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606,025 grants found
Showing 33,641 – 33,660 of 606,025 grants
Testing a Mindfulness-Based Intervention with a Multi-Modal Adaptive Supplement for Stress-Related Problems in College Students
Abstract There have been dramatic and concerning increases in rates of psychological distress in students enrolled in U.S. colleges and universities over the last decade. The major...
Circular RNA Role in Ovarian Follicular Development and Fertility
Project Summary Ovarian follicles undergo a series of dynamic changes following the ovulatory surge of luteinizing hormone including cumulus expansion, oocyte maturation, ovulation...
Evaluating the impact of altered gene expression on uterine fibroid risk in African ancestry populations
PROJECT SUMMARY Uterine fibroids, benign tumors of the uterus, affect 77% of women by menopause in the U.S. and account for up to $34 billion in annual healthcare costs. Black wome...
Open, Extensible, Standardized, and Customizable Computational Tools for Optical Brain Mapping
PROJECT SUMMARY/ABSTRACT We propose to broadly disseminate and extend intuitive, powerful cloud-based resources for optical brain mapping that facilitate efficient, accurate, and s...
IL-22-STAT3-Nos2 axis in alcohol-mediated exacerbation of UC pathology
Project Summary/Abstract Alcohol use is a risk factor in multiple disease conditions including gastrointestinal related diseases. Recent findings from our laboratory show that alco...
Infertility and Long-Term Health Outcomes Among Hispanic Women with Mexican Heritage
PROJECT SUMMARY Hispanic women are up to 70% more likely to experience infertility (i.e., trying to conceive for ≥12 months without success), compared to non-Hispanic white women i...
Mapping postnatal oxytocinergic system and offspring neurobehavior after induced birth with oxytocin
Project Summary/ Abstract Exogenous oxytocin (OT) is widely used for the induction of labor in pregnant women. Though induction of labor with OT confers many maternal and neonatal...
Research grants administration capacity strengthening in South America
PROJECT SUMMARY/ABSTRACT The main objective of this proposal is to improve administrative and financial oversight of NIAID grants and to enhance compliance with regulations that go...
Informing optimal investments along the preconception to postpartum eMTCT continuum
PROJECT SUMMARY/ABSTRACT While expansion of antiretroviral therapy (ART) coverage over the past two decades has significantly decreased mother-to-child, or “vertical,” transmission...
CHCHD10 Frontotemporal Dementia, Molecular Mechanisms and Therapeutic Strategies
Coiled-helix-coiled-helix domain containing protein 10 (CHCHD10, D10) is the first mitochondrial protein to be associated with familial frontotemporal dementia and amyotrophic late...
Cognitive progression among older adults with subjective cognitive decline and mild cognitive impairment: the roles of sleep and physical frailty
PROJECT SUMMARY Individuals with Subjective Cognitive Decline (SCD) and mild cognitive impairment (MCI) are significantly more likely to have increased AD biomarkers (e.g. amyloid...
USDHub: community resource for Urinary Stone Disease research
ABSTRACT Urinary stone disease (USD) is highly prevalent and contributes a substantial proportion of healthcare costs related to kidney and urologic disease. Approximately half of...
Improving IL12 Immunogene Therapy for Glioblastoma Based on Human Clinical Trial Results
PROJECT SUMMARY Glioblastoma (GBM), one of the most fatal of cancers, remains impervious to treatment with the current standard of care (SOC) therapies. Even immunotherapies like i...
Genetics of Osteoarthritis Susceptibility, Heterogeneity and Progression
The societal and patient-centered impacts of osteoarthritis (OA) are profound – total costs for OA treatment in the US exceed $486 billion annually. OA management is limited to sym...
Determining the Genetic Basis of Hidradenitis Suppurativa
PROJECT SUMMARY/ABSTRACT Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease that has a devastating effect on quality of life. HS affects up to 1.2% of people and...
Visualization of extracellular morphogens to understand self-organized patterning
Project Summary During embryonic development, extracellular proteins, known as morphogens, play a key role in conveying positional information and establishing cell fates. While th...
An integrated MPS platform with "virtual humans" for chemical toxicity testing
People are exposed to diverse chemicals through food, soil, air, water, consumer and industrial products. Some individuals are more sensitive and/or susceptible than others. The go...
Implementing an Evidence-Based Trauma Treatment with Community-led PrEP Navigation for Transgender and Gender Diverse Individuals Affected by Violence and HIV.
PROJECT ABSTRACT HIV prevalence is high among transgender and gender-diverse/expansive (TGD) individuals in the Ending the HIV Epidemic (EHE) priority jurisdiction of Los Angeles C...
Defective HIV proviruses and Persistent Innate Immune Activation
Abstract/Summary CD4+ T cells and macrophages are infected by HIV and this infection correlates to more proinflammatory activities that drive HIV comorbidities and end organ diseas...
Equipment and Administrative Supplement- THE HARC CENTER 2.0: HIV ACCESSORY AND REGULATORY COMPLEXES
ADMINISTRATIVE SUPPLEMENTS - THE HARC CENTER 2.0: HIV ACCESSORY AND REGULATORY COMPLEXES PROJECT SUMMARY The primary goal of the HARC Center is the structural characterization of e...