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606,025 grants found
Showing 26,381 – 26,400 of 606,025 grants
Improved vaccine production by engineering the agroinfiltration platform
This proposal aims to revolutionize vaccine production in plants. Vaccines can be quickly and efficiently produced in plants through agroinfiltration of Nicotiana benthamiana to pr...
Improved vaccine production by engineering the agroinfiltration platform
Abstracts are not currently available in GtR for all funded research.This is normally because the abstract was not required at the time of proposal submission, but may be because i...
Developing, Implementing and Supporting NCI Clinical Trials and the National Cancer Trials Network (NCTN) in Breast Cancer and Developmental Therapeutics- A 5 Year Plan
Project Summary/Abstract Dr. Ciara O’Sullivan is a medical oncologist focusing on clinical and translational research in breast cancer (BC) and developmental therapeutics. Her rese...
Gynecologic cancer care: Improving clinical trial enrollment through molecular matching with targeted therapies and improving equal access to care and research for all populations
Project Summary/Abstract Gynecologic Cancer remains an underfunded area of research with funding to lethality scores significantly lower than other cancer sites. Endometrial cancer...
An Innovative Digitally-Delivered Olfactory Method for Reducing Cigarette Cravings and Supporting Smoking Cessation
ABSTRACT Cigarette smoking is the leading cause of preventable death and disability in the United States. Smoking cessation rates have stagnated in recent years, underscoring the n...
Pediatric toxoplasmosis: Addressing unmet medical need with 3D printed dose flexible delivery systems of pyrimethamine, sulphadiazine and leucovorin
ABSTRACT / PROJECT SUMMARY Toxoplasmosis is a life-threatening food-borne/congenital disease that can have severe implications in immuno-compromised children. The US Center for Dis...
A Pilot Feasibility HIV prevention Study Linking Incarcerated Women to Post-Release Pre-exposure prophylaxis (PrEP) Services
ABSTRACT This application proposes to adapt a Formerly Incarcerated Transitions (FIT) program for mostly African American women, often with health disparities, who are released fro...
Targeting GTP Cyclohydrolase 1 for treating chronic orofacial pain
PROJECT SUMMARY Chronic pain is a global healthcare problem that reduces the quality of patients’ lives and increases med- ical expenditures. Inadequate pain control with available...
Effect of the plantar skin microenvironment on tumor metastasis and drug tolerance
Project Summary Patients with advanced acral melanoma (AM) suffer worse outcomes relative to patients with cutaneous melanoma (CM), in part, because they do not respond as well to...
Impact of seizure onset pattern on temporal lobe seizure propagation through the basal ganglia
SUMMARY The objective of this proposal is to investigate how temporal lobe (TL) seizures with different onset patterns propagate through the basal ganglia (BG) and to evaluate the...
Modeling the Impact of Interventions to Reduce Typhoidal Salmonella Transmission in the Indo-Pacific.
PROJECT SUMMARY / ABSTRACT The typhoidal Salmonellas (TS), primarily Salmonella Typhi and Paratyphi A, are a major cause of global morbidity and mortality, particularly in Asia whe...
Vaccines and Therapeutic Antibodies to Respiro, Rubula, Peribunya and Phenuiviridae (R2P2)-ReVAMPP
SUMMARY. The Vaccines and Therapeutic Antibodies to Respirovirus, Rubulavirus, Peribunyavirus and Phenuivirus (R2P2) ReVAMPP Center will utilize both well-defined and novel approac...
Core A: Administrative Core
ABSTRACT – Core A: Administrative Core The Administrative Core A of the Vaccines and Therapeutic Antibodies to Respirovirus, Rubulavirus, Peribunyavirus and Phenuivirus (R2P2) ReVA...
Core B: Data Management Core
ABSTRACT Core B: Data Management Core Washington University (Miller, J. Philip) The overarching objective of the Data Management Core-B is to serve as the central hub for the analy...
Core C: Structure Core
PROJECT SUMMARY - Core C: Structure Core Structure-based vaccine antigen design is a key component of the prototype pathogen approach to pandemic preparedness. For each prototype p...
Core D: Antibody Core
ABSTRACT Core D: Antibody Core Washington University (Ellebedy, Ali) Respiroviruses, Rubulaviruses, Peribunyaviruses, and Phenuiviruses present major health burdens and have pandem...
Core E: Immunogenicity and Immune Correlates Core
ABSTRACT Core E: Immunogenicity and Immune Correlates Core (Correlates) The goal of Core E-Correlates will be to provide support to the projects by conducting various technical mea...
Prototype strategies for antibodies and vaccines for respiroviruses
Human parainfluenza virus type 3 (HPIV3) is the P1-Respiroviruses prototype for advancement of vaccines and therapeutic antibodies against respiroviruses due to the advanced state...
Prototype strategy for vaccines and antibodies to rubulaviruses
Project 2: Abstract Rubulaviruses are respiratory pathogens with a high level of transmissibility (R0 = 4-7). MuV is an ideal prototype pathogen to study paramyxoviruses because we...
Prototype strategy for vaccines and antibodies to Peribunyaviridae
SUMMARY. The long term goals of Project 3 of the Respiro, Rubula, Peribunya, Phenui (R2P2) ReVAMPP are to use a prototype pathogen approach to identify and validate generalizable v...