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606,025 grants found
Showing 26,901 – 26,920 of 606,025 grants
Cellular mechanisms of palatal shelf outgrowth
Project Summary/Abstract Craniofacial morphogenesis involves a multitude of cell behaviors, including mesenchymal cell movements that change the physical properties of tissues, cul...
The influence of the developing circadian system on neuroimmune function and neuropsychiatric behaviors
PROJECT SUMMARY Approximately 1 in 3 American adolescents have been diagnosed with an anxiety disorder; 3 in 20 with a mood disorder, with 1 in 3 female adolescents experiencing at...
Estimating acute impacts of unconventional oil and gas development on cause-specific hospitalization via satellite-based exposure assessment
Project summary Onshore expansion of Unconventional oil and gas development (UOGD) is considered an emerging environmental health issue due to its disproportional proliferation in...
Antibodies in the neurologic effects of COVID-19
Abstract: The neurological manifestations of SARS-CoV-2 infection, known as neuroCOVID-19, have raised concerns regarding the underlying mechanisms and potential involvement of ant...
Head and neck anthropomorphic phantoms for MRI methods development at low and high fields
Project Summary/Abstract 7T MRI systems are installed worldwide more and more rapidly and are currently being evaluated in clinics for a number of conditions such as detection of s...
Optical Phantoms Mimicking Microvascular Cerebral Blood Flow (Supplement)
PROJECT SUMMARY The primary goal of this administrative supplement project is to characterize, optimize and disseminate the optical phantoms mimicking microvascular cerebral blood...
Point of care diagnostic for sickle cell disease
Project Summary Sickle cell disease (SCD) is severe hematological disease seen in Sub-Saharan Africa and the U.S., affecting up to 3% of the newborn population Africa. In the US, t...
Risk Perception and Tolerance in Contraceptive Use
Project Summary Reducing the large percentage of undesired pregnancies in the United States (43%) is a top public health priority because control over pregnancy is crucial for wome...
Epigenetic regulation of the regenerating axolotl forelimb's proximodistal axis by retinoic acid
PROJECT SUMMARY The axolotl salamander is capable of perfect, scar-free regeneration throughout its body. In order to regenerate a complex biological structure such as a limb, cell...
Antigen-targeted activation of Topo1 inhibitors via click chemistry
Abstract Most drugs are administered systemically and spread throughout the body. Due to lack of specificity for the pathological site, high doses are required to achieve effective...
Using ecological momentary assessment to develop an adaptive psychological intervention for young adults with chronic pain.
PROJECT SUMMARY Chronic pain is a widespread concern, affecting 12% of young adults globally (ages 18-29). These individuals face significant burden, including the risk of chronic...
Reducing prostate cancer mortality in African American men by early disease detection using DNA fragmentation profiles and methylated DNA patterns of plasma derived cell free DNA
Project Summary/Abstract: African American (AA) individuals with prostate cancer (PCa) face significantly worse clinical outcome than their European American (EA) counterparts. The...
Remote, Young Adult Lay-Counselor Delivered Behavioral and Digital Intervention for Youth to Promote Vaping Cessation and Prevent Escalation of Tobacco Use
PROJECT SUMMARY/ABSTRACT While tobacco smoking has declined dramatically among adolescents and is now almost rare, the prevalence of electronic nicotine delivery device (ENDS, nico...
Machine Learning remedies to unmeasured confounding biases in environmental mixture studies
SUMMARY To draw causal interpretation and policy recommendations from epidemiological investigations of environmental mixtures, it is key to quantify the impact of residual unmeasu...
Cholinergic Mechanisms of Associative Learning in Cortical Circuits
Project Summary Numerous observations both in humans and in experimental animals support the notion that acetylcholine (ACh) is important for learning and memory. However, the cell...
Evaluation of a brief, scalable module to mitigate suicidal ideation among youth
Project Summary Suicidal ideation (SI) is prevalent and impairing in youth and can lead to restrictive and intensive care. There is a critical need to develop and test scalable bri...
Imaging of pain sources in myofascial pain syndrome
PROJECT SUMMARY Myofascial pain syndrome (MPS) is one of the most common forms of acute and chronic musculoskeletal pain, a common cause for opioid use, and affects 10-15% of patie...
Interrogating the role of arachidonic acid metabolism in modulating the tumor immune microenvironment as a novel path to therapeutic intervention
ABSTRACT Cancer has been characterized as a chronic, poorly healing wound where inflammatory and proliferative processes continue unchecked without normal healing and resolution of...
Developing AI-Driven Pain Intensity and Pain Sensitization Biomarker Signatures to Optimize Neonatal Pain Management
Newborns in the neonatal intensive care unit (NICU) often undergo invasive procedures or surgeries that cause prolonged pain.Cumulative pain exposures during early brain developmen...
Humanized mouse model of periodontitis
This application for R21 grant, entitled, “Humanized mouse model of periodontitis”, proposes to develop a humanized mouse model of periodontitis to study the possible pathogenic ro...