t...
A Triad Approach Towards Improved Diagnostics for Maternal and Congenital Syphilis
Project Summary Syphilis is a sexually and vertically transmitted disease caused by Treponema pallidum subspecies pallidum (TPA). While adult syphilis is often asymptomatic and sel...
Effects of maternal exercise on fetal akinesia-impaired bone and joint development
Abstract Mechanical forces exerted by fetal movement during development influence skeletal morphogenesis. Thus, fetal akinesia (insufficient movement), caused by low amniotic fluid...
Elucidating the mechanism of Ga13 mediated tumor suppression in pancreatic cancer
RESEARCH SUMMARY The heterotrimeric G proteins transduce signals from the G protein-coupled receptors (GPCRs), the largest class of cell surface proteins that regulate a wide varie...
What drives disease caused by inherited heteroplasmic pathogenic mtDNA variants?
Disease caused by inherited mitochondrial (mt)DNA mutations is clinically heterogeneous; individuals carrying the same pathogenic variant can have very different phenotypic present...
Core 1: Lymphoma models
CORE 1 LYMPHOMA MODEL SYSTEMS: SUMMARY/ABSTRACT The Lymphoma Model System core (LMSC) will assemble and characterize the reagents critical for this proposal, including the vast arr...
Biostatistics and Computational Biology (BCB) Core
CORE 2: BIOSTATISTICS AND COMPUTATIONAL BIOLOGY: SUMMARY/ABSTRACT The Biostatistics and Computational Biology (BCB) Core for this P01 will enable cost-effective data processing, an...
Core 3: MPIP.
CORE 3_MULTIPARAMETER IMAGING AND PATHOLOGY: SUMMARY/ABSTRACT One basic function of Core 3 includes the collection and distribution of specimens and patient samples to P01 investig...
3D In vivo dosimetry for FLASH proton therapy
ABSTRACT: This U01 application aims to (1) develop a robust protoacoustic dosimeter for 3D in vivo dosimetry in proton FLASH therapy, which is essential for its clinical applicatio...
Nonlinearities in Human Vestibular Reflexes
Project Summary/Abstract The long-term goal of our research program is to assess the natural disease state of age-related changes in the vestibular system and improve clinical diag...
CD79A as a molecular switch regulating B cell activation
B lymphocytes are critical players in the development of protective immunity, as well as in pathological states such as autoimmunity. Careful regulation of the strength and quality...
Machine learning-enabled design of prototype pathogen vaccines and antibodies
PROJECT SUMMARY – OVERALL: MACHINE LEARNING-ENABLED DESIGN OF PROTOTYPE PATHOGEN VACCINES AND ANTIBODIES We propose a highly synergistic Center focused on developing end-to-end str...
Core A: Administrative
PROJECT SUMMARY – CORE A: ADMINISTRATIVE The Administrative Core will coordinate the scientific, administrative, and financial functions of our multi-project, multi-institution Cen...
Core B: Data Management
PROJECT SUMMARY – CORE B: DATA MANAGEMENT The Data Management Core will create, operate, and maintain state-of-the-art computer systems to store and safeguard the diverse types of...
Core C: Vaccine production and process development
PROJECT SUMMARY – CORE C: VACCINE PRODUCTION AND PROCESS DEVELOPMENT The Vaccine Production and Process Development Core will provide both high-throughput and scalable biologics pr...
Core D: Animal models and vaccine evaluation
PROJECT SUMMARY – CORE D: ANIMAL MODELS AND VACCINE EVALUATION Among viruses that cause disease in humans viral zoonoses within the family Paramyxoviridae and order Bunyavirales co...
Core E: Phylogenetic and mutational scanning
PROJECT SUMMARY – CORE E: PHYLOGENETIC AND MUTATIONAL SCANNING This Core will use cutting-edge experimental and computational techniques to ensure that the vaccines target the full...
Project 1: Computational methods
PROJECT SUMMARY – PROJECT 1: COMPUTATIONAL METHODS Project 1 will develop the general computational methods that underpin our Center’s approaches to vaccine and antibody design. In...