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606,025 grants found
Showing 25,381 – 25,400 of 606,025 grants
Investigating ethyl lactate as a green solvent - processes, performance and air quality impacts
Solvents have long been recognised as comprising most of the waste produced in the pharmaceutical industry. There is a need to move to more sustainable solvents, as judged consider...
End-to-End Deep Reinforcement Learning for Autonomous Racing
Autonomous racing provides a fast-paced and demanding platform for testing and advancing autonomous vehicle technologies. Unlike conventional road driv- ing, the competitive enviro...
Exploring the diversity and evolution of CO2 fixation in macroalgae and seagrass to understand their response to a changing climate
Macroalgae and seagrass are keystone organisms in essential coastal ecosystems along the UK and global shorelines.However, our understanding of how they fix CO2 and the type of spe...
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Development of accurate diagnostic methods for Saprolegniosis for salmonid aquaculture
The disease saprolegniosis is a major problem in the aquaculture industry with losses of up to 10% of fish caused by the oomycete pathogen Saprolegnia parasitica. As with all patho...
Intermittent fluctuation statistics in spherical tori
Heat and mass transport in a tokamak plasma is primarily influenced by turbulence. Despite progress, there isn't a reliable model to predict confinement in tokamaks. To unders...
Development and validation of reduced models for transport in spherical tokamaks.
Creating a complete and accurate digital model of a Fusion Tokamak is an alluring goal, allowing design decisions to be evaluated and iterated upon.This is particularly important f...
Personal Cooling Garments to Protect at-Risk Patients from Extreme Heat Waves
Personal Cooling Garments to Protect at-Risk Patients from Extreme Heat Waves Project Summary/Abstract Global warming is resulting in more intense, more frequent, and longer period...
A novel, pleiotropic oral drug class that inhibits gut migration of activated T cells
ABSTRACT Inflammatory bowel disease (IBD) is a lifelong inflammatory condition of the gut in which modulation of the immune system is the major therapeutic strategy. However, despi...
NanoLuciferase-based AD/ADRD Microphysiological Systems Platform for High-throughput Screening
Abstract Alzheimer Disease (AD) is characterized by b-amyloid (Ab) accumulation, neurofibrillary tangles (NFTs), neuroinflammation, and widespread neuronal and synaptic loss. To da...
Establishment of a First-in-Class Biocompatible and Efficient Cryopreservation Technology Platform for the Next Generation of Cell-Based Therapeutics in Regenerative Medicine and Drug Discovery
SUMMARY Previous support from NIH SBIR and Coulter Foundation awards allowed the CryoCrate team to develop a first- in-class biocompatible cryopreservation medium product, trademar...
Co-use of cannabis and prescription opioids in emerging adults in medical settings
The transition from adolescence to adulthood is characterized by increased rates of prescription opioid use and related problems. These rates may be even higher among emerging adul...
Comparison of the DNA recognition and genome packaging mechanisms used by true viruses and novel selfless viruses
This project will unravel the molecular, biochemical and structural details of the mechanisms used by viruses to recognize their own genome and to package it into the viral capsid....
Combinatorial geometry and topology of discrete groups
This project will use combinatorial techniques from algebraic topology and geometric group theory to study discrete groups. It will start with using discrete more theory to study t...
Multi-Resolution Docking Methods for Electron Microscopy
Summary In the past decade, we have witnessed revolutionary progress in the attainable resolution of macromolecular assemblies via cryo-electron microscopy (cryo-EM) and in the dev...
The role of norepinephrine transporter phosphorylation in amphetamine reward
SUMMARY Substance use disorder (SUD), including use of the psychostimulant amphetamine (AMPH) and its congeners, is on the rise, especially in the Covid-19 pandemic era. There are...
Unraveling the systemic manifestations of pulmonary arterial hypertension on lean muscle mass
Project Summary While pulmonary arterial hypertension (PAH) is a progressive disease of the pulmonary vasculature associated with high morbidity and mortality, it also has multiple...
Biophysical force affects type 1 alveolar epithelial cell-mediated regulation of the pulmonary matrisome and lung development
PROJECT SUMMARY/ABSTRACT This proposal delineates a five-year individualized training plan that will promote an independent scientific career to study the pathogenesis of bronchopu...
Novel methods for estimating the prevalence of drug use among older adults
Drug use among older adults has increased sharply over the past decade. The combination of the aging and increasing use of psychoactive drugs, including misuse of prescription psyc...