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606,025 grants found
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Peptide Nucleic Acid (PNA) Oligomers for Targeted Disruption of Biomolecular Condensates in ALS/FTD
PROJECT SUMMARY The formation of biomolecular condensates (BMCs) is an important phenomenon in biology, creating transient compartments that can accelerate biochemical reactions or...
Investigating Histone 3 Dopaminylation in Parkinson's Disease
Summary/Abstract Parkinson’s Disease (PD) is the second most common neurodegenerative disease affecting nearly one million people in the United States, and up to 80% of PD patients...
Defining the role of the mitochondrial protein, GOT2, in pancreatic cancer metastasis and epigenetic dysregulation
Project Summary Pancreatic adenocarcinoma (PDAC) is a highly aggressive and deadly form of pancreatic cancer with a poor prognosis and low survival rate. Despite advances in treatm...
TB PrEP - Integrating HIV prevention with TB household contact evaluation
ABSTRACT HIV and TB are leading and linked global epidemics. Household members of people with TB have an elevated prevalence and incidence of both TB and HIV. HIV pre-exposure prop...
Unraveling the role of molecular capacitors that obscure cryptic genetic variation in Astyanax mexicanus during the evolution of eye loss
PROJECT SUMMARY / ABSTRACT Personalized medicine and genetic counseling frequently run up against the problem of hidden variability. Low- penetrant phenotypes complicate prediction...
Defining Mechanisms Governing Myc Stability and its Modulation by Aurora Kinase A
Project Summary/Abstract. The Myc gene family encodes three highly conserved transcription factors (N-, c-, L-), known to be oncogenic drivers in many cancers. Dysregulation of Myc...
SCH: Smart Breath- based Diagnosis of Pulmonary Exacerbations in Children with Cystic Fibrosis through Machine Learning: Towards Noninvasive Health Monitoring in Real-Time
Cystic fibrosis (CF) is a genetic disorder that negatively affects young people across the globe. Pulmonary exacerbations (PEx), episodes of decreased lung function accompanied by...
Impact of Alcohol on Claustrum Function
Project Summary / Abstract While cognitive impairment is a key domain of alcohol use disorder, the neurocircuit mechanisms underlying this remain poorly understood. This project in...
HIV and Women's Health
PROJECT SUMMARY The program will strengthen patient-oriented HIV clinical investigation training of physician-scientists and other exceptional clinicians in Mwanza, in northwestern...
UNZA-Vanderbilt Training Partnership for HIV-NCD Research (UVP-2)
PROJECT ABSTRACT The goals of the parent project UNZA-Vanderbilt Training Partnership for HIV-NCD Research (UVP-2) are to build the University of Zambia (UNZA)’s research capacity...
Promoting diverse perspectives in research to optimize integration of NCDs and HIV care in Kenya
Abstract Turkana County located in Northwest Kenya is a semi-arid region that has traditionally been underserved and marginalized because of nomadic lifestyle of its people. The 20...
HIV Basic Science and Cure Research Training for Scientists at the University of Ghana (H-Cure-RT)
PROJECT SUMMARY This program is an extension of our successful HIV basic science training program with the HIV Cure Research Infrastructure Studies (H-CRIS) based at the University...
Fabrication of solid and long-lasting phantoms for calibrating parametric OCT imaging
Project Summary Optical coherence tomography (OCT) has revolutionized medical diagnostics by providing high- resolution morphological imaging. However, the early stages of many dis...
Refining and Expanding the SACERT-Learning Collaborative and Integrated Measures Bank-South Africa
Project Summary In response to PAR-18-901, we propose the Sustainable Academic Capacity Building for Excellence through Research and Training (SACERT) Program. Under the leadership...
Early podocyte injury in collagen IV nephropathy
for R-56 related to 1R01DK139111-0The goal of this project, “Early podocyte injury in collagen IV nephropathy”, is to understand the earliest events in podocyte injury in Collagen...
Long-term alteration of the airway epithelium after early life RSV infection
Severe RSV-bronchiolitis infection has been associated with the development of asthma later in childhood. RSV is the primary cause of bronchiolitis in children worldwide, and it is...
Structure and Biology of Tissue Factor Pathway Inhibitor-2
Project Summary Tissue factor pathway inhibitor-2 (TFPI-2) consists of three Kunitz domains arranged in tandem flanked by a short acidic amino terminus and a highly basic C-termina...
MITRE CORP:1105900 [24-002923]
This contract supports the All of Us Research Program (AoURP), a Precision Medicine initiative at the National Institutes of Health (NIH), an agency within the Department of Health...
Better use of evidence by institutions, to improve research culture, rigour and transparency
The aim of this project is to undertake a body of high quality research that can be used to directly improve the use of applied meta-research evidence in institutional decision-mak...
Defining viral and human determinants of Dengue virus susceptibility
Dengue virus (DNV) is the world leading mosquito-borne virus and a WHO- priority.With 390 million annual infections, climate change risks infections of naïve populations and spillo...