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Examining Potential Mobile Measures of Strain, or the Accumulated Effects of Exposure to Demands
PROJECT SUMMARY/ABSTRACT The proposed K01 application will strongly support Dr. Raymond Hernandez's long-term career goal of developing tools usable in interventions to promot...
Romantic Relationships, Discrimination Stressors, and Alcohol Use among Sexual and Gender Minority Adults
Project summary Sexual and gender minority (SGM) adults disproportionately experience the burden of alcohol use. Compared to cisgender straight individuals, SGM adults are more lik...
Metabolic regulation of oxidative phosphorylation in pediatric AML relapse
PROJECT SUMMARY The overall goal of this research is to determine how lipid metabolism supports oxidative phosphorylation (OXPHOS) in acute myeloid leukemia (AML) stem cells. Leuke...
Role of epigenetic changes in intracellular survival and replication of Legionell pneumophila
1 Legionella pneumophila is an opportunist pathogen that infects an immune-compromised host and causes 2 inflammatory pneumonia in the lungs termed as legionnaire’s disease. L. pne...
Paradoxical role of anti-VEGF therapy in subretinal fibrosis of wet AMD
Project Summary Neovascular age-related macular degeneration (nAMD) with choroidal neovascularization (CNV) is a leading cause of vision loss in elderly Americans and is currently...
Leveraging protein-engineered biomaterials and bioorthogonal chemistries to elucidate the role of non-elastic matrix properties in regulating cell fate
PROJECT SUMMARY Cells are exquisitely sensitive to the mechanical properties of their environment, altering fundamental processes like adhesion, migration, cell division, and cell...
Diabetes Prediction During Pregnancy and In Utero Using Pancreas MRI
PROJECT SUMMARY The pancreas is smaller in individuals with diabetes and individuals at increased risk for developing diabetes, suggesting that small pancreas size may convey risk...
Reveal myeloid cell-mediated targeting through nano-bio interface
Reveal myeloid cell-mediated targeting through nano-bio interface. Project Summary/Abstract Nanomedicine based on ultra-small nanoparticles (usNPs), such as dendrimers, gold NPs, q...
Leveraging Quantitative Imaging from Lung Cancer Screening to Create Tools to Confront COPD
ABSTRACT A fundamental gap exists in our ability to screen for Chronic Obstructive Pulmonary Disease (COPD) that has resulted in widespread delayed diagnosis and underdiagnosis. CO...
Seminal plasma metabolomic signatures, preconception phthalates and reproductive outcomes.
SUMMARY Infertility is one of the most common reproductive health disorders affecting 16% of couples in the U.S. Infertility has been historically treated as a female problem; howe...
Mechanisms and functions of three-dimensional chromatin structures in quiescent cells
Project Summary Though the three-dimensional (3D) organization of chromatin regulates all DNA-dependent processes, determining chromatin mechanisms and functions in cells is challe...
Glycosaminoglycan-enabled technologies to reprogram chronic inflammatory states
PROJECT SUMMARY The severity of traumatic injuries has increased in recent years, resulting in further complications that can impair patient recovery or even result in death. The r...
Targeting CD14: A Novel Therapeutic Approach for Acute Respiratory Distress Syndrome
PROJECT SUMMARY/ ABSTRACT: Acute respiratory distress syndrome (ARDS) is associated with a 28-day mortality as high as 30-40%. However, there are no effective pharmacologic interve...
Modulating T Cell Activation to Combat HIV Persistence
PROJECT SUMMARY Major barriers to HIV cure include functional impairment of virus-specific CD8+ T cells and evasion of immune detection by a reservoir of latently infected CD4+ T c...
Understanding the relationship between cortical hyperexcitability and the progression of FTD/ALS pathology and behavioral deficits in mice
Frontotemporal dementia (FTD) is a progressive neurodegenerative disorder that causes severe personality and behavior changes. A hexanucleotide repeat expansion in the C9orf72 gene...
Integration of common, rare, and structural variation to define the genetic architecture of neuropsychiatric disorders
Abstract Neuropsychiatric disorders (NPDs), including autism spectrum disorder (ASD), epilepsy, and schizophrenia, are collectively common conditions in the human population. Many...
Atmospheric transformation of harmful cyanobacterial algae and novel mechanisms of pulmonary toxicity
PROJECT SUMMARY HABs occur when colonies of algae grow out of control and negatively impact ecosystems. These blooms can produce toxins that can have detrimental effects on animals...
Metabolic response to contraction in a 3D engineered muscle tissue model of aging
Title: Metabolic response to contraction in a 3D engineered muscle tissue model of aging Decreased skeletal muscle mass, specific force, increased overall fatty infiltration in the...
Multi-omic investigation of the adiposity-lipid intersection and its role in cardiovascular disease risk
ABSTRACT Excess body fat, referred to as “adiposity”, is a major contributor to heart disease, the leading cause of death worldwide. Anti-obesity medications (AOMs) designed to red...
Leveraging health systems' data to address oral health disparities
Project Summary/Abstract Poor oral health is a national symbol of social inequity, disproportionately affecting vulnerable populations. Despite its profound impact on overall well-...