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Programming cellular behavior by mechanical forces
ABSTRACT Cellular behaviors are modulated by a variety of stimuli in the environment, which can be generally categorized as chemical, physical, and biological factors. Previous wor...
A novel approach for treating myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML)
Abstract Patients diagnosed with myelodysplastic syndrome (MDS) face a challenging treatment landscape, with limited options consisting mainly of blood transfusions and hypomethyla...
Role of hypernutrition and metabolic stress in non-alcoholic steatohepatitis (NASH) driven hepatocellular carcinoma (HCC)
PROJECT SUMMARY – OVERALL Hepatocellular carcinoma (HCC) is the most common primary liver cancer and a rising cause of cancer mortality. HCC related to metabolic stress is on the r...
Core A: Administrative Core
PROJECT SUMMARY – CORE A: ADMINISTRATIVE The Administrative Core A, directed by Dr. Kaufman is an essential component of this Program Project, providing logistic and strategic supp...
Project 1: Control of NASH to HCC progression by the NRF2-FBP1 tug-of-war
PROJECT SUMMARY – PROJECT 1 Project 1 is striving to understand the role of transcription factor NRF2 and the gluconeogenic enzyme fructose bisphosphate phosphatase 1 (FBP1) in NAS...
Project 2: The UPR transducer ATF6 drives HCC in response to metabolic stress
PROJECT SUMMARY -PROJECT 2 Hepatocellular carcinoma is (HCC) is the most common primary liver cancer and 3rd leading cause of cancer deaths worldwide. HCC etiology is rapidly chang...
Project 3: Metabolic stress induces mitochondrial dysfunction through STARD1 and SAB leading to HCC
PROJECT SUMMARY – PROJECT 3 The incidence of NASH-driven HCC is expected to increase worldwide due to its association with the obesity and type-2 diabetes epidemic. Chronic ER stre...
Core 1: Metabolomics
PROJECT SUMMARY – CORE 1 The liver is of central importance to whole-body metabolism, with major roles, among others, in glucose and fatty acid metabolism, and cholesterol and bile...
Core 2: Bioinformatics/Biostatistics/Genomics
CORE 2 PROJECT SUMMARY Key to this proposal is the inclusion of Core 2, which encompasses unified support for Bioinformatics, Biostatistics, Genomics, Transcriptomics, and Computat...
Addressing Collagen Mediated Protection of Systemic Amyloid Fibrils
Project Abstract The systemic amyloidoses are a family of non-cerebral, protein misfolding disorders in which amyloidogenic precursor proteins aggregate into well-ordered amyloid f...
Evaluation of Commercial Mammography-Based Artificial Intelligence Algorithms for Breast Cancer Risk Prediction in U.S. Screening Populations
PROJECT SUMMARY Women known to be at high risk for breast cancer have opportunities to reduce their risk through primary and secondary breast cancer prevention, including risk-redu...
Conmigo: a multi-level mother-daughter physical activity intervention for pre-adolescent Latinas
ABSTRACT Fewer US Latina girls meet current physical activity (PA) guidelines, with lower rates observed among those from lower-income and less-acculturated backgrounds, contributi...
Social media support groups for adolescent vaping cessation
ABSTRACT Tobacco use causes one third of cancer-related mortality. Decades of tobacco control progress are threatened by the promotion and popularity of e-cigarettes (colloquially...
Partnering to Achieve Wellness for Native Americans through Indigenous Knowledge (PAWNIK)
The proposed project aims to support Tribes and Native American Serving Organizations (T/NASOs) to build capacity for NIH-funded research focused on HEAL (Helping End Addiction Lon...
Promoting algorithmic equity in in-hospital mortality prediction
Project Summary/Abstract In-hospital mortality prediction models (MPMs) are widely used in clinical research and practice; but existing MPMs suffer from algorithmic bias, or system...
TLR Agonist Nano-Immune Therapy for Peritoneal Metastases
Summary Peritoneal metastases are present at diagnosis in 57% of women with ovarian cancer and 8% of patients with colorectal cancer. Peritoneal metastases have been considered a t...
Neuron vasculature interactions in pain
Neuropathic spontaneous pain, a main symptom of neuropathic pain, is often a particularly intractable clinical problem. While much has been done to understand the sensory sensitiza...
Developing strategies to identify candidate individuals for early genetic therapies
ABSTRACT The current state of genomic diagnostics allows us to diagnose genetic disease early in life either by 1) identifying carrier status for inherited diseases before concepti...
Next Generation Immunotherapies for Pediatric Cancers
PROJECT SUMMARY Since the 1990s, pediatric oncology has made sustained strides in understanding the biology that drives children’s cancers, but these understandings have not yielde...
APOL1 as a model to quantify and identify environmental modifiers of genetic associations in diverse populations
PROJECT SUMMARY Complex human traits and outcomes have substantial genetic and environmental contributions that, when identified, lead to a better understanding of underlying biolo...