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606,025 grants found
Showing 27,921 – 27,940 of 606,025 grants
Leveraging community-to-facility service provision to implement the World Health Organization HEARTS-D guidelines in Bangladesh for improving diabetes control and prevention.
PROJECT SUMMARY Type-2 diabetes (T2D) is rising at an alarming rate in most of low- and middle-income countries (LMIC). This rapid increase in the T2D burden has a particular impac...
Protein sequence influence on single-molecule transport dynamics
ATP-Binding Cassette (ABC) Transporters are paradigmatic molecular machines that use ATP binding and hydrolysis to power transmembrane transport of diverse substrates. Knowledge of...
Impact of Ethnicity on the Utility of Plasma Amyloid and Tau to Predict Alzheimer's Disease
ABSTRACT The development of biomarkers for Alzheimer’s disease resulted in the use of positron emission tomography (PET) and biofluid assays to detect AD pathology before clinical...
Basal Forebrain Non-cholinergic Circuit Mechanisms of Sustained Attention
ABSTRACT The long-term goal is to understand how basal forebrain (BF) circuits underlie cognitive functions like sustained attention. Traditionally, BF was thought to mediate atten...
Assessing the efficacy of a ROR1:PD-L1:CD2 multispecific T cell engager in ROR1-positive and -negative neuroblastoma models
PROJECT SUMMARY/ABSTRACT Few children with recurrent neuroblastoma survive. New therapies, particularly immunotherapies, are badly needed. Some promising results have recently been...
Adapting and testing a smoking cessation intervention for transgender and gender-diverse individuals
Despite the substantial decrease in the prevalence of smoking over the past 50-years, there are persistent and significant disparities in tobacco use among transgender and gender d...
1/2 Empagliflozin to Improve Right Ventricular Function in Pulmonary Arterial Hypertension
Project Summary/Abstract Despite advances in medical therapy for pulmonary arterial hypertension (PAH), mortality rates are still unacceptably high. This may be partly due to the l...
A Virtual, Group-Based, Expressive Writing Intervention for Survivors of Adolescent and Young Adult Cancer
PROJECT SUMMARY/ABSTRACT Adolescent and young adult cancer survivors (AYACSs) face multiple disparities, including impaired psychosocial health, isolation, limited access to psycho...
Delineating the neural computational network for object recognition
Project Summary/Abstract A core function of the human brain is object recognition, which underlies many higher-order functions like memory and emotion. Deficits in recognizing obje...
ApolipoproteinL1 Genotypes and Biomarkers of Immune Activation and Tubular Injury
PROJECT SUMMARY Chronic Kidney Disease (CKD) can effectively be a death sentence in sub-Saharan Africa where
Leveraging 30 years of Alzheimer's disease clinical trials data to decipher phenotypic response to treatment
PROJECT SUMMARY Looking back to move forward: The overall goal of this proposal is to examine the role of specific phenotypes, or subgroups of people based on a given characteristi...
Expanding Inclusion of All Subjects for Ultra-High Density Wearable fNIRS in the Everyday World
Abstract There is a great need to enable scientists to link brain activity to human movement, perception and cognition, and social communication and interaction continuously, in re...
Decoding the Brain-Liver Axis: Uncovering mechanisms of host defense
This research proposal seeks to uncover neuronal mechanisms orchestrating metabolic adaptations to bacterial infections, specifically delineating the pivotal role of the brain-live...
Age-Related Clonal Hematopoiesis of Indeterminate Potential (CHIP) in Exercise Responsiveness
Despite advances in diagnostic and therapeutic paradigms, cardiovascular disease (CVD) remains a primary cause of death across the world. Traditional risk factors for CVD are prima...
Piloting an Implementation Strategy for Mainstream Genetic Testing in Colorectal Cancer
PROJECT SUMMARY Of the 150,000 individuals diagnosed with colorectal cancer (CRC) each year, 15% will carry a hereditary pathogenic germline variant (PGV) including some associated...
Multi-modal sensory feedback mechanisms of fine and gross motor control in autism spectrum disorders
PROJECT SUMMARY The PI’s long-term goal is to become an independent researcher characterizing neurodevelopmental and phys- iologic mechanisms of sensorimotor integration in autism...
Modulatory effects of a retinoid-related protein on intestinal endocrine cells
PROJECT SUMMARY The gastrointestinal tract is the largest endocrine organ in the human body. This is due to the presence of intestinal endocrine cells, a scarce yet important cell...
Community Mitigation Against Xylazine
PROJECT SUMMARY/ABSTRACT We propose to use the Behavioral Model for Vulnerable Populations as a framework to examine the feasibility and acceptability of a community-based drug che...
Rest/Active Phase Specificity of APOE4 and Inflammation on Respiratory Plasticity
PROJECT SUMMARY This K99/R00 Pathway to Independence Award is designed so that the candidate will achieve her long-term goal of establishing an independent research career focused...
Master - 2/2 Empaglifozin To Improve Right Ventricular Function in Pulmonary Arterial Hypertension
DCC Project Summary Abstract Despite advances in medical therapy for pulmonary arterial hypertension (PAH), mortality rates remain high. Empagliflozin to Improve Right Ventricular...