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606,025 grants found
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Durable Solutions in Kosovo for Returnees
To enhance durable solution opportunities for returnees by strengthening local level capacity.
Exploring Mechanisms Linking Maternal Childhood Adversity to Adolescent Psychopathology: The Role of Early Childhood Deprivation and Threat
Project Summary This developmental R21 study proposes a secondary data analysis addressing specific questions regarding the mediating pathways by which childhood maltreatment (CM)...
Targeting proton-sensing GPR68 as a ferroptosis-based therapy for glioblastoma
Glioblastoma (GBM) is the most common primary brain cancer in adults. Over 10,000 people are estimated to die yearly from GBM despite aggressive treatment, and there has been no su...
Influence of the Cervicovaginal Phageome on Health and Disease in Women Living with HIV.
PROJECT SUMMARY/ABSTRACT The female reproductive tract (FRT) microbiome consists of all microbes within that space, including the bacteriome and the virome, which is comprised of t...
Chimera-BONCAT: A novel in vivo model for in-depth characterization of the human microglial response to alcohol
ABSTRACT Alcohol use disorder (AUD) is a significant health crisis in the U.S., which can result in numerous damaging effects on multiple organ systems including the brain. Althoug...
Noninvasive and early detection of endometriosis using a biological neural circuit-based novel gas sensor
PROJECT SUMMARY Endometriosis is a chronic inflammatory estrogen-dependent disease, and it affects approximately 10-15% of women of reproductive age. Definitive diagnosis of endome...
Risk, Resilience, and Recovery: A Longitudinal Mixed-Method Study Examining the Role of Peer Relationships in Pediatric Pain
Project Summary/Abstract Pediatric chronic pain is a critical public health problem, affecting up to a third of adolescents and contributing to significant emotional distress, poor...
In vitro and in silico investigations of changes in bacterial cell membrane dynamics due to polyunsaturated fatty acid (PUFA) modifications
Project Summary/Abstract Bacterial responses to fatty acids include, but are not limited to, degradation for metabolic gain, modification of membrane lipids, alteration of protein...
Converting methane into green fuels using electrochemical devices
This proposal titled ""Converting methane into green fuels using electrochemical devices (COMFUELS)""will achieve efficient electrochemical methane conversion i...
Electrical Field Guided TMS and Constraint Induced Language Therapy to TreatPost-Stroke Aphasia in the Subacute Stage
Project Summary Transcranial Magnetic Stimulation (TMS), sometimes in conjunction with Speech-Language Therapy, has been demonstrated to improve language function in subjects with...
Single cell multi-omics approaches in identifying driving cells and genes in pediatric MODS patients requiring ECMO support
PROJECT SUMMARY My long-term goal is to develop innovative diagnostic and therapeutic methods for pediatric diseases in the intensive care unit (ICU), using cutting-edge single-cel...
Psychophysical distillation of pure pain by nociceptive-specific heating
Project Summary: Experimental pain testing in humans, including both quantitative sensory testing (QST) and functional magnetic resonance imaging (fMRI), is widely used to make inf...
Air Pollution and Mortality Risk in Veterans with Chronic Respiratory Disease: Assessing the Role of Individual and Place-Based Risk Factors
PROJECT SUMMARY/ABSTRACT Chronic respiratory diseases (CRD), such as asthma and chronic obstructive pulmonary disease, impact over 554 million people worldwide and are major contri...
Increasing Access and Participation to Early Phase Clinical Trials to the Underrepresented Populations
Project Summary Access to health care including clinical trials leading to paradigm-changing cancer treatments is critical for high quality cancer care and equity in society. Diffe...
Hormonal Programming of the Mesocorticolimbic Circuit During Adolescent Development
Abstract Adolescence is a critical period for the development of a range of mental health conditions in females and males, particularly those marked by impairments in cognitive con...
A Comprehensive qPCR-Based Oral Microbiome Profiling Platform for Research and Discovery
The oral microbiome plays a crucial role in dental health and can offer insights into a wide variety of systemic conditions. Next-generation sequencing (NGS) has been used to study...
Identification of HIV Rev-Rev interaction inhibitors by a high throughput, small molecule, cell-free screen
The HIV pandemic has grown to ~40 million individuals world-wide. Although Highly Active Anti- Retroviral Therapy (HAART) has been transformative for millions of people, less than...
Ionic liquid-based nanoemulsion containing combination antiretroviral drugs forthe transdermal treatment of pediatric HIV infection
PROJECT SUMMARY The effective long-term management of HIV infection in pediatric patients faces a multitude of challenges such as lack of age-appropriate pediatric formulations, hi...
Long-term clinical and immunologic consequences of inflammation in perinatal HIV
Project Summary Globally, 2.7 million children are living with HIV and 270,000 new infections occur annually. With antiretroviral therapy (ART) that suppresses viremia these childr...
HIV Vaccine Design Incorporating Selective Avidity
ABSTRACT VRC01 is prototypical broadly neutralizing antibody (bnAb), capable of neutralizing diverse HIV strains. Vaccine-based shepherding of VRC01 germline-reverted B-cells to th...