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606,025 grants found
Showing 23,661 – 23,680 of 606,025 grants
Modernizing biology curricula by developing accessible genomic data science miniCUREs for the AnVIL platform
Project Summary/Abstract We propose to develop two short-format, introductory, modular, Course-based Undergraduate Research Experiences (miniCUREs), and deliver this computational...
Understanding and Visualizing Emergency Department Clinician Well-Being and Strain
Project Summary Emergency department clinicians (ECs) regularly experience among the highest rates of psychological distress. Manifesting in poor well-being and burnout, EC psychol...
Functional Genomics of Multiple Hereditary Exostoses
Multiple hereditary exostoses (MHE) is an autosomal dominant disorder that affects one in every 50,000 children worldwide and is characterized by the formation of cartilage-capped...
Statistical Methods for Characterizing Molecular Mechanisms of Human Tissue Development and Disease
Project Summary The unique biospecimens and data from the Developmental GTEx (dGTEx) project create an exciting opportunity and need for novel methods development. In this project,...
Population-Based Outcomes Research for Rheumatoid Arthritis: Rural Health Disparities
PROJECT SUMMARY/ABSTRACT In rheumatoid arthritis (RA), delaying initiation of treatment for ≥12 weeks is associated with irreversible joint damage due to greater difficulty in achi...
Novel data and approaches for dynamic modeling of human behavior and infectious disease ecology
PROJECT SUMMARY Demographic and social forces that influence human behavior fundamentally shape the epidemiology of infectious diseases, but are often left out from mathematical mo...
VCID Center Without Walls for Understanding and Leveraging Small Vessel Cerebrovascular Disease Mechanisms in ADRD
Understanding the pathogenesis of cerebral small vessel disease (CSVD) and vascular contributions to dementia (VCID) is increasingly important to help protect the cognitive and men...
oREgon medicaid policy, SOciaL serVices, and hEalth (RESOLVE)
Project Abstract The circumstances in which people are born, grow, live, and work—often referred to as social determinants of health (SDH)—have well-documented impacts on chronic d...
Brain capillary endothelial cell energetics and neurovascular uncoupling in dementia
Growing evidence suggests the contribution of altered brain microcirculation to cognitive impairment and dementia observed in Alzheimer's disease (AD) and AD-related dementia...
From Impairment to Participation: A Systems Approach to Understanding the Complexity of Aphasia
Project Summary Language is vital to much, if not all, aspects of a person’s life. For those persons with aphasia (PWA), a language disorder, the impact of aphasia extends beyond t...
Attention Regulation Strategies Used by Deaf and Hearing Parents of Autistic Children
PROJECT SUMMARY Difficulties with social communication are among the core impairments of autism spectrum disorders (ASD) and pose significant challenges for the one in 44 American...
Systematic Functional Genomics Analysis of the Oral Pathogen Streptococcus Mutans
Project Summary In this project we will construct a powerful new tool to systematically identify infection-relevant genes in the dental caries pathogen Streptococcus mutans. Sequen...
The MVP Trial: A Randomized Controlled Trial of Mechanism Guided vs PPI Strategy for Laryngopharyngeal Reflux
PROJECT ABSTRACT Among the 20% of US adults experiencing laryngeal symptoms, 80% are diagnosed with laryngopharyngeal reflux (LPR) based on symptoms alone and empirically treated w...
Transcranial stimulation combined with auditory training
Project Summary/Abstract The goal of this project is to investigate the potential of transcranial stimulation to enhance intelligibility in speech mixtures in older adults struggli...
Effects of Aphasia Identification Cards on Comprehension of Aphasic Language by Unfamiliar Communication Partners.
Project Summary/Abstract People with aphasia often experience challenges conveying their thoughts to unfamiliar communication partners, which is critical for living independently a...
Mechanistic underpinnings of pragmatics in ASD: Insights from FMR1-mutation conditions
Project Summary Impaired pragmatic (i.e., social) language is a defining symptom domain of autism spectrum disorder (ASD) and imposes significant burden on affected individuals and...
An innovative approach to cracking odor coding in the piriform cortex
Project SummaryAs the largest cortical recipient of direct olfactory bulb (OB) projections and a prominent part of the rodent brain, the piriform cortex (PCx) is considered to be a...
Pre-clinical testing of a novel gene therapy for pediatric neurodegenerative disease
PROJECT SUMMARY A significant number of pediatric neuromuscular and neurodegenerative conditions are caused by recessive gene mutations resulting in loss of both maternal and pater...
Elucidating the Role of TGF-Beta Signaling in Craniofacial Fibrous Dysplasia of the Bone
PROJECT SUMMARY: Craniofacial fibrous dysplasia (CFD) is a disabling skeletal disease with no curative medical therapies. It is characterized by fibrotic, expansile bone lesions th...
Center on the Ethics of Indigenous Genomic Research
Summary American Indian and Alaska Native (AI/AN) concerns about genomics are well documented but are too often left unaddressed. The failure to authentically engage AI/AN communit...