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606,025 grants found
Showing 27,421 – 27,440 of 606,025 grants
Short-term environmental exposures and emergency medical service activation in the U.S
PROJECT SUMMARY/ABSTRACT Emergency medical services (EMS) represent a critical facet of the public health infrastructure that will be increasingly stressed by climate change, but t...
Genetic and Epigenetic Controls of Enhancer-Promoter Interactions
Summary In vertebrates, genes directing cell-type specific programs and embryonic development are frequently controlled by cis-acting enhancers located several hundreds of kilobase...
Resource Cores for Musculoskeletal Biology Research
PROJECT SUMMARY/ABSTRACT Musculoskeletal disease and disorders affect 1 out of 2 Americans and continue to be responsible for the majority of physician/hospital visits and medical...
Administrative Core
PROJECT SUMMARY/ABSTRACTThe Administrative (ADMIN) Core will coordinate and integrate the research cores of the Indiana Center for Musculoskeletal Health-Basic Science Research Cen...
Histology and Histomorphometry Core (HHC)
PROJECT SUMMARY/ABSTRACT The Histology and Histomorphometry Core (HHC), Core B, will provide inhouse expertise, techniques, equipment, and technical innovation to facilitate ICMH i...
Systems Biology and Multi-Omics Core (SBMO)
PROJECT SUMMARY/ABSTRACT The overall goal of the Systems Biology and Multi-Omics Core (SBMOC, Core C) is to establish local infrastructure in the Indiana Center for Musculoskeletal...
Musculoskeletal Mechanobiology Core (MMBC)
PROJECT SUMMARY/ABSTRACT The mechanical environment is a foundational input to the proper development, composition, and function of the musculoskeletal system. Probing the integrit...
VCU National Coordinating Center for Advancing Gender Inclusive Excellence
PROJECT ABSTRACT/SUMMARY Background: Institutional change in higher education regarding diversity, equity and inclusion, tends to be complex, contested, and slow moving. However, m...
Predictive Gait-Based Biomarkers for Fall Risk in Lower-Limb Prosthesis Users
ABSTRACT Falls are the second leading cause of unintentional death worldwide and lower limb prosthesis users (LLPUs) constitute an exceptionally high-risk group. Over half of LLPU...
Reproductive Healthcare Deserts and Inequalities in Maternal and Infant Health
Project Summary/Abstract Access to reproductive healthcare in the U.S. has become increasingly constrained. Although a growing body of research has focused on identifying state-lev...
Biomarker-Driven Strategies to Overcome Immunotherapy Resistance in STK11-Deficient NSCLC
SUMMARY Despite significant advances in Immuno-Oncology (IO) treatments, lung cancers with loss-of-function mutations in STK11, comprising 20-30% of cases, demonstrate poor prognos...
Development of an Innovative PSMA-Targeted Small Molecule Prodrug for Prostate Cancer
ABSTRACT Prostate cancer (PCa) is the most commonly diagnosed cancer and second leading cause of cancer death in American men.1 For metastatic castration resistant prostate cancer...
New cryo-EM methods to visualize ribosome heterogeneity at single molecule resolution in cells
PROJECT SUMMARY Cryogenic electron microscopy can generate atomic resolution views of cells and is therefore a promising technology to study the molecular mechanisms underlying key...
Access to diabetic peripheral neuropathy screening for underserved communities
SUMMARY Health inequities pose serious threats to people in minority groups through exposure to greater socioeconomic risks and less access to healthcare. The economic burden of th...
Point-of-care testing for perinatal risks in early pregnancy
Background & Significance: Each year, out of 4 million pregnancies in North America, approximately 800,000 are classified as high risk. A striking 20% of these pregnancies deve...
Control of allelic Gsα expression for regulating hormone signaling
Abstract The α-subunit of the stimulatory G protein (Gsα) mediates the signaling of many hormones, autocrine/paracrine factors, and neurotransmitters. Gsα and its gene, the GNAS co...
Genetic dissection of tissue-specific roles of a circadian NADPH phosphatase
Nocturnin (NOCT) is a NADP(H) phosphatase with highly rhythmic expression peaking in the early dark phase (ZT12) in most tissues in mice. Noct-/- (Noct-KO) mice exhibit a range of...
Identifying predictive biomarkers for acute intermittent hypoxia induced motor recovery in persons with incomplete spinal cord injury
PROJECT SUMMARY Spinal cord injury (SCI) results in lifelong sensorimotor deficits, leading to chronic mobility impairments and loss of functional independence. The restoration of...
Promoting Palliative Care for People with Heart Failure: The P3HF Pilot Study
Project Summary Heart failure is a leading cause of morbidity and mortality, projected to affect more than eight million Americans by 2030. Frequent symptoms, hospitalizations, and...
Ensuring Quality in Psychological and Mental Health Services - Service User Quality Assessment EQUIP-SU
PROJECT SUMMARY/ABSTRACT There has been an increase in availability of evidence-based approaches for interventions and mental health service delivery in low-resource settings. In l...