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Control of DNA Replication by Protein Dephosphorylation: the Role of Protein Phosphatase 1 and its Regulatory Interactors
DNA replication is central to life, with defects in this process a major cause of disease. Decades of study have revealed how phosphorylation of the replication machinery drives re...
Targeting UTR regulation as a gene-level therapeutic strategy for rare disease
Rare disorders are a major cause of mortality and morbidity and collectively affect over 300 million people worldwide.The UK is a world leader in genetic diagnosis, with the NHS pr...
Measuring the global impact of climate change on human health at a local sentinel site
Climate change is an existential threat, but we have little data describing its direct impact on human health.Coastal populations in Bangladesh affected by rising sea levels and el...
Developing a systematic framework for reconstructing evolutionary histories of viruses with pandemic potential
The accurate estimation of molecular clock rates is crucial for characterising virus evolutionary dynamics and reconstructing their natural history.While modern sequencing software...
Elucidating monocyte-specific disease mechanisms in systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is a devastating autoimmune disease that disproportionally affects young women, particularly those from ethnic minority groups.Lupus nephritis (L...
Validating myo-inositol, a novel renal biomarker for kidney disease.
Kidney diseases are a major global health concern. Early diagnosis and timely treatment are important for improving clinical outcomes.However, the existing creatinine-based diagnos...
Probing variation in viral proteomes through interaction profiling and structural modelling
Protein structure
Bureaugraphies. Administration After the Age of Bureaucracy
Literatur
Evaluating the impacts of climate and environmental stressors on migration and migrant health in Brazil
Climate and environmental change are key drivers of human displacement and migration, which may compromise the physical and mental health of affected populations.The deleterious im...
Removing barriers to advanced imaging and machine learning-based analysis
While imaging and image analysis technologies have undergone dramatic technological leaps in the last decade, progress has been uneven at the global scale(1).Although some groups a...
Enhancing islet and beta-cell transplant engraftment by targeting chemokine-driven inflammation
Immune cell mediated beta-cell destruction results in only 50% of islet transplant recipients remaining insulin independent at 5-years. Therapeutics targeting immune cells are succ...
Exploring miRNA heterogeneity within pancreatic beta-cell subpopulations to improve beta-cell therapies
Pancreatic β-cells within islets are molecularly and functionally heterogeneous.Single-cell RNA sequencing (scRNA-Seq) has revealed distinct β-cell subpopulations with unique trans...
Brain cells for beta cells
The proposed research aims to investigate the potential of choroid plexus epithelial cells (ChPECs) as a novel cell therapy for Type 1 Diabetes (T1D).ChPECs, known for their secret...
Beyond Bacteria
This annual meeting is organised by a rotation of microbiologists from different universities in the Netherlands. Besides Amsterdam, this meeting has so far been held in Groningen,...
A mechanism for persistence and resolution of anxiety after exposure therapy
Exposure therapy is the most effective treatment for anxiety disorders. However, even after successful treatment, with time many experience spontaneous recovery of fear and even fu...
Protection Against Invasive NTS Disease (PAINTS) - correlates of protection towards vaccine licensure
Invasive Non-Typhoid Salmonella (iNTS) disease is a high-burden high-fatality bloodstream infection across Africa, associated with young age and malaria.Two candidate-vaccines (con...
Computational Electrochemistry: Towards the Understanding of Electrolytes at the Molecular Level
machine learning
Quantum metamaterials
quantum optics
Resolve Swiss
Disability
A Holistic View of Gene Expression in Archaea
Archaea represent an understudied yet abundant and important group of prokaryotic organisms.Their gene expression machinery is a streamlined version of pol II, including RNA polyme...