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606,025 grants found
Showing 25,121 – 25,140 of 606,025 grants
Tspan14 expression and function in cardiovascular disease
PROJECT SUMMARY/ABSTRACT Genetic predisposition is a significant risk factor for coronary artery disease (CAD), the leading cause of mortality. Most CAD risk variants identified in...
Functional amyloid formation in streptococcus mutans
ABSTRACT Dental caries, the most common microbial disease, is caused by overgrowth of acidogenic and aciduric bacteria including Streptococcus mutans. Childhood caries incidence in...
Hawaii N CREW Research Resource Center
Native Hawaiians, the Indigenous people of Hawaii, have a rich cultural background yet continue to face challenges resulting in significant disparities in addiction and chronic pai...
Extreme Weather Impacts on Children's Acute and Chronic Health Outcomes: A Multi-Site Study with Evaluation of Vulnerabilities
PROJECT SUMMARY/ABSTRACT Climate change-related extreme weather – extreme heat, heatwaves, and intense rainfall – pose an urgent threat to public health. Children may bear a dispro...
CD45 mediated regulation of PMN function during intestinal inflammation
Abstract: It has been well documented that disease activity in inflammatory mucosal diseases including inflammatory bowel disease is linked to the transepithelial migration of neut...
The impact of peripheral injury on central vestibular pathways
The vestibular system is crucial for postural control and the perception of head and body movement in space. Older adults and those with neurodegenerative disease often are affecte...
UIC Building Interdisciplinary Research Careers in Women's Health Program
This Supplement proposes to extend the ongoing support for two individuals through the end of the UIC BIRCWH grant period. One individual is a Hispanic physician scientist who was...
Comparative effectiveness study of current treatments in children with Chronic Nonbacterial Osteomyelitis (CNO)
Project Abstract Chronic nonbacterial osteomyelitis (CNO), also known as chronic recurrent multifocal osteomyelitis (CRMO), is a severe autoinflammatory bone disease of unknown cau...
Hormones and Genes in Women's Health: From Bench to Bedside
PROJECT SUMMARY/ABSTRACT Women and men are at different risks for disorders that occur at different stages of the lifespan from development through aging and their sex differences...
WISP3 and Progressive Pseudorheumatoid Arthropathy of Childhood
Novel strategies are needed when standard approaches fail to delineate mechanisms by which mutations cause disease. This is the case for Progressive Pseudorheumatoid Arthropathy of...
The Role of the Urban/Rural Divide and Socioeconomic Factors in the Incidence, Outcomes and Post-partum Care of Hypertensive Disorders of Pregnancy
PROJECT SUMMARY/ABSTRACT In this proposal, we will quantify disparities in incidence, short- and long-term outcomes, and barriers to post- partum care in women with hypertensive di...
Indole Metabolites as Xenobiotic Danger signals in Acute Lung Injury
ABSTRACT This application is for an NHLBI R01 entitled “Indole Metabolites as Xenobiotic Danger Signals in Acute Lung Injury.” I am a physician in Pulmonary and Critical Care Medic...
Supporting the Tufts BIRCWH Program with an Additional Scholar Position
There is a demonstrated need to increase the number of exceptional researchers in women's health and sex/gender differences to better understand basic mechanisms of disease an...
UCSF-Kaiser Department of Research Building Interdisciplinary Research Careers in Women's Health (BIRCWH) Program
ABSTRACT This administrative supplement proposes K12 and postdoctoral scholar funding for the University of California, San Francisco (UCSF) and Kaiser Permanente Northern Californ...
The Role of SoxE Transcription Factors in Neural Crest Cell Specialization
Project Summary/Abstract Neurocristopathies are a class of syndromes that are predominately characterized by malformations in the craniofacial complex. These defects are caused by...
PHASE I AWARD - AN ORGAN-ON-VASCULARNET MODEL FOR IN VITRO EVALUATION OF RADIATION AND DRUG THERAPIES
There is an urgent need for near physiological organ-on-chip models that can replace testing in animals for human drug development.The Organ-on-VascularNet platform is a 3D organoi...
Topic 464 Phase I Award: Network-Based Multimodal Data Analysis Cloud Software for Cancer Biomarker Discovery and Drug Development
Sostos LLC will deliver cloud-based multimodal data analysis software enabling users to discover biomarkers and develop new/repositioning drugs to improve cancer outcomes.Current m...
FY24 SBIR Phase 2 RD Contract - Topic 431 Light Research, Inc.
Oral and oropharyngeal squamous cell carcinoma (OSCC), ranking as the sixth most prevalent cancer globally, is especially prevalent in low- and middle-income countries (LMICs).The...
TOXICOLOGY STUDIES IN RATS AND DOGS ADMINISTERED AIT-102
The objective of this task order is to conduct toxicology studies in rats and dogs administered AIT-102 to support preclinical research.Any target organ toxicity seen in animals th...
FY24 SBIR PHASE IITOPIC NO. 434PROJECT TITLE: NOVEL NIST TRACEABLE IONIZATION CHAMBER FOR FLASH DOSIMETRY
One of the major factors limiting pre-clinical and clinical use of FLASH RT is the difficulty in measuring FLASH irradiation beam parameters such as dose, dose per pulse, pulse rep...