Browse All Grants
606,025 grants found
Showing 25,401 – 25,420 of 606,025 grants
Sex-based study of chronic hypoxia-related vulnerability to depression: age effects
Risk for major depressive disorder (MDD) risk increases with aging. Later-life depression affects 12-40% of people over 65yrs old, with biological risk factors including female sex...
Dysregulation of amyloid-β metabolism by impaired METTL3-m6A signaling in Alzheimer's Disease
Deposition of amyloid plaques is a major pathological hallmark in brains of Alzheimer’s disease (AD). Excess accumulation of amyloid-β (Aβ), caused by increased Aβ production and i...
Uncovering the Mechanisms that Promote and Maintain Germ Cell Identity
Project Summary/Abstract Germ cells have the potential to generate every cell type in the body. Specified in the embryo, germ cells face the challenge of protecting and maintaining...
High-resolution 3D tracking of social behaviors for deep phenotypic analysis
Project Summary The aim of this proposal is to plan for and deliver a proof-of-concept solution for an innovative and easy-to-use experimental platform for measuring and quantifyin...
Decentralized clinical trial of contingency management digital therapeutic to treat stimulant use disorder
Abstract With no FDA-approved medications available to address stimulant use disorders (StUD) and rising prevalence of stimulants nationally, contingency management (CM) has gained...
The effects of poverty reduction intervention on health outcomes among women and young children in low- and middle-income countries
ABSTRACT Poverty long has been recognized as an important social determinant of health. Despite many years of progress, in 2018 nearly 10% of the world's population lived in e...
Role of mitochondrial Complex I deficiency in Alzheimer disease and dementia
Summary Alzheimer’s disease (AD) and dementia present enormous social and economic burdens to the United States. In 2019, AD was recognized as the sixth leading cause of death (121...
Resource of zebrafish models of human diseases
PROJECT SUMMARY/ABSTRACT The diagnosis of rare diseases has seen enormous gains from the advent of whole-exome and whole-genome sequencing as clinical diagnostic tools. However, du...
Understanding the Neurophysiology of Ankle Instability to Improve Rehabilitation Outcomes
Understanding the Neurophysiology of Ankle Instability to Improve Rehabilitation Outcomes Abstract Chronic ankle instability is a common debilitating orthopedic condition that disr...
Prescription of Step Counts for Targeted Changes in Body Composition and Cardiometabolic Risk in Overweight/Obese Adults
The prevalence of overweight and obesity remains epidemic in the United States, with some of the highest rates seen in older adults. While this phenomenon is certainly multifactori...
Collaborative Research: Ideas Lab: The HBCU Ujima Collective: Building Research Capacity at HBCUs through a Grow Your Own Research Corps Model
This Ideas Lab project is a collaboration between Miles College, Howard University, Morgan State University, Tennessee State University, and Winston-Salem State University. The tea...
Collaborative Research: Promoting Meaningful Collaboration in a STEM + Medicine Learning Ecosystem
While integrated science, technology, engineering, mathematics, and medicine (STEMM) learning is gaining popularity in informal learning environments, it remains less common in for...
Low-loss Bi-directional THz Couplers to Enable Affordable MAS-DNP-NMR
Low-loss Bi-directional THz Couplers to Enable Affordable MAS-DNP-NMR Abstract The critical importance of solid-state NMR (ssNMR) was demonstrated by yielding the first atomic-reso...
Expanded SPF breeding colony housing at the Emory National Primate Research Center
Abstract The robust nonhuman primate (NHP) SIV/AIDS research portfolio at the Emory National Primate Research Center (ENPRC), which reached $23.8 million in FY2023 alone, has place...
Application of a novel dCasNano-based Epigenetic Editing to Treat Rett Syndrome
Abstract Rett Syndrome is a devastating neurodevelopmental disease caused by loss of function mutations of the MeCP2 gene, located on the X chromosome. Affecting nearly 20,000 girl...
Development and Validation of a CNS Organoid Model of Temporal Lobe Epilepsy for Drug Discovery
Project Summary/Abstract Microglia-induced neuroinflammation (MiN) plays a critical role in many neurological disorders, contributing to disease progression and symptomology. In Te...
Are Ending the HIV Epidemic goals attainable across race/ethnic groups, risk groups, and settings?
Project Abstract In collaboration with the Shelby County Health Department, which has jurisdiction over Memphis as well as rural northwest Mississippi and Arkansas, we propose to i...
Development of a behavioral economic Intervention to improve HIV-related behaviors among sexual minority men.
Abstract Sexual Minority Men (SMM), particularly SMM 18-34-years old are disproportionately affected by HIV in the United States (U.S), accounting for 68% new HIV diagnoses in the...
Develop a novel strategy to deliver N-acetylcysteine for AD treatment
PROJECT SUMMARY After decades of intensive research and drug development efforts, there are still no cures or substantially effective treatments for Alzheimer’s disease (AD). Curre...
Developing A Diverse Workforce: Advancing Data Science for Addiction Research and Professional Training (ADAPT)
Project Summary As we work to build addiction data science literacy, our field could benefit from increased diversity of background and perspectives in the workforce. The complexit...