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The evolution and genetics of recombination rate variation
PROJECT SUMMARY Meiotic recombination is a fundamental aspect of reproduction in most eukaryotes. Recombination rate, i.e. the number of crossovers per generation, is also a key mo...
Hippocampal and Genetic Mechanisms Underlying Development of Depression in Children at High Family Risk
PROJECT SUMMARY Why do some children at high risk for depression develop a disorder, while others remain psychopathology- free? My ultimate goal is to elucidate the neurobiological...
Endoplasmic Reticulum Stress Controls Innate Lymphoid Cells in Intestinal Inflammation
PROJECT SUMMARY/ABSTRACT This application proposes a five-year research career development program focused on innate lymphoid cells in the pathogenesis and individualized managemen...
Non-alcoholic beverages: A foundational assessment of their potential utility in reducing alcohol use
Abstract. Non-alcoholic beverages that seek to mimic alcohol (e.g., non-alcoholic beers, non-alcoholic wines, non-alcoholic liquor, and “mocktails”) are rapidly expanding in popula...
Rapid, Motion-Robust, and Low-Gadolinium MRI for Pediatric Brain Tumors
PROJECT ABSTRACT MRI is the gold standard for diagnosis, staging, and assessment of treatment response in pediatric brain tumors. Neuro-oncology MRI protocols often take more than...
Characterizing the sex-specific genetic architecture of alcohol use disorders with comorbid major depressive disorder
PROJECT SUMMARY/ABSTRACT Lifetime Alcohol Use Disorder (AUD) has an estimated US lifetime prevalence of 29.1%. Major Depressive Disorder (MDD) is often comorbid with AUD, with an e...
Investigating the Role of Heme-Induced Complement Activation in SCD Pregnancy
Project Summary/Abstract Though pregnancy in all cases harbors risk of complications, pregnancy in sickle cell disease (SCD) is associated with an exceptionally high risk of compli...
Beyond insulin: Next-generation modulators of insulin receptor for glycemic control
This research project is dedicated to the development and optimization of non-peptide ligands designed to activate insulin receptors, fundamentally transforming approaches to glyce...
MOBILIZE: Mobility & Transportation Solutions to Improve Hemodialysis Access
PROJECT SUMMARY 5.8 million individuals miss or delay medical care because of a lack of transportation. Persons with end stage kidney disease (ESKD) particularly depend on reliable...
Role of the gut barrier in inflammatory arthritis
PROJECT SUMMARY Antibiotic use is linked to increased risk for the onset or relapse of inflammatory arthritis, including rheumatoid arthritis and juvenile idiopathic arthritis, but...
The function and evolution of female-expressed seminal fluid proteins
PROJECT SUMMARY In all animals with internal fertilization, hundreds of seminal fluid proteins (SFPs) are transferred to females during mating. These SFPs have canonically been pri...
Strategies to Improve the Cardiovascular Health of Rural Working-Age Adults in the United States
PROJECT SUMMARY/ABSTRACT In the US, working-age adults (age 20 to 64-years) in rural areas experience significantly higher cardiovascular (CV) mortality rates than their urban coun...
Vestibular implant tested in patients with peripheral vestibular damage: effects on spatial orientation, navigation, and neuropsychologic function
This project will test the capability of a vestibular implant (VI) to improve cognitive dysfunction in patients with severe vestibular damage. We will measure how higher-level beha...
Mechanistic Study of PEG-asparaginase-Induced Liver Injury
Project Summary PEGylated asparaginase (PEG-ASNase) is one of the main drugs used for the treatment of pediatric acute lymphoblastic leukemia (ALL). Although PEG-ASNase is safe and...
Investigating the molecular regulation of cell protrusion function in 3D
PROJECT SUMMARY Cells shape and reshape themselves as they accomplish diverse functions in vivo. These cell shape changes result from physical and chemical feedback loops at multip...
Functional and molecular characterization of Oncofetal Stem Cells in CRC
Functional and molecular characterization of Oncofetal Stem Cells in CRC Project Summary. Background. Colorectal cancer (CRC) is the second most deadly cancer worldwide, with nearl...
Multidimensional analysis of the regulatory T cell response in children with severe viral pneumonia
Abstract Respiratory viruses are ubiquitous pathogens that cause a spectrum of clinical diseases ranging from asymptomatic carriage to severe pneumonia. Healthy children are much m...
Microglial Polarization: Brain Injury or Protection in Response to Intrauterine Infection
PROJECT SUMMARY Neurodevelopmental impairment remains the most vexing issue facing the clinical management of premature infants. Intrauterine infection and inflammation are signifi...
Augmented Reality to Guide Head and Neck Cancer Surgery
PROJECT SUMMARY For head and neck cancer patients, a positive surgical margin results in treatment intensification, increased cost, and an increased risk of recurrence and death. P...
A low cost approach for imaging calcium signals from a large population of neurons
Project Summary Optical recording of calcium transients from large number of neurons is an indispensable technique for comprehending neuronal ensembles during brain processes. Whil...