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606,025 grants found
Showing 23,641 – 23,660 of 606,025 grants
Capacity Building: Compliance Strategy for Digital Dementia Screening
Purpose and goal:The goal of this project is to begin establishing a regulatory strategy that includes developing a comprehensive plan for the approval and marketing of our medical...
Enhancing Sustainable Innovations and Global Engagement through Strategic Newsletter Outreach
Purpose and goal:The newsletters are designed to foster engagement with stakeholders by providing updates on Swedish and European sustainable values and actions globally, informing...
Long-term, non-clinical toxicology for advancing CMS121 to Phase 2 trials for AD
Abstract Our goal is to advance CMS121 to a Phase 2 clinical trial by conducting the long-term non-clinical toxicology studies needed to support a long-term course of daily adminis...
Mechanisms of Chromosome Fragile Site Formation in the Human Genome
PROJECT SUMMARY/ABSTRACT Common fragile sites (CFSs) are recurrent “wounds” in every person's genome that predispose the chromosomes to DNA double strand breaks (DSBs) and rea...
Developing a therapeutic, music-based mobile application to combat neuropsychiatric symptoms in people living with Alzheimer's disease and related dementias
Project Summary More than 6 million people in the United States are living with Alzheimer’s Disease and Related Dementias (ADRD). Music-based interventions have been shown to decre...
Drug repurposing of a novel synthetic progestin for the prevention of preterm labor and fetal inflammation
Abstract Intrauterine infection/inflammation (IUI) is a major contributor to preterm labor and fetal inflammation leading to injury responses in fetal organs such as the brain, lun...
Executive Function Impairments in HAND and Aging
Project Summary: With the great success of combination antiretroviral therapy (cART), older adults (>50-years of age) now account for 30–50% of HIV-1 seropositive individuals in...
Faceting GEMs (Genomics Education Modules) for the Entry-level Workforce
Project Summary/Abstract Rapid advancements in genomics have revolutionized healthcare, technology, research, and beyond. The demand for professionals with genomics skills, knowled...
Self-regulation of real-time fMRI brain activity in chronic pain: A potential neurobiological mechanism of cognitive behavioral therapy
Project Summary/Abstract Self-regulation is the ability to manage one’s thoughts, emotions, and behaviors to achieve desired goals through a variety of cognitive and emotional proc...
Understanding Mechanism of Functional Dynamics Through An Explainable Neural Network Landscape with Geometric Control
Project Summary/Abstract One of the fundamental scientific problems in neuroscience is to have a good understanding of how cognition and behavior emerge from brain function. Tremen...
Exposure to Metal-Mixtures and Coronary Heart Disease Across Diverse Populations
Coronary heart disease (CHD) is the leading cause of mortality and disability worldwide, and accounts for 13% of global deaths and 370,000 deaths annually in the US. Accumulating e...
Animal free alternatives to the study of nutrition in early pregnancy
Doctoral Training Partnerships: a range of postgraduate training is funded by the Research Councils.For information on current funding routes, see the common terminology at https:/...
Neural Mechanisms for Auditory Memory Sequencing and Prediction
Human and nonhuman animals rely on memories of the past to anticipate the future, weighted by the reality of the present in our ever-changing sensory world. As universal as it is f...
Development and preliminary testing of a peer narrative video intervention for older adults with chronic pain
Chronic musculoskeletal (MSK) pain, which includes spinal pain, osteoarthritis, and fibromyalgia, is a common and costly problem for older adults and is associated with decreased q...
Advancing High-Resolution Charge Detection-Mass Spectrometry
Project Summary Charge detection mass spectrometry (CD-MS) is an emerging technology that allows accurate mass distributions to be measured for heterogeneous and high mass samples....
Autoantibodies to membrane repair proteins in myositis
Project Summary Idiopathic inflammatory myopathies (IIM) are a group of inflammatory disorders characterized by muscle weakness and are associated with significant morbidity and mo...
Mechanisms of Reverse Transendothelial Migration in Arthritis Resolution
3. Abstract Inflammation is a beneficial response to infection or tissue damage and mediates the removal of microbial pathogens and restoration of the tissue to homeostasis. Occasi...
Gait as a Preclinical Marker for Alzheimer’s Disease and Dementia: insights from super-movers, usual-movers, and slow-movers
Emerging research implicates gait dysfunction as a preclinical marker of Alzheimer’s disease and related dementias. Our team has been in the vanguard of gait and cognition research...
Neural mechanisms of gait disturbances as individualized digital biomarker trajectories in preclinical dementia
PROJECT SUMMARY Alzheimer's disease and related dementias (AD/ADRD) rank prominently among age-associated neurodegenerative disorders, with Parkinson’s disease trailing as the...
Diagnostic identification of language and reading disorders among bilingual learners
A major problem in research and practice is that bilingual students in the U.S. are often misidentified having language and reading disorders. Both over- and under-diagnosis of dis...