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606,025 grants found
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Longitudinal characterization of the role of the mucosal virome and microbiome in juvenile idiopathic arthritis flares
PROJECT SUMMARY/ABSTRACT Juvenile idiopathic arthritis (JIA) is an autoimmune disease characterized by chronic inflammatory arthritis affecting children. It is the most common chro...
Comprehensive assessment of bone quality using clinical photon-counting detector CT
ABSTRACT More than 10 million Americans are affected by osteoporosis, and an estimated 40 million Americans are at risk of osteoporosis from decreased bone mass. In addition to pri...
Studying astrocyte borders using injectable biomaterials
Astrocyte border formation involving proliferative reactive changes in local astrocytes is a conserved feature of many CNS disorders including neurotraumatic, neurodegenerative, ne...
Molecular analysis of the blood-nerve barrier in health and diabetes
PROJECT SUMMARY In most organs, the vasculature is permeable to many blood-borne molecules and cells, but the vessels of the nervous system tightly regulate the movement of ions, m...
A human abuse potential study of kratom
PROJECT SUMMARY/ABSTRACT The escalating use of kratom, an herbal substance with opioid-like properties, has raised significant public health concerns due to its potential for abuse...
Addressing Food Insecurity in Transplant and Cellular Therapy Patients with Healthcare-Community Partnerships
ABSTRACT Food insecurity (FI), defined as a lack of consistent access to enough food for every person in a household to live an active, healthy life due to insufficient money or ot...
Brain CHEC-AC (Brain and Cognitive Health Equity Campaign for Allegheny County)
ABSTRACT Despite being at nearly twice the risk of developing Alzheimer’s or a related dementia (ADRD), Americans identifying as Black or African American are 35% less likely to be...
ACVR1 sensory neuron-specific signaling in neuropathic pain and injury-induced heterotopic ossification
PROJECT SUMMARY Debilitating pain, a hallmark of tissue injury and neuropathy, is an unmet clinical challenge particularly in musculoskeletal diseases, such as heterotopic ossifica...
Maintenance of Human and Animal Food Rapid Response Team - Wisconsin
Project Abstract The efforts undertaken as part of this Cooperative Agreement will further increase the capacity of Wisconsin’s food safety regulatory programs to protect public he...
New Treatment Strategies and Epigenetic Biomarker for Management of BPH
PROJECT SUMMARY: Over 90% of adult males develop lower urinary tract symptoms (LUTS) secondary to bladder outlet obstruction by age 80 secondary to benign prostatic hyperplasia (BP...
Novel Strategies for Understanding and Treating Fibrous Dysplasia
PROJECT SUMMARY The overall goals of this diversity supplement are to develop the candidate’s background in biological and translational sciences and position her to be a strong ca...
Restoring Tolerance in Inflammatory Bowel Disease with an Oral AMPK agonist Nanomedicine that Targets Antigen Presenting Cells.
PROJECT SUMMARY In the United States alone, approximately 3.1 million adult patients suffer from inflammatory bowel disease (IBD), a group of disorders characterized by chronic or...
Cannabis Regulators Association 2024 Annual Member Meeting: Furthering Regulatory Exchange and Collaboration
PROJECT SUMMARY / ABSTRACT Cannabis-related policy changes in the US and abroad have outpaced science and research about the impacts different potential regulatory approaches have...
Exploring nano-bio interactions for cell-specific targeting of osteoarthritis
Exploring nano-bio interactions for cell-specific targeting in osteoarthritis In the US, osteoarthritis (OA) is the most prevalent chronic joint disease. However, there is still no...
ADEPT: Assessing Diversity Effects Post Affirmative Action Restrictions in Medical Schools
ABSTRACT The affirmative action restrictions issued by the Supreme Court of the United States (SCOTUS) on June 29, 2023, significantly limit the use of race-conscious admissions in...
Ano4 and Metabolic Health
PROJECT SUMMARY Obesity is a major risk factor for many chronic medical conditions, including diabetes, cardiovascular disease, depression, and cancer. Elucidating the neural mecha...
Alpha- to Beta-Cell Communication in Health and Disease
Summary of Work Glucagon is canonically viewed as an essential counterregulatory hormone that prevents hypoglycemia by driving endogenous glucose production (EGP) in the liver. We...
The Black Zones: Harnessing Mobile Tech Enabled Community Driven Data, Big Population, Health Data, & Agent-Based Models to Transform the Measures & Metrics around Structural Racism & Black Longevity
Abstract Racial residential segregation (RRS) is a form of structural racism and a key driver of the life expectancy gap for African Americans (AAs) and Black Immigrants (BI) in th...
2025 Myogenesis Gordon Research Conference and Gordon Research Seminar
Abstract This proposal requests partial support for an international meeting on Myogenesis as part of the Gordon Research Conference (GRC) and Gordon Research Seminar (GRS) series...
Neurofibromin 1 as a novel regulator of lipid metabolism
PROJECT SUMMARY High grade gliomas (pHGGs) represent the greatest number of solid tumors in the pediatric population, and now are the greatest cancer related cause of death. Within...