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606,025 grants found
Showing 35,241 – 35,260 of 606,025 grants
An Ultrasensitive Flow Cytometry System for Multiparametric Analysis of Therapeutic Anti-Aging Extracellular Vesicles
PROJECT SUMMARY Extracellular vesicles (EVs) are small, lipid bound vesicles that are secreted by cells. Originally thought to serve little purpose, EVs have been gaining significa...
Developing an Integrated Brain State Monitor for Personalized Anesthesia Decision Support: Preventing Postoperative Delirium in Elderly and Patients At Risk for Alzheimer's or Related Dementias
Each day, more than 100,000 patients undergo general anesthesia in the United States. 40 percent of the patients receiving anesthesia care are 60-years or older. Post-operative del...
Engineering ex vivo breast tumors in human breast tissue to address racial disparities in HR-/ERBB2+ breast cancer
PROJECT SUMMARY/ABSTRACT Black women are 42% more likely to die from breast cancer than White women. While social, economic, structural, and cultural factors contribute to this dis...
Tesamorelin as an Adjunct to Exercise for Improving Physical Function in HIV (TRIUMPH)
Project Summary/Abstract With the advent of modern antiretroviral therapy, life expectancy in people with HIV (PWH) now approaches that of the general population. Nonetheless, PWH...
Tracking myeloid heterogeneity in mouse models and cerebrospinal fluid of HIV-suppressed individuals to classify neuroinflammation and identify molecular markers associated with clinical pathology
PROJECT SUMMARY/ABSTRACT A major problem in virally suppressed people with human immunodeficiency virus (VS-PWH) is that despite well- controlled viral suppression many patients de...
Characterizing longitudinal post-acute rehabilitation utilization and outcomes during the first year after stroke in Medicare beneficiaries
PROJECT SUMMARY/ABSTRACT I am seeking a Mentored Research Scientist Development Award (K01) in order to acquire the necessary training, practical experience, and knowledge to becom...
Human‐specific vulnerabilities and compensatory adaptations to age‐related stressors in selectively vulnerable midbrain dopaminergic neurons
PROJECT SUMMARY The evolutionary expansion of the brain along the primate lineage involved unequal scaling of brain regions, with telencephalon size increasing dramatically more th...
RBC Effects on Neutrophil Activation and Phenotypes in Sickle Cell Disease
Project Summary/Abstract Increasing evidence suggests that activated neutrophils play a critical role in promoting vaso-occlusion and morbidity in sickle cell disease (SCD). Multip...
Coordinating Center for Primate Aging Research
SUMMARY The Tulane National Primate Research Center (TNPRC), California National Primate Research Center (CNPRC), and Baylor College of Medicine (BCM) present a unique combination...
Cellular and circuit adaptations contributing to the incubation of oxycodone craving
PROJECT SUMMARY Recently, opioid use and dependence has increased to epidemic levels. A prominent contributor to this trend is oxycodone, (Oxy), a semisynthetic opioid analgesic an...
Impact of new tobacco product design and synthetic additives on use initiation and preference behavior
The tobacco industry has been rapidly introducing products with novel designs and constituents, in response to regulatory interventions, to maintain nicotine dependence in people w...
Quality Measures to Advance Suicide Prevention and Care Across Health Systems
PROJECT SUMMARY / ABSTRACT Suicide accounted for >48,000 deaths in the United States (US) in 2021. The annual rate has increased by >34% in the last 20-years. Suicide prevent...
Dissecting the thermosensory biology of soil-transmitted parasitic nematodes
PROJECT SUMMARY Soil-transmitted parasitic nematodes infect over a billion people around the world and can cause devastating and sometimes fatal illness. Despite this massive healt...
The molecular basis of ferrosome organelle biogenesis and its impact on host-microbe interactions
SUMMARY Clostridioides difficile, a Gram-positive, spore-forming anaerobic bacterium, is the leading cause of nosocomial and antibiotic-associated intestinal infections in the Unit...
Acquisition of a Leica high pressure freezer for the cryo-based electron microscopy techniques
PROJECT SUMMARY / ABSTRACT Funds are requested to purchase a Leica EM ICE high-pressure freezer to prepare electron microscopy samples for projects focused around mental health res...
Understanding the role of the blood vascular system and endothelial cells in early thymus regeneration after cytotoxic treatments using novel intravital imaging techniques
PROJECT SUMMARY Hematopoietic cell transplantation (HCT) remains an important treatment for hematologic malignancies such as multiple myeloma, lymphoma, acute leukemias, and myelod...
Mapping and modeling inhibitory interneurons in Alzheimer's disease and related dementias: novel strategies to reverse neural network dysfunction
ABSTRACT Alzheimer’s disease (AD) and AD-related dementias (ADRD) are prevalent and costly, with no disease-modifying therapies. Emerging data demonstrate that disruptions within i...
Establishing if Music Engagement is a Protective Factor in Adolescent Substance Use Using Existing Longitudinal, Genetic, and Environmental Datasets
PROJECT SUMMARY / ABSTRACT. Substance use disorders affect millions of Americans, with substance use often beginning in adolescence. There is a pressing need to identify targets fo...
The Role of Reproductive Aging for Racial Differences in AD/ADRD from Midlife to Older Age
PROJECT SUMMARY The prevalence of Alzheimer’s Disease and Alzheimer’s Disease-Related Dementias (AD/ADRD) is predicted to nearly triple to 152.8 million cases worldwide by 2050. Wo...
Dementia caregiving and the cognitive science of surrogate decisions
PROJECT SUMMARY/ABSTRACT Decision-making by and on behalf of people with dementia poses especially complex clinical, ethical and policy problems. Addressing these complexities will...