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606,025 grants found
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Addressing cancer disparities in Nigeria through Immuno-oncology Research – The NOLA Program
PROJECT SUMMARY – OVERALL In the US and other high-income countries, immunotherapy is transforming the management of some cancers, including colorectal cancer (CRC). However, immun...
Administrative Core
PROJECT SUMMARY/ABSTRACT – ADMINISTRATIVE CORE The Administrative Core of the Nigerian Immuno-Oncology Research (NOLA) program will provide centralized scientific leadership, exper...
Research Project
PROJECT SUMMARY/ABSTRACT – RESEARCH PROJECT Outcomes for cancer patients in low- and middle-income countries (LMIC) like Nigeria are poor compared to high-income countries (HIC). A...
Massachusetts Outcomes Study of Assisted Reproductive Technology Equity
Project Summary Given the persistently stark racial/ethnic disparities in perinatal health outcomes in the U.S. and the increasing utilization of fertility treatment to achieve pre...
Telemedicine Use Among Assisted Living Residents with ADRD: Assisted Living, Market, and State Regulatory Factors
Project summary: Today, assisted living communities (ALs) are a popular choice for older adults who can no longer maintain an independent lifestyle at home. However, ALs generally...
Ecosystem for Multi-modal Brain-behavior Experimentation and Research (EMBER)
PROJECT SUMMARY Neuroscience research has historically relied on observing tightly controlled behaviors in siloed laboratory experiments, constraining our understanding of the neur...
The role of antiretroviral therapy in susceptibility to oral human papillomavirus (HPV) infection
ABSTRACT People living with human immunodeficiency virus (HIV) infection (PLWH) remain at increased risk of developing head and neck squamous cell cancer (HNSCC) due to oncogenic h...
A Dynamic and Three-Dimensional Human Model of Hypoplastic Left Heart Syndrome to Probe Compromised Cardiomyocyte Proliferation
PROJECT SUMMARY/ABSTRACT Hypoplastic left heart syndrome (HLHS) is a severe congenital heart defect in which the left side of the heart is underdeveloped, with structural malformat...
Linking Mitochondrial Calcium to Histone Methylation Underlying Lung Regeneration
PROJECT SUMMARY/ABSTRACT Chronic Respiratory Diseases (CRDs) are the third leading cause of death and disability in the United States, with a significant impact on the sociobiologi...
Epigenetic and Neuronal Mechanisms of MECP2 Reactivation to rescue Rett Syndrome
PROJECT SUMMARY/ABSTRACT Rett syndrome (RTT) is a debilitating neurodevelopmental disorder without cure. RTT is characterized by cognitive impairment, seizures, and loss of intenti...
Gadusol: An ancient sunscreen that protects metazoan development
Project Summary Sunlight, while essential for life on earth, also produces harmful ultraviolet radiation (UVR) that penetrates the ozone layer. UVR, particularly UVB, is known to d...
The impact of vaginal washing on cervical inflammation: a randomized controlled trial of women from sub-Saharan Africa at high risk for HIV acquisition.
Project Summary Vaginal washing is a common practice that many women perceive as hygienic. However, vaginal washing has been linked to adverse reproductive health outcomes includin...
A Dose Expansion Study of SX-682 Alone and in Combination with Decitabine in MDS Patients
Myelodysplastic syndromes (MDS) are genetically and morphologically diverse hematopoietic neoplasms that arise from a small pool of mutant clones within hematopoietic stem and prog...
Combating HIV Stigma in Healthcare Settings: A Standardized Patient Approach
40-years into the pandemic, stigma remains the most challenging barrier for HIV prevention. A quarter of people living with HIV remain untested, depriving them of opportunities to...
Mechanistic Evaluation of Macrocyclic Diterpenoids with Selective Triple Negative Breast Cancer Activity
PROJECT SUMMARY Triple-negative breast cancer (TNBC) is a highly heterogeneous disease largely devoid of targeted therapy due to the absence of estrogen, progesterone, and HER2 rec...
Investigation of the renin-angiotensin system at the maternal-fetal interface.
PROJECT SUMMARY There is evidence from human and animal studies that support that imbalance in the renin-angiotensin system (RAS), specifically reduced ACE2 protein levels and/or a...
Scaling health and bioscience training technology to informal education
PROJECT SUMMARY This Project aims to build on the previous Phase I interactive digital media (IDM) product, Model It!. Model It was a product that spun out of the University of Neb...
4/7-PsycheMERGE: Advancing Precision Psychiatry
PROJECT SUMMARY Psychiatric disorders remain a leading cause of disability in the US and are associated with increased morbidity and mortality. Early detection and treatment is ess...
Creating a state-level policy data dashboard to facilitate research on reproductive health
The study of state-level Sexual and Reproductive Health (SRH) policies and their impact on health outcomes is hindered by the absence of a comprehensive, longitudinal database. The...
3/7-PsycheMERGE: Advancing Precision Psychiatry
PROJECT SUMMARY Psychiatric disorders remain a leading cause of disability in the US and are associated with increased morbidity and mortality. Early detection and treatment is ess...