Browse All Grants
606,025 grants found
Showing 27,441 – 27,460 of 606,025 grants
The role of cortisol synthesis in pathogenesis of Hidradenitis suppurativa tunnels
Abstract Hidradenitis suppurativa (HS) is a common, debilitating inflammatory disease characterized by unique pathological features that includes epithelialized tunnel formation. C...
Modulating Endogenous Opiate Signaling to Reverse Stress-Induced Deficits in Reward Processing
Project Abstract Millions of Americans suffer from deficits in reward processing, in the context of psychiatric disorders including major depressive disorder and schizophrenia. Dis...
Development of integrated risk models of genetic and non-genetic risk factors in endometrial cancer across diverse ancestries
PROJECT SUMMARY The incidence of Endometrial Cancer (EC) has been rising, with a notable increase in mortality rates, especially among Black women who face a higher risk of aggress...
Integrative Analysis Methods for the dGTEx Initiative
ABSTRACT This research project aims to develop methods and tools and conduct collaborative research for the integrative analysis of data generated by the Developmental Genotype-Tis...
Improving PrEP outcomes among pregnant women in Botswana with an integrated STI testing and PrEP delivery model
HIV incidence remains high for women in Southern Africa and HIV acquisition risk doubles during pregnancy and postpartum compared to non-pregnant periods. HIV pre-exposure prophyla...
Loss of resident donor-derived Tregs and the emergence of monocyte-derived alveolar macrophages leads to acute rejection and chronic dysfunction in lung transplant recipients
PROJECT SUMMARY: Chronic lung allograft dysfunction (CLAD) is the primary driver of morbidity and mortality in lung transplant recipients. Currently there is a need to identify cli...
Role of plasma cells in chronic rejection after lung transplantation
SUMMARY Lung transplantation (LTx) is the only life-saving intervention for many patients with end-stage lung disease. The long-term survival after LTx, however, is severely limite...
Development of an early detection test for Type 1 Diabetes via NGS-based analysis of β cells-specific methylation patterns in cfDNA
PROJECT SUMMARY Type 1 diabetes mellitus (T1D) is a chronic autoimmune disease that affects ~1.5M Americans, characterized by persistent hyperglycemia requiring life-long administr...
Improving cryopreservation outcomes of small biological samples through ultra-fast convective cooling and warming
Project Summary/Abstract Cryopreservation of oocytes, embryos and other small biological samples plays a key role in medicine, in biomedical research, and in assisted reproduction...
Social Comparison on Social Media, Depressive Symptoms, and Body Dissatisfaction among Adolescents
PROJECT SUMMARY Social media (SM) has played an increasingly prominent role in adolescents’ daily lives over the past decade, notably coinciding with increased population prevalenc...
FOSL1-super-enhancers define cisplatin-enriched cancer stem cells in HNSCC
Project Summary/Abstract The chemotherapeutic drug cisplatin is a first-line drug for the treatment of many solid tumors, especially head and neck squamous cell carcinoma (HNSCC)....
Precision imaging of the spatial regulators of the hybrid epithelial/mesenchymal state in head and neck cancer
PROJECT SUMMARY Head and neck squamous cell carcinoma (HNSCC), including oral cavity squamous cell carcinoma (OCSCC) is the sixth leading cause of cancer-related mortality, with th...
Next Generation ELQs for Treatment and Once-Monthly Protection Against Malaria
Project Summary / Abstract The Medicines for Malaria Venture (MMV) recently published a “roadmap” for the types of medicines that are needed to support the long-term goal of malari...
Bridging the gap: joint modeling of single-cell 1D and 3D genomics
Advances in single-cell technologies have enabled three-dimensional (3D) genome structure profiling and simultaneous capture of the transcriptome and epigenome within a cell. Quant...
A Novel Nanodrug for Metabolic Disease Treatment
NOTE: You must submit in Word format, not PDF, for eRA to update all the systems.Metabolic health issues such as metabolic dysfunction-associated steatohepatitis (MASH) and type 2...
Task A05: Collection of Metadata from In Vivo Studies Performed Under Previous IDIQ Contract Mechanisms
This contract provides for the development of new and refinement of existing models of infectious diseases and may include evaluation of candidate countermeasures.
Leveraging forecasts to optimise decision making
The COVID-19 pandemic underscored the need for epidemic forecasts to guide policy decisions on resource allocation, public health measures, and risk communication.However, deriving...
Preventing Diabetic Peripheral Neuropathy Using Technology To Transform Clinical Outcomes
Background: Personalised medicine in diabetes could be greatly enhanced through the use of cutting-edge technology, enabling improved treatment recommendations, particularly for th...
Towards reversal of type 3c diabetes through anti-fibrotic therapy with marketed therapeutics
Diabetes secondary to chronic pancreatits (CP) has been relatively neglected but incidence may be as high as type 1 diabetes. It is characterised by progressive loss of β-cell func...
Scanning CONfoCal Ophthalmoscopy foR DIAbetic eye screening (CONCORDIA 2) in Asian and Afro-Caribbean Groups
Abstract Background: A study has been undertaken in Gloucestershire using a new type of Scanning Confocal Ophthalmoscope Camera (SCO - Eidon white light 60-degree field) which demo...