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606,025 grants found
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The role of immune deregulation and NGF dysmetabolism in the development of Alzheimer disease in individuals with Down syndrome
PROJECT SUMMARY/ABSTRACT Down syndrome (DS) is a developmental genetic condition caused by trisomy of human chromosome 211-6. DS occurs in approximately 1 in 600-1000 live births a...
Investigating the Role of Adipose Senescent Cells in Cognitive Function and Alzheimer's Disease Progression
Investigating the Role of Adipose Senescent Cells in Cognitive Function and Alzheimer's Disease Progression Abstract Alzheimer's disease (AD) is an incurable neurodegener...
Integrated Training Program in Vaccinology (ITP-Vax)
PROJECT SUMMARY Vaccination has had a profound impact on human health and has eradicated or almost eradicated once feared diseases such as smallpox and polio and substantially decr...
Neuroimaging and clinical Endpoints With High-dimensional analysis Of Pathological Endophenotypes in TBI (NEW-HOPE-TBI)
Project Summary/AbstractAlzheimer’s disease and related dementias (ADRDs) are highly prevalent, devastating to patients and their loved ones, and encompass a diversity of etiologie...
Robot-based Information and Support to Enhance Alzheimer's Caregiver Health (RISE)
Project Summary/Abstract The burden of caring for persons with Alzheimer's disease and related dementias (PwADRD) often falls on unpaid caregivers, usually family members or f...
K23 Resubmission - Impact of adoptive T cell therapy on immunity to SARS-CoV-2 after bone marrow transplant
The overarching goal of this proposal is the development of the candidate into an independent investigator in the field of immune modulatory cell therapy for critically ill childre...
Understanding the chromatin architectural landscape of retinal development at the single-cell level
Project Abstract: The 3D organization of the genome is important in controlling neuronal cell lineage commitment. As an extension of the CNS, the retina is an excellent model for s...
Molecular insights into the regulation of mitochondrial calcium uptake
Project Summary/Abstract Heart failure is the leading cause of death in the United States and represents a major burden on the US healthcare system. Mitochondrial dysfunction and d...
The opposing effects of matrix aging and muscle activity on extracellular vesicle promotion of muscle regeneration
ABSTRACT Young skeletal muscle displays remarkable resilience following an acute injury event, evidenced by a robust regenerative response and functional recovery. In contrast, eve...
A Cross-scale analysis of cell-ECM adhesion in early spinal column development
The tailbud is the posterior growth zone of the post-gastrulation vertebrate embryo containing the neural and mesodermal progenitors of the spinal column. The posterior neural tube...
Chemical biology tools for illuminating cannabinoid signaling pathways in opioid use disorder.
Project Summary/Abstract The opioid epidemic is a persistent public health crisis in the United States and abroad, historically dominated by the misuse of prescription opioids and...
Multiplex meningeal lymphatic activation for Alzheimer’s disease
PROJECT SUMMARY/ABSTRACT There is an unmet medical need to develop new therapeutic strategies for Alzheimer’s disease (AD). Brain lymphatic vasculature is (re)discovered at the int...
The MIGHT Trial - An Exploratory Clinical Trial of IVIG in anti-HMGCR ImmuneMediated Necrotizing Myopathy
PROJECT SUMMARY Anti-3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) immune mediated necrotizing myopathy (IMNM) is an increasingly recognized, severe subset of autoimmune myopath...
Small molecule inhibitors of CAPON-induced tau aggregation
PROJECT SUMMARY/ABSTRACT: Alzheimer's disease (AD), the most common type of dementia worldwide, is a rapidly increasing public health concern. There is an urgent need for the...
Choline-Related Polymorphisms in Fetal Alcohol Spectrum Disorders
Prenatal Alcohol Exposure (PAE) is a leading cause of cognitive disabilities known as Fetal Alcohol Spectrum Disorders (FASD). Interventions that ameliorate PAE’s impact are a high...
Image-based algorithms for remote cesarean surgical site infection diagnoses in diverse populations
Project Summary/Abstract Post-cesarean surgical site infections (SSIs) contribute to maternal morbidity and mortality globally; as rates of cesarean delivery increase, so will the...
Alleviation of chemotherapy-induced cardiovascular toxicity
ABSTRACT Many cancer drugs increase cardiovascular (CV) events, including hypertension, thrombosis, and cardiomyopathy. Damaged endothelial cells (ECs) caused by chemotherapy can t...
Modeling fetal lung development in congenital diaphragmatic hernia
PROJECT SUMMARY/ABSTRACT Congenital diaphragmatic hernia (CDH) is polygenic condition in which the fetal intestines and liver herniate into the thoracic cavity, resulting in lung c...
Smartphone Machine Learning Speech Enhancement System for Hearing Aid Devices for the Underserved and Rural Populations
Abstract This proposal responds directly to the purpose of the RFA-MD-23-003 SBIR Funding Opportunity Announcement (FOA). Nearly 44 million Americans experience hearing loss, but a...
Hormone-Free Prebiotic Muco-Adhesive Gels To Treat Vaginal Atrophy in Post-Menopausal Women
PROJECT ABSTRACT/SUMMARY Vaginal Atrophy (VA), a component of Genitourinary Syndrome of Menopause, is a chronic and progressive condition that affects approximately 50% of post-men...