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606,025 grants found
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Functional characterization of cell surface RNA biology
PROJECT SUMMARY / ABSTRACT The composition and organization of the cell surface are critically important for cell-to-cell communication and for the ability of cells to interact wit...
No REST for 5-HT Neurons Following Traumatic Brain Injury
PROJECT SUMMARY/ABSTRACT Traumatic brain injury (TBI), including closed-head injury (CHI), is a leading cause of disability in the United States. Chronic neuropsychiatric comorbidi...
Supporting the implementation of prevention strategies by public health nurses to reduce intimate partner violence in Alaska
PROJECT SUMMARY/ABSTRACT Intimate partner violence (IPV) is a critical social determinant of health, affecting over 40% of women and men in the US. IPV is particularly prevalent in...
Validation and Kinetic Characterization of Blood-Cerebrospinal Fluid Barrier-Traversing Proteins in Aging With Library-Free Multiplexed Targeted Proteomics
PROJECT SUMMARY/ABSTRACT The choroid plexus (CP) is a critical component of the blood-brain barrier (BBB), whose function is known to degrade with aging. A better understanding of...
Adaptation and Testing of an Evidence-Based Sexual Health Communication Skills Training Intervention for Patients with Prostate Cancer
Prostate cancer (PCa) is the most common non-cutaneous cancer in U.S. men and causes sexual dysfunction in up to 90% of patients. Sexual dysfunction is associated with long-term re...
Intergenerational Adversity Exposure and Language Acquisition
PROJECT SUMMARY/ABSTRACT Approximately 65% of the United States population reports at least one adverse childhood event. A third of adversity-exposed youth do not meet age expectat...
Alternative Stimulation Mode and Location for Auditory Hallucination Neuromodulation Treatment
Project summary: Current efforts to use rTMS to treat auditory hallucinations refractory to available antipsychotic medications show promising efficacy but replicability of the eff...
Developing measures to improve access to integrated mental health care services in under-resourced global settings
PROJECT SUMMARY / ABSTRACT Background: Mental disorders are the leading cause of morbidity and mortality worldwide. Despite this immense burden, there are significant mental health...
NeuroVu: A Novel Cloud-based Microscope for Remote Neurosurveillance of the Seizure-Brain Tumor Nexus
ABSTRACTRecent clinical and preclinical studies have shown that seizures can adversely interact with brain tumors to sƟmulate tumorcell proliferaƟon and invasion. Moreover, posƟcta...
Hybrid Effectiveness-Implementation Trial of Massed PTSD Treatment in a Community Substance Use Program
Project Summary/Abstract Over 20 studies have shown that prolonged Exposure (PE) is a highly efficacious and effective treatment for posttraumatic stress disorder (PTSD). While PE...
Using causal aging biomarkers and protein design to develop novel anti-aging interventions
Project Summary In mammals, 5-methylcytosine is the most common form of DNA methylation, and the level of methylation of some specific CpG sites shows a strong correlation with age...
Integrative Multiomics and Clinical Laboratory Translation for Advanced, Rare, and Pediatric Cancers
ABSTRACT The project aims to incorporate emerging technologies in genomics, transcriptomics, epigenomics and proteomics for the analyses of advanced, rare, and pediatric cancers. T...
Epigenetic Drivers of Chronic Low Back Pain
PROJECT SUMMARY / ABSTRACT Chronic Low Back Pain (LBP) is a leading cause of disability worldwide and one of the most common reasons patients are prescribed opioids, despite their...
Quantitative in vivo dosimetry for radiotherapy using model-based X-ray-induced acoustic computed tomography
Abstract Accurate dose delivery at the tumor site is crucial for the success of radiotherapy (RT) for cancer treatment. However, as yet there are no techniques in clinics with the...
Use of kidney organoids to investigate developmental programs and the effects of fetal exposures
Abstract In utero exposures to insults such as pregestational diabetes can have significant repercussions for proper growth and development. Exposure to the diabetic milieu can lea...
Instructive roles of mesenchymal proteoglycans in hair follicle morphogenesis and maintenance
PROJECT SUMMARY Hair is produced in the hair follicles. Hair follicle formation, cycling, and neogenesis relies on extensive cross- talk between hair follicle keratinocytes and der...
Developing mountain-like biochips to enrich respiratory microdroplets
Respiratory microdroplets, commonly spread in crowded settings like schools or cafes, can transmit infections. Microfluidic devices, which process small fluid volumes, are increasi...
Extending the genetic understanding of Thrombotic Thrombocytopenic Purpura (TTP)
Thrombotic thrombocytopenic purpura (TTP) occurs due to a deficiency of an enzyme involved in blood clotting (ADAMTS13), and results in low platelets in the blood (thrombocytopenia...
Leveraging Observational (Real World) Data to Advance Precision Oncology
OVERALL ABSTRACT Leveraging Observational (Real World) Data to Advance Precision Oncology Principal Investigator: Charles Sawyers, Memorial Sloan Kettering Cancer Center Precision...
Project 1: Overcoming methodologic barriers to analysis of observational clinico-genomic data in oncology
PROJECT 1 ABSTRACT Overcoming methodologic barriers to analysis of observational clinico-genomic data in oncology Project Leaders: Kenneth Kehl (DFCI); Deborah Schrag (MSK) Precisi...