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606,025 grants found
Showing 26,881 – 26,900 of 606,025 grants
Brain Metabolites and Temperature Changes in Obstructive Sleep Apnea Adults
PROJECT SUMMARY/ ABSTRACT Obstructive sleep apnea (OSA), a life-threatening condition, affects ~10% adults in the United States. The condition is accompanied by multiple symptoms (...
Longitudinal Effects of E-cigarette Use on Cardiovascular and Pulmonary Health
PROJECT SUMMARY Electronic nicotine delivery systems (ENDS) are used by millions of Americans, however, we do not understand their long-term health effects. Although ENDS use deliv...
Decreased SRD5A2 and Alternative Estrogen Signaling in Prostatic Cell Survival
PROJECT SUMMARY Benign prostatic hyperplasia (BPH) remains a significant and incurable health problem that will become more prevalent as life expectancy increases. Despite the intr...
4/5-Clinical Outcome Prediction of Psychosis from EHRs (COPPER)
PROJECT SUMMARY Clinical predictors are now firmly incorporated into routine standard-of-care in many fields of medicine, in contrast with Psychiatry where quantitative predictors...
2/5 Clinical Outcome Prediction of Psychosis from Electronic Health Records (COPPER)
PROJECT SUMMARY Clinical predictors are now firmly incorporated into routine standard-of-care in many fields of medicine, in contrast with Psychiatry where quantitative predictors...
The Gut Microbial and Dietary Origins of Cancer Treatment-Related CognitiveImpairment
During chemotherapy, 34% of breast cancer survivors (BCS) experience cancer treatment-related cognitive impairment (CRCI). CRCI degrades memory and executive function as well as qu...
The California Abundant Birth Project Evaluation: Advancing Birth Equity through Guaranteed Income for Pregnant People
Project Summary/Abstract Pregnancy is a critical period of development: stress during pregnancy can lead to adverse birth and long-term health outcomes, as well as compromise infan...
Neurogenetic influences linking impulsive personality traits and alcohol use disorder progression across development
PROJECT SUMMARY/ABSTRACT Alcohol use disorder (AUD) is a prevalent global health problem with substantial social, economic, and public health costs. Progression from initial alcoho...
Engineered Viscoelastic Hydrogels for Optimized Generation and Transplantation of Human iPSC-Derived Salivary Gland Organoids to Treat Hyposalivation
PROJECT SUMMARY Human salivary gland organoid (SGO) are promising in vitro models for drug discovery, disease modeling, regenerative therapy. However, the vast majority of organoid...
Increasing Access to Hearing Healthcare: An Assessment of Pharmacy Technician Educational Training for the Provision of Over-the-Counter Hearing Aids in Rural Alabama and Mississippi Pharmacies
Project Summary/Abstract Hearing loss is a major public health concern due to its negative association with emotional well-being, cognition, and physical ailments, such as diabetes...
Contraceptive Autonomy: A Mixed-Methods Approach to Developing a Novel Family Planning Measure
Project Summary Contraceptive autonomy – people’s ability to decide for themselves what they want in regard to contraceptive use, and to realize that decision – is essential for re...
Sox4 Dependent Parietal Cell Plasticity in Gastric Ulcer
PROJECT SUMMARY/ABSTRACT Gastric ulcer is increasing in the United States due to increasing use of non-steroidal anti-inflammatory drugs (NSAIDs) and Helicobacter pylori infection....
Chemical Approaches to Modulate PAX3-FOXO1 in Fusion-Positive Alveolar Rhabdomyosarcoma
PROJECT SUMMARY/ABSTRACT Fusion-positive alveolar rhabdomyosarcoma (FP-RMS) remains a poorly understood but highly fatal cancer of childhood. The pathognomonic fusion oncoprotein o...
Flexible bioelectronics platform converging capillary-like delivery network and sensing feedback network for improving cardiac tissue engineering
Project Summary Cardiac diseases remain the leading cause of human morbidity and mortality. Cardiac microtissues/organoids built from human induced pluripotent stem cell–derived ca...
Integrating PrEP Decision-Making into Contraceptive Counseling in Family Planning Clinics
Problem: There is high unmet need for PrEP among cis-gender women in the U.S. Even where resources are available to support PrEP, it remains inaccessible to women because too few c...
A Multi-Level Integrated Strategy to Optimize PrEP Adherence for Black MSM and Accelerate Implementation at Scale
PROJECT SUMMARY Scalable interventions that facilitate adherence to HIV PrEP are urgently needed to address the alarming HIV incidence in Black MSM. In 2020, only 26% of Black MSM...
Measuring kidney NaCl transport in vivo with genetically encoded sensors
Abstract Nephron salt reabsorption is essential to salt and water homeostasis and its dysregulation is involved in the progression of kidney and cardiovascular diseases, including...
Nephrogenesis on a chip: an simple modular platform to spatially pattern extracellular matrix, stromal cells, and soluble factors
Abstract It is well appreciated that the spatial organization of the biophysical and biochemical cues in the extracellular matrix (ECM) in concert with the stromal cell organizatio...
Adolescents' Social Media Management Strategies: Bidirectional Links to Objective Social Media Use and Mental Health Outcomes
PROJECT SUMMARY The past decade has witnessed exponential surges in social media use among U.S. adolescents. Meanwhile, as mental health problems increase for all ages, the adverse...
Novel doula intervention to leverage clinic-community connections to support perinatal intimate partner violence survivors
ABSTRACT Intimate partner violence (IPV) during the perinatal period is a pervasive and devastating public health epidemic. IPV also intersects with structural and institutional vi...