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606,025 grants found
Showing 27,941 – 27,960 of 606,025 grants
Expanding CMV peptide vaccine with novel combinations and pathologies
Project Abstract Pediatric high-grade glioma (pHGG), diffuse midline glioma (DMG), recurrent medulloblastoma (MB), and recurrent ependymoma are devastating diseases. The median ove...
Non-genotoxic HSCT for ATM
Project Summary Ataxia telangiectasia (A-T) is a genetic disorder resulting from mutations in the ATM protein, essential for DNA repair and maintaining genomic integrity. Patients...
Control of adipose immune-stromal niche topography in obesity
PROJECT SUMMARY Obesity affects nearly half of the adult US population and is a risk factor for adverse cardiovascular events such as stroke and cardiac arrest, and Type II diabete...
Characterizing autonomic impairments in Frontotemporal Dementia
PROJECT SUMMARY/ABSTRACT Socioemotional impairments are core features of behavioral variant of Frontotemporal Dementia (bvFTD) and account for the majority of disease related morbi...
Uncovering the Molecular Determinants of Cell Type-Specific Connectivity
Project Summary/Abstract The numerous functions of the brain are carried out by circuits that are very precisely wired. Within a brain region, there can be hundreds of distinct cel...
Abandoned Settlements, Abandoned Health
Project Summary Up to 3 billion people will reside outside of the human climate niche due to climate change by the end of the century and the wholesale abandonment of communities a...
Resolution of nonalcoholic fatty liver and nonalcoholic steatohepatitis by a novel adipokine
Project Summary Nonalcoholic steatohepatitis (NASH) is initiated by lipid accumulation in hepatocytes and further characterized by lobular inflammation, hepatocyte ballooning, and...
Uncovering the Mechanisms of Amylopectinosis in LUBAC Deficiency
PI: Mitra, Sharmistha Glycogen is the largest soluble macromolecule in the cell and serves as a critical energy store in tissues. Co- ordinated actions by multiple enzymes control...
Extended amygdala somatostatin role in post-traumatic stress and alcohol use disorder
PROJECT SUMMARY/ABSTRACT Post-traumatic stress and alcohol use disorder (PTSD/AUD) are frequently comorbid and are a major US health burden. Individuals with comorbid PTSD/AUD mani...
Parvalbumin Interneuron Regulation of a Prelimbic to Ventrolateral Periaqueductal Gray Pathway for Modulating Pain Following Adolescent Intermittent Ethanol Exposure
PROJECT SUMMARY Adolescent alcohol misuse is a significant risk factor for alcohol use disorder in adulthood. Particularly concerning are the long-term effects on brain maturation...
Optimization and development of extracellular matrix-targeting probes for PET-based assessment of lung fibrosis disease activity
Idiopathic pulmonary fibrosis (IPF) is a rapidly progressing disease characterized by relentless extracellular matrix (ECM) deposition and lung stiffening that leads to death 3-4-y...
Emotional and biobehavioral mechanisms of parent-infant emotional synchrony
Project Summary/Abstract My career goal is to lead a transdisciplinary research team that investigates multi-level mechanisms leading to optimal child socioemotional development fr...
Preventing Cervical Cancer through HPV Self-collection and Patient Navigation among Women Living with Chronic Conditions and Social Vulnerability
PROJECT SUMMARY/ABSTRACT Despite advances across the cervical cancer care continuum – screening, treatment, and survivorship care, women with social vulnerability (i.e. poverty, ru...
The Impact of Anesthetics on Lymphatic Vessel Contractility and Extracellular Fluid Uptake
Project Summary / Abstract The lymphatic system, integral to fluid balance, fat absorption, and immunity, actively propels lymph fluid via specialized lymphatic muscle cells (LMCs)...
Exploring immune-mediated stem cell heterogeneity within and across niches
PROJECT SUMMARY The skin represents the first and outermost body’s line of defense, continuously dealing with potentially harmful environmental and physical stressors. To protect i...
Using Single-cell and Spatial Multi-omics to Improve Adoptive Cell Therapy against Pancreatic Cancer
Project Summary/Abstract Adoptive T cell therapy (ACT) has been effective against certain blood cancers but has had limited success against solid tumors, such as pancreatic cancers...
Feasibility of Tele-Singing at Home for Older Adults with Mild Cognitive Decline
ABSTRACT An estimated 6 million adults aged 60 and over in the United States have Alzheimer’s disease and related dementias (AD/ADRD) at a cost of $345 billion per year. Older adul...
Unravel the Epigenetic Mechanisms of Cellular Rejuvenation and Identify Universal Rejuvenating Transcription Factors
PROJECT SUMMARY Aging is a complex process characterized by many hallmarks, such as DNA instability, epigenetic changes, and loss of protein homeostasis. Cellular rejuvenation, whi...
Achieving Independence and Mastery in Schools – An RCT for Middle-Schoolers with Autism
Project Summary/Abstract Children with Autism Spectrum Disorders (ASD) present with numerous deficits in organization, planning, prioritizing, memory, and materials management (OPM...
Gene Therapy for Xeroderma Pigmentosum - Cockayne Syndrome.
PROJECT SUMMARY The goal of this project is to refine our gene therapy strategy for Xeroderma Pigmentosum-Cockayne Syndrome (XP-CS), with the ultimate aim of improving the neurolog...