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606,025 grants found
Showing 35,281 – 35,300 of 606,025 grants
Connexin 43 drives glioblastoma cancer stem cells through a WNK1 signaling axis
ABSTRACT Glioblastoma, the most common primary malignant brain cancer, remains uniformly fatal despite current standard of care consisting of maximal safe surgical resection follow...
UIC Animal Facility Environmental Monitoring System
Project Summary The enclosed application seeks to enhance the animal housing facilities at the University of Illinois Chicago (UIC). UIC's animal care and use program consists...
Neural Mechanisms of Menstrual Cycle Effects on ADHD and Cognition
ABSTRACT Attention-Deficit/Hyperactivity Disorder (ADHD) is increasingly recognized as a serious and debilitating problem in adolescent and adult females, with impairment and comor...
IMPACT-ADRD: Investigating the Multi-omics Perturbations Associated with Complex Environmental Toxicants and their Contribution to Alzheimer's Disease and Related Dementias
Abstract Increased risks of chronic illnesses, including Alzheimer’s Disease and related dementias (AD/ADRD), have been linked to exposures to ambient air pollution, particularly f...
Human iPSC model of Cerebro-Vascular Interactions in ADRD
We propose to generate and validate a novel model that incorporates human cerebral cortical neurons and glia, vascular endothelial cells, neural crest pericytes and microglia from...
Optimal Preoperative Care for Older Adults with Inflammatory Bowel Disease (K76) - Resubmission - 1
ABSTRACT Adults 60-years and older are the fastest growing subpopulation of patients with inflammatory bowel disease (IBD), and are soon forecasted to represent >1 million indiv...
The Contribution of Structural Racism to the Long-Term Effects of Natural Disaster on Behavioral Health Outcomes (SALENDO)
ABSTRACT Black and Latinx people in the United States (US) suffer disproportionately high levels of substance use and mental health disorders. Further, racial and ethnic minoritize...
The Bidirectional Gut-Microbiota-Brain Axis in Parkinson’s disease: integrating mechanistic biomarkers of disease severity and progression
ABSTRACT In this UO1 application, the Medical College of Georgia and Rush Gastroenterology & Neurology Research Centers propose prospective cross-sectional and longitudinal stu...
Racial/Ethnic Disparities in Housing Instability, Extended Kin Resources, and Late-Life Health
Project Summary Housing is a critical social determinant of health and key contributor to racial/ethnic health disparities in the US. In the context of rising housing costs, a rece...
Brain Stiffness as a Predictor of Chronic Subdural Hematoma Characteristics and Tissue Reexpansion
PROJECT SUMMARY Chronic subdural hematoma (CSDH) is one of the most common types of intracranial hemorrhage, affecting 3.4-5/100,000 per year in the general population and 60-80/10...
Develop and Validate a Mouse Model for Alzheimer Disease in Down Syndrome
Alzheimer disease (AD) exacts enormous personal and financial burdens in the aging. People with Down syndrome (DS) (i.e., trisomy 21, HSA21) are at markedly increased risk of AD, a...
Epileptic Electrophysiological Brain Networks Modeling with Partially Observable Brain Regions
Project Summary Epilepsy is one of the most common neurological disorders, affecting 50 million people worldwide of all ages. Seizures in up to one third of epilepsy patients are d...
Hybrid Effectiveness-Implementation Trial of a School Clinician Training and Psychosocial ADHD/ODD Intervention Program Adapted for Schools across Mexico (CLS-A-FUERTE)
Neurodevelopmental disorders of Attention-Deficit/ Hyperactivity Disorder (ADHD) and Oppositional Defiant Disorder (ODD) are extremely common but underserved with Evidence-Based Tr...
Automated aquatic husbandry equipment to enable rigorous and reproducible axolotl studies
PROJECT SUMMARY: Axolotl salamanders are model organisms offering researchers unique opportunities to explore fundamental mechanisms underlying a variety of biomedically-relevant p...
Leveraging harmonized data to improve external validity and efficiency of clinical trials for treating opioid use disorder
Randomized clinical trials for the treatment of psychiatric and substance use disorders can be difficult, time- consuming, and expensive to conduct. Partially as a consequence, the...
CiLostAzol for pReventIon of recurrent sTroke in Africa (CLARITY-Africa)
PROJECT SUMMARY Global estimates suggest that sub-Saharan Africa (SSA) now has the highest incidence, prevalence, and worst survival outcomes of stroke. With an estimated 1.4 milli...
Collaborative Research: SaTC: EDU: Education on Securing AI System under Adversarial Machine Learning Attacks
Artificial Intelligence (AI) has reached groundbreaking milestones in recent years. Its usage has spanned critical application domains, such as computer vision, audio perception, a...
MRI: Equipment: A New CeBr3 Gamma-Ray Detection Array (CeBrA) for Particle-Gamma Coincidence Experiments at the FSU Super-Enge Split-Pole Spectrograph
This award provides support for Ursinus College, a primarily undergraduate institution, to upgrade the particle-gamma ray coincidence capabilities at the John D. Fox Laboratory at...
Research in Field Theory and String Theory
This award funds the research activities of Professor Sumit R. Das at the University of Kentucky.The construction of a consistent framework combining the laws of Quantum Mechanics,...
Graduate Research Fellowship Program (GRFP)
The National Science Foundation (NSF) Graduate Research Fellowship Program (GRFP) is a highly competitive, federal fellowship program. GRFP helps ensure the vitality and diversity...