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606,025 grants found
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Project 2: Integrating race, ethnicity, and genomic ancestry across GENIE to understand genetic and environmental contributions to pan-cancer risk, prognosis, and outcomes
PROJECT 2 ABSTRACT Integrating race, ethnicity, and genomic ancestry across GENIE to understand genetic and environmental contributions to pan-cancer risk, prognosis, and outcomes....
Project 3: Predictors of sensitivity to immunotherapy and targeted treatments based on real world evidence
PROJECT 3 ABSTRACT Predictors of sensitivity to immunotherapy and targeted treatments based on real world evidence Project Leaders: Phillipe Bedard (Princess Margaret); Nikolaus Sc...
Administrative Core
CORE C ABSTRACT Administrative Core Core Leader: Charles Sawyers (MSK) The P01 Administrative Core will provide the organizational support and leadership necessary to support the s...
Hedgehog signal transduction: mechanism of Ci/Gli transcriptional effector activation
Project Summary This project aims to understand the basic molecular mechanisms of Hedgehog (Hh) signal transduction in Drosophila. Hh proteins are prominent members of the limited...
PET Biomarker for synaptic density changes after radiation therapy
Project Summary/Abstract: Whole brain synaptic density imaging with quantitative positron emission tomography (PET) has demonstrated critical insights into understanding of neurode...
Revolutionizing Pediatric Tonsillectomy Pharmacology and Therapeutics
PROJECT SUMMARY/ABSTRACT Safe and effective analgesia after surgery is a paramount yet unmet medical need in children, and poorly treated pediatric pain remains a persistent and si...
A large scale investigation of the vaginal ecosystem in preeclampsia
ABSTRACT Preeclampsia is a pregnancy complication characterized by high blood pressure and signs of systemic organ damage, often the liver and kidneys. It poses significant clinica...
Sexual orientation-related disparities in unintended pregnancies by state-level policy and structural contexts
PROJECT SUMMARY/ABSTRACT Sexual minority women (SMW; e.g., those with same-sex partners or attractions, or identify as lesbian, gay, or bisexual) are subjected to stigma and discri...
Improving End-of-Life Care for Hospitalized Patients with Lewy Body Disorders
PROJECT SUMMARY Lewy body disorders, a subset of Alzheimer’s disease and related disorders (ADRDs), are the second most common neurodegenerative disorders worldwide and the 14th le...
Multifunctional EPRI Instrument to Advance Therapies in Biomedical Sciences
Abstract: Electron paramagnetic resonance imaging (EPRI), where electron spins are the subject of the investigation, is a promising tool and has the ability to provide maps of mult...
Automated, in-line hexavalent chromium analyzer
Project Summary/Abstract The proposed Phase II SBIR Project will convert our successful feasibility study into a prototype system for in-line, autonomous monitoring of hexavalent c...
Primary Immune Deficiency Treatment Consortium (PIDTC): A resource to drive scientific and clinical advances related to the treatment of inborn errors of immunity
Project Summary/Abstract The Primary Immune Deficiency Treatment Consortium (PIDTC) was founded in 2009 to bring together immunologists, bone marrow transplant (BMT) physicians, an...
Mathematical Models for Obesity-Induced Type 2 Diabetes Mellitus and Chronic Wound Healing
Project Summary Aim: To develop a predictive mathematical model of obesity-induced diabetes and chronic wound that includes a realistic representation of the main physiological fac...
Role of cortical GABAergic interneurons in psychedelic drug action
PROJECT SUMMARY Psychedelics are increasingly studied as a potential treatment for mental illnesses. For example, recent clinical trials showed positive outcomes after psilocybin-a...
Development of a Tailored Alcohol Screening, Brief Intervention, and Referral to Treatment Protocol for Older Adults with Chronic Pain
PROJECT SUMMARY/ABSTRACT Hazardous alcohol use is highly prevalent among the millions of older adults who have chronic pain. This is alarming, given that hazardous drinking can exa...
Environmental and social determinants of mammographic features
Percent mammographic density (PMD) is one of the strongest risk factors for, and is considered an intermediate marker of, breast cancer. Recent wide spread uptake of digital mammog...
Heat Therapy for the treatment of post-acute COVID-19 syndrome
Post-acute sequelae of SARS-CoV-2 infection (PASC) affects 5 out of 10 patients hospitalized for the coronavirus disease 2019 (COVID-19) and ~11% of all adults infected by SARS-CoV...
Sexually Dimorphic Vasopressin Circuits in the Control of Social Interest
Project Summary Disorders of social behavior are increasingly prevalent and pose a substantial burden to society. These disorders often show sex differences in prevalence, expressi...
Increasing Diversity of the Genomics Workforce Through Accessible Data and Visualization
Project Summary Despite efforts to increase diversity and inclusion, opportunities in genomics education and research are still unequally offered to people with disabilities. While m...
A Randomized Controlled Trial of A Smartphone Delivered Treatment for Suicidal Thoughts and Behavior
Modified Project Summary/Abstract Section Suicidal thoughts and behavior (STB) claim nearly 50,000 Americans and contribute >$90 billion in disease burden annually. Existing STB...