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606,025 grants found
Showing 29,841 – 29,860 of 606,025 grants
Mosaic in Vivo Perturbation (MVP) for systematic assessment of gene function in the eye
Project Summary Genetic screens have been a mainstay of scientific research in animals for over a century contributing immensely to our understanding of molecular cell biology, ani...
Advancing Causal Inference in Integrative Omics Analysis
Project Summary Emerging and rapidly progressing technologies can now measure the molecular phenotypes of genes, transcripts, proteins, metabolites, and gut microbiota. These omics...
Glycemic and Weight Loss Effects of Semaglutide in Subjects After Spinal Cord Injury and Type 2 Diabetes
Patients with spinal cord injury (SCI) develop diabetes at an earlier age and at a much higher rate than able bodied individuals (AB). Those with SCI and T2D are at much higher ris...
Prodrug engineering for enhanced biodistribution and pharmacokinetics
Project Summary Small molecular drugs play a pivotal role in treating a wide range of diseases, such as cancer, infection, cardiovascular diseases, and various other ailments. Howe...
The Penn LungMAP 3 team: Defining chronic lung disease
PROJECT SUMMARY Lung diseases are one of the leading causes of morbidity and mortality worldwide. Chronic Obstructive Pulmonary Disease (COPD) and other Chronic Lung Diseases (CLDs...
A map of ribosomal RNA regulation in human hematopoiesis
Project Summary / Abstract The hematopoietic tree contains cells of varying sizes, functions, and proliferation kinetics, and each cell type has a tightly regulated number of ribos...
Cell-cell and cell-matrix interactions driving progressive fibrosis in interstitial lung diseases
Project Summary Interstitial lung diseases (ILD) are a large group of lung diseases that are characterized by chronic, progressive pulmonary fibrosis. We hypothesize that in all IL...
Quantifying phenotypic adaptation of biological systems in dynamic environments
PROJECT SUMMARY/ABSTRACT Despite recent experimental advances in high-dimensional time-course data generation and accompanying inferential statistical approaches, we still lack the...
Standardizing and Harmonizing Behavioral and Social Science Research Factors in Alzheimer's Disease through Ontology-Based Approaches
ABSTRACT Behavioral and social science research (BSSR) is instrumental in comprehending Alzheimer's Disease and related dementia (ADRD) and its far-reaching implications for i...
2/7 PsycheMERGE: Advancing Precision Psychiatry
PROJECT SUMMARY Psychiatric disorders remain a leading cause of disability in the US and are associated with increased morbidity and mortality. Early detection and treatment is ess...
The BLAAST Trial: Bangladesh Lung Auscultation AI for Antibiotic Stewardship Randomized Controlled Trial
PROJECT SUMMARY: This is a submission for a National Institutes of Health R01 award called The BLAAST Project, which aims to conduct a randomized, double-blinded, placebo, non-infe...
Exploring the complex interactions between gut microbes and mucus
Project Abstract: The human gastrointestinal tract houses a diverse community of commensal gut bacteria that actively participate in maintaining host health. Among the intricate an...
Transcription Factor Network-Mediated Modulation of Transitional Senescence States
Abstract. The maintenance of a differentiated cell type (i.e., cell identity), a feature established by cell type- specific transcriptional programs, is critical for cell function...
Comprehensive study of Low Surface Brightness Galaxy Formation and Evolution
Galaxies are observed to come in many sizes and luminosities. Of particular interest are galaxies that, for their mass, are large and dim, called Low Surface Brightness (LSB) galax...
Research Initiation Award: Impacts of warming on the Atlantic bay scallop - from proteins to populations
Non-Technical Abstract: The Atlantic bay scallop is an important coastal species of economic and cultural significance that has declined by approximately 90% over the past few deca...
OP: Enhancing detectivity of avalanche photodiodes by engineering correlated noise
A nontechnical description of the project:Avalanche Photodiodes (APDs) are widely used for optical communications, environmental monitoring, imaging, and night vision. They operate...
Assembly of Novel Branched Ionic Polymers: Chirality Induction and 2D Heterostructures
NON-TECHNICAL SUMMARYIonic polymers (materials made of long molecular chains with ion-containing groups) possess unique internal morphologies guided by intermolecular and interfaci...
ERI: Improving Micromechanical Timekeeping Performance with Variable Mechanical Strain
This Engineering Research Initiation (ERI) award supports research that enables the characterization of the dynamics of micro-electro-mechanical resonators, thereby promoting publi...
Collaborative Research: Mechanics of Elastomers Tailored by Cation-Pi Interactions
Soft materials underpin important technologies such as adhesives, coatings, drug delivery, and energy storage. One key challenge with such materials is how they change when exposed...
CAS: Developing Data-Driven, Automated Methodology to Understand and Control Light-Driven Catalytic Processes
With the support of the Chemical Catalysis program in the Division of Chemistry, Professor Stefan Bernhard of Carnegie Mellon University will study catalytic processes that are dri...