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606,025 grants found
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Longitudinal assessment of the role of interoception in chemotherapy-induced peripheral neuropathy (CIPN) along the cancer chemotherapy continuum
PROJECT SUMMARY/ABSTRACT Chemotherapy-induced peripheral neuropathy (CIPN) is a severe dose-limiting toxicity that affects over 65% of patients receiving taxane- or platinum-based...
Disseminating Effective Reproductive and Sexual Health Programs
Disseminating Effective Sexual Health Programs in Schools using iCHAMPSS PROJECT SUMMARYDespite a steady decline in the U.S., teen births continue to be a public health problem, pa...
Core B - Clinical Core
PROJECT ABSTRACT – CORE B (CLINICAL CORE) The Washington University Cooperative Center on Human Immunology (WashU-CCHI) Clinical Core (Core B) combines the resources of two highly...
Core C - Proteomics Core
ABSTRACT – CORE C Core C will be responsible for the in-depth determination of the molecular composition, temporal dynamics and functional properties of the antibodies that compris...
Developing and Validating a Measure of Patient-centered Peripartum Contraceptive Care
PROJECT SUMMARY ABSTRACT Background: Contraceptive care is an essential component of maternity care. While patient-centeredness is a key aspect of the quality of contraceptive care...
Theranostic DLL3/PSMA-bi-specific CAR-T cells for prostate cancer therapy
SUMMARY Our overarching goal is to develop a novel theranostic prostate-cancer-specific CAR-T cell paradigm that will allow for successful targeting of antigen-heterogeneous neuroe...
Dynamic reprogramming of macrophage acetyl-CoA metabolism in endotoxin tolerance
PROJECT SUMMARY / ABSTRACT Macrophages play a pivotal role in maintaining homeostasis by tightly regulating the inflammatory response. In response to endotoxins like lipopolysaccha...
Role of a novel G protein-coupled mast cell receptor-mediated pathways in periodontal disease
Summary: Periodontitis is a chronic inflammatory disease in which a highly orchestrated host-microbial interaction leads to the destruction of the tooth-supporting structures inclu...
Childhood Adversity and Biological Mechanisms of Accelerated Aging
Project Summary/Abstract Early life adversity, including childhood maltreatment and other traumas, is a major risk factor for a host of health conditions, including psychiatric dis...
Multi-level mechanisms and predictors of irritability: An innovative approach bridging laboratory and real-world measures
PROJECT SUMMARY/ABSTRACT Irritability, an increased propensity to experience anger and frustration, is among the most common presenting complaints in child psychiatry. Severe irrit...
Illuminating the Molecular Logic of Mammalian Synaptic Circuit Assembly
PROJECT SUMMARY/ABSTRACT Synapses are the fundamental signaling components of the nervous system and mediate trans-neuronal information transfer. Brain functions require the precis...
Development of a highly sensitive DNA hypermethylation-based kit to identify Barrett's esophagus patients at high risk of progressing to esophageal adenocarcinoma
Summary The incidence of esophageal adenocarcinoma (EAC) has increased 600-700% in North America since the 1980s. EAC only has 18-22% of an overall 5-year survival rate because mos...
Characterizing the requirement of the mycobacterial BrkB ortholog in TB pathogenesis
Project Summary / Abstract: Due to the rise of antibiotic resistant tuberculosis and the long treatment time of current anti-tuberculosis therapies, there is an immediate need for...
Deciphering The Evolutionary and Biological Impact of Human Admixture
Project Summary Admixture is a vital evolutionary process that profoundly shapes human genetic diversity and health. Current evidence suggests that admixture is ubiquitous througho...
Inclusion of Diverse and Medically Underserved Populations in the Design and Implementation of the PREMMplus Patient-Facing App
Project Summary/Abstract The increasing use of genetic testing and the development of syndrome-specific risk models has transformed hereditary cancer risk assessment. We were funde...
Identifying ancestry-specific and distal components of disease-associated gene regulation and cellular function
Summary/Abstract Genome-wide association studies (GWAS) have associated hundreds of thousands of genetic variants with human disease and complex traits. 90% of associated variants...
Substantia nigra circuits in instrumental action
Project Summary / Abstract Degeneration of dopamine neurons in the substantia nigra pars compacta (SNc) and resulting pathophysiology in basal ganglia circuits are central to the c...
Chlamydia trachomatis manipulates (PI)CALM to carry on
PROJECT SUMMARY The CDC estimates that 10% of women between the ages of 15 to 19 test positive for Chlamydia trachomatis and 50-70% of these infections are asymptomatic. This incre...
Transcriptional profiling of proliferative skeletal muscle mononucleated cells coupled with broadband electrical cytometry towards diagnosis of myalgic encephalomyelitis/chronic fatigue syndrome
Transcriptional profiling of proliferative skeletal muscle mononucleated cells coupled with broadband electrical cytometry towards diagnosis of myalgic encephalomyelitis/chronic fa...
Preventing Adolescent Suicide Mortality: Exploring Barriers and Facilitators of School Officials' Participation in Child Death Review Meetings
Project Summary Suicide the second leading cause of death among adolescents ages 14-24; in 2022, approximately 18 adolescents died each day from suicide. Child death review (CDR) t...