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606,025 grants found
Showing 27,221 – 27,240 of 606,025 grants
A Motivation-Based Adolescent Vaping Typology to Inform Cessation Interventions
PROJECT SUMMARY/ABSTRACT Since the introduction of e-cigarettes in the U.S. in 2007, there has been a dramatic increase in the prevalence of e-cigarette use among adolescents. Thes...
Hybrid Effectiveness-Implementation Trial of an Executive Functioning Intervention for Children's Mental Health Services
PROJECT SUMMARY Autism is a highly prevalent neurodevelopmental condition, affecting 1 in 36 youth. The annual cost in the U.S. of autism was $223 billion in 2020 and is estimated...
Synthetic Melanin for Accelerating Wound Repair
PROJECT SUMMARY Mustard gas causes severe epithelial and deep tissue injury resulting in blisters, pain, delayed wound healing, and scarring. The complex mechanism of tissue damage...
The hemoglobin beta subunit regulates chromatin and transcription to adapt to metabolic demands
Abstract Several studies have reported that hemoglobin is expressed in neurons in the rodent and human brain, however the function of hemoglobin in these cells hasn't been cle...
ComPASS Health Equity Research Hub at Yale
ABSTRACT The Community Partnerships to Advance Science for Society (ComPASS) Health Equity Research Hub at Yale (Yale ComPASS Hub) will support select community-led health equity s...
A Superiority Trial of Radiofrequency Ablation for Low Back Pain
Low back pain is the #1 contributor to years lived with disability (CLBP; pain persisting for ≥3 months). An obstacle to reducing the societal burden of CLBP is that most treatment...
Collagen Proteostasis in Health and Disease
Collagen is the most abundant protein in animals, constituting up to one-third of total protein in humans. As the major proteinaceous component of tissues ranging from bone and ski...
Semi-supervised cross-modality translation for single-cell genomics and proteomics
Project Summary/Abstract Here, we propose a training program with two years of training to prepare the candidate for a successful transition to independence, in the field of develo...
Convergence of behavioral and sensory information in olfactory cortex
Project Summary A key function of the nervous system is to transform sensory information from the environment into actionable percepts. In a classic hierarchical representation fra...
Engineered Cytokine-Secreting Bacteria to Treat Periodontitis.
PROJECT SUMMARY. Periodontitis is one of the most prevalent diseases and a leading cause of tooth loss. In the United States, approximately 61 million adults over 30-years old have...
Functional roles of inhibitory cerebellar outputs
Project Summary/Abstract: The precision and accuracy of vertebrate movement is mediated by the cerebellum. Cerebellar damage results in a signature motor phenotype called dysmetria...
Duke-Utah HEAL KIDS Pain Resource and Data Center
PROJECT SUMMARY/ABSTRACT Thousands of children in the United States receive treatment for acute pain each year, and even more experience pain that is unrecognized. The majority of...
Better Info on Women's PrEP Choices and Outcomes in Malawi
Project Summary/Abstract The goal of this study is to understand PrEP user choices, preferences, and implementation impact of the roll- out of long-acting injectable (LAI) PrEP alo...
NEXUS: Network for Exposomics in the U.S.
PROJECT SUMMARY The Network for Exposomics in the U.S. or NEXUS is designed to advance the science of exposomics. Our team is focused on operationalizing the exposome by advancing...
Phase I Clinical Testing of a First-in-Class Therapy against Metastatic Cancer
SUMMARY Metastatic disease is responsible for ~90% of cancer deaths and is the primary determinant in the life-limiting aspect of cancer. One validated driver of metastasis is miRN...
BANFF-AID: Banff Automated Nephrology Feature Framework - Artificial Intelligence Diagnosis
Project Summary (30 lines) Banff Lesion Scores are utilized globally for assessing the condition of allografts, particularly donor kidneys. They are also used to predict the overal...
Personalized arts prescriptions for behavioral health challenges in the US
Project Summary There is an acute need to address rising mental health concerns among both older and young adults, as seen by recent increases in depression, anxiety, social isolat...
Development and Validation of a Quantitative Diagnostic Biomarker for Silent Brain Injury
PROJECT SUMMARY Alzheimer's disease (AD) is among the leading causes of death and disability worldwide with the number of patients in the US estimated to reach 16 million by 2...
Algorithm and software for predicting the structure and degrading efficiency of PROTACs
The use of PROteolysis TArgeting Chimeras (PROTACs) has become an important technology for modulating a target protein by degradation. PROTACs are heterobifunctional molecules that...
HomeLink2: Reducing posthospitalization mortality among people living with HIV through structured home care and nutritional supplementation
PROJECT SUMMARY HIV remains the leading cause of death among adults in South Africa despite the availability of antiretroviral therapy (ART) due to failure to initiate ART and fail...