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606,025 grants found
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Mechanisms of ciliopathy associated structural birth defects
PROJECT SUMMARY/ABSTRACT Cilia are complex structures with more than 1,300 proteins involved in their formation and function. During development, disruption of cilia function cause...
SUNBEAM Birth Cohort: Deciphering the role of early life skin dysfunction in development of the allergic march
PROJECT SUMMARY/ABSTRACT Allergic diseases, including atopic dermatitis (AD), food allergies (FA), and asthma are common in young children and are often co-morbid, suggesting a sha...
Maintenance and Enhancement of the Asian American enriched Cohort
ABSTRACT Over 90% of Asian American (AsA) adults are either first-generation (foreign-born) or second-generation immigrants, experiencing a substantial environmental and sociocultu...
Role of ERK1/2 signaling in SARS-CoV-2 -induced dysregulated immunity and lung pathology.
Project Summary (Abstract): Emerging and re-emerging respiratory viruses such as SARS-CoV, MERS-CoV, SARS-CoV-2, and avian and swine influenza viruses continue to pose a significan...
Developing Human Pluripotent Stem Cell Tools for Region-Specific Pain Circuits
PROJECT SUMMARY/ABSTRACT Species-specific differences and the complexity of cellular interactions involved in human pain perception have created challenges relying on conventional...
Genetic editing and cell therapy for correction of CLCN7 mutations in osteopetrosis
Project Summary: Osteopetrosis is a heritable skeletal disorder characterized by abnormal systemic increase in bone mass density, bone marrow failure, bone fractures, osteomyelitis...
Social Determinants of Adolescent and Young Adult Mortality: New Evidence from Large-Scale Administrative Data
Concerns about deteriorating mental health, substance use disorders, early development of chronic conditions, exposure to economic shocks, and to violence---causes that may all lea...
Investigation of blood fitness genes in the tsetse fly symbiont Sodalis glossinidius
Project summary/abstract: Tsetse flies (Genus: Glossina) are cyclic vectors of protozoan African trypanosomes (Trypanosoma sp.), the causative agents of human and animal African tr...
Pathways regulating profibrotic macrophages in a novel explant model of systemic sclerosis-associated interstitial lung disease
Systemic sclerosis (SSc) is a complex disease involving multiple cell types, leading to a plethora of clinical manifestations. SSc-associated interstitial lung disease (SSc-ILD) is...
Electrified cryo-EM: a new tool to capture metastable neuron structures during an action potential
Project Summary:There remains a critical blind spot in the study of biological systems. In situ imaging techniques like super-resolution microscopy can elucidate cellular dynamics...
Trust Fund of the Federal States of Micronesia
160000📋 Staff Comments1/1/2008 Loan applications and disbursements are still being received and processed as the projects continue to evolve. Ongoing monitoring and evaluation are...
Exploring cortical inhibitory circuit design in the human brain
PROJECT SUMMARY A basic understanding of human neural circuit design is essential to grasping neurological disease processes and developing targeted brain therapies. However, due t...
Late-stage development and de-risking of a novel monoclonal antibody immunotherapy for EGFR-positive solid cancers
Abstract The primary objective of this project is to develop therapeutic IgA to uniquely harness the tumor cytolytic potential of neutrophils to target EGFR-mutant non-small cell l...
ATUSA: World's First Wearable and Automated 3D Breast Ultrasound System with AI
PROJECT SUMMARY Breast cancer (BC) is a formidable global health challenge, affecting millions of women worldwide annually. This malignancy is a leading cause of death among women,...
Advancing Cancer Control Equity Research Through Transformative Solutions in Patient Navigation (ACCERT PN)
OVERALL – ABSTRACT Chicago, one of the most diverse yet segregated cities in the US, is characterized by egregious cancer health inequities. We propose to establish the Advancing C...
Administrative Core
ADMINISTRATIVE CORE – ABSTRACT To support the mission of the Advancing Cancer Control Equity Research Through Transformative Solutions in Patient Navigation (ACCERT PN) Center as a...
Research Methods, Measures, and Data Management Core
RESEARCH METHODS, MEASURES AND DATA MANAGEMENT CORE – ABSTRACT The Advancing Cancer Control Equity Research Through Transformative Solutions in Patient Navigation Center (ACCERT PN...
Advancing Innovations in Patient Navigation and Implementation Science to Address Structural Racism and Social Determinants of Health
SOCIAL DETERMINANTS OF HEALTH RESEARCH PROJECT – ABSTRACT Cancer is a leading cause of death in Chicago, and Black, Latinx and low-income Chinese communities in Chicago face signif...
Advancing Cancer Control Equity Research Through Transformative Solutions in Patient Navigation - Community Responsive Projects
COMMUNITY RESPONSIVE PROJECTS – ABSTRACT Community Responsive Projects within the Advancing Cancer Control Equity Research Through Transformative Solutions in Patient Navigation (A...
Neuroscience Diversity to Elevate Education and Research Development
Project Summary/Abstract: The number of Native Americans (NA) entering the Science Technology Engineering and Mathematics (STEM) workforce is the smallest proportion of any ethnici...