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Host-microbial interactions in oral mucosa immunopathology
Neutrophils are crucial for oral homeostasis but are also drivers of tissue damage in periodontitis, a common oral immunopathology. The mechanisms determining a protective or detri...
Unraveling Lipoprotein Maturation and Transport Pathways in Gram-Negative Bacteria: Pioneering Targets for Innovative Antibacterial Therapies
The escalating challenge of antimicrobial resistance underscores the urgent need to identify novel targets for antibacterial drug development.Despite the vast diversity of bacteria...
Non-motor symptoms and complications in Parkinson´s disease: modeling and identification of targets for therapy
The goal of this Research Project is to study non-motor symptoms associated with Parkinson’s disease (PD) and whith complications caused by dopamine replacement therapies.Psychiatr...
Interaction between sex steroids, physical exercise and metabolism in female reproduction and health
Reproductive dysfunction is frequent in women with hyperandrogenism and obesity, like polycystic ovary syndrome (PCOS). On the other hand, hyperandrogenism can be beneficial for ph...
Restoring immune fitness through biophysical manipulations
While the identification of “cell types” often relies on well-defined surface markers or transcriptional repertoires, characterizing “cell states” proves to be a more nuanced chall...
Molecular mechanisms of TGFbeta signaling
Our aim is to elucidate molecular mechanisms involved in TGFb signaling in breast cancer.TGFb has both tumor suppressor (inhibits growth and induces apoptosis) and tumor promoting...
Rational design of copper electrocatalysts with tailored distribution of facets for the production of fuels (ElectroFuel).
Copper is an active catalyst for the electrochemical hydrogenation of carbon-containing molecules to produce liquid fuels. Copper can convert carbon dioxide (CO2), a greenhouse gas...
On-surface synthesis of graphene nanoribbons on non-metals studied by large-scale computational modeling
The project will predict synthesis routes of graphene nanoribbons (GNRs) on non-metal surfaces, crucial for advancing semiconductor applications.GNRs, distinguished by tailored sem...
Post-fire recruitment, microbial communities and ecosystem shifts in the Boreal forest
An increasing number of extreme boreal wildfires are leading to greater carbon (C) emissions, affecting the Earth’s climate. Post-fire recruitment of tree seedlings is key for sust...
Noggrann Analys av de Molekylära Mekanismer som Sker vid Svar på Syrebrist
Low oxygen (O2) conditions profoundly affect animals’ behavior and physiology, and underlie the pathogenesis of various human disorders. However, the fundamental mechanisms underly...
Advancing the theory of Progressive Nitrogen Limitation in boreal forests: consequences for the global carbon cycle
Boreal forest growth has increased over the past century; however, it remains uncertain whether growth will continue to increase.It is hypothesized that higher CO2 may cause nitrog...
Unravelling resistance evolution using liquid biopsies
A major challenge in medicine, especially cancer treatment is the emergence of resistance to therapy.Blood-based, or liquid, biopsies present an unprecedented opportunity to gain n...
Obese yeasts as models for eukaryotic lipid metabolism
We aim to establish the oleaginous yeast Rhodotorula toruloides as model for eukaryotic lipid metabolism. Lipid metabolism is a vital part of metabolism in all kingdoms of life. In...
When health education becomes unhealthy: An exploration into Orthorexia Nervosa in Swedish schools
Health-related school subjects in Sweden address different health topics, including healthy eating. Healthy eating is something that many people aspire to, mainly for health reason...
Structure, dynamics and applications of negative ions
The purpose and aim of this proposal is to develop novel experimental techniques and conduct key experiments on atomic and molecular negative ions. The experiments will be conducte...
Origin, adaptive significance and underlying mechanisms of toxicity in birds and frogs
Despite knowing for decades that some birds and frogs eat prey containing the same potent neurotoxins (Batrachotoxin – BTX), there is a major gap in our understanding of how these...
Harnessing Chaos for Chemically Recyclable Biocomposites
I propose a new paradigm in step-growth polymerization based on increasing entropy (chaos) in the system instead of classical small molecule removal.This paradigm enables me to syn...
MicroRNAs as regulators of gene- and tissue-specific stop codon readthrough
Stop codon readthrough (SCR) refers to when the ribosome surpasses a stop codon, leading to the synthesis of elongated protein isoforms. Our recent study established the functional...
Impact of softness of individual colloids on the shear banding in soft glassy materials
We will understand the role of the softness of an individual colloid on the structuring and macroscopic properties of a suspension under flow.Suspensions of microgels (soft deforma...
Biocatalytic cascades for the surface functionalization of lignocellulosic fibres
Lignocellulosic fibres are attractive materials that can replace traditional fossil-based products due to their unique functional properties.Lignocellulosic biomass consist of a ne...