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606,025 grants found
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Neurotensin receptor 1 as a novel target for opioid use disorder and discovery of new small molecule probes
PROJECT SUMMARY Submitted in response to RFA-DA-24-063, we propose to develop novel, brain-penetrant, small molecule biased allosteric modulators (BAMs) of the neurotensin receptor...
Preclinical Trial: Targeting the Neuropeptide S Receptor to Curb Opioid Taking and Seeking
Summary Substance use disorders have a devastating impact on individuals, families, and society. Present pharmacological treatments do not fully ameliorate patients’ symptoms and i...
Research Administration Capacity Heightening in South Carolina (REACH-SC)
Societal shifts in work, along with the aging of the higher education workforce, are exacerbating already existing challenges in the research enterprise workforce. Emerging researc...
Elements: A Sustainable, Resource-Efficient Cyberinfrastructure for Notebook Interactive ML Training Workloads
Notebooks are general-purpose programming platforms widely used in machine learning (ML), artificial intelligence (AI), data science, and data analytics across almost every science...
Exploring the Molecular, Neuro-immune and Behavioral changes during HIV-associated progressive aging using a long-term humanized mice model
Abstract Aging is associated with persistent levels of inflammation, which is also a hallmark of HIV infection. The effects of aging are particularly important to the population of...
SBIR Phase I: The Impacts of Microgravity on Catalyst Crystallization and Performance - Ultrahigh-Throughput Investigations of Reversible Fuel Cell Catalysts
The broader impact/commercial potential of this Phase I Small Business Innovation Research (SBIR) project lies in the exploration of an entirely unexplored design knob for the prep...
Collaborative Research: EDGE FGT: In vivo and in vitro Tools for the Community of Echinoderm Researchers
Everything in biology is connected. Our job as life scientists is to reveal important biological properties in the most impactful, efficient, and economical way. To do so we look f...
Collaborative Research: Known Rivers: Creating Justice-Centered Water Literacy along the Lower Mississippi River
Marginalized communities disproportionately experience the effects of environmental degradation such as sinking infrastructure, urban flooding, and coastal land loss as a result of...
PKDNet - ARPKD Learning Network
PROJECT SUMMARY / ABSTRACT Autosomal recessive polycystic kidney disease (ARPKD) is a rare disease, affecting ~1,500 children and young adults in the U.S. In severely affected pati...
Morphogenetic mechanisms of intestinal lymphatic smooth muscle-lacteal complex function and dysfunction
ABSTRACT The lymphatic vasculature is essential for organogenesis and dietary fat absorption and the intestinal villus plays the leading role in this process. However, the developm...
Fluxomics Studies of the Effect of Diet Composition on Energy Metabolism
Obesity, a major risk factor for multiple diseases including diabetes and cardiovascular disease, has reached pandemic level and is still increasing alarmingly in the US and worldw...
Role of ULK2 in selective protein degradation and protection against sarcopenia
PROJECT SUMMARY/ABSTRACT The US population continues to age, and millions of people will likely be affected by age-related muscle atrophy and weakness (also referred to as sarcopen...
Multicolor mouse models to resolve hematopoietic stem and progenitor cells in vivo
PROJECT SUMMARY: Hematopoietic stem cells (HSCs) are at the top of a hierarchy of differentiating progenitor cells that can reconstitute the entire blood and immune system. Proper...
Cellular and molecular mechanisms governing bladder aging.
PROJECT SUMMARY / ABSTRACT Bladder conditions such as incontinence and urinary tract infections (UTI) are increasingly common with aging and driven by poorly understood changes tha...
Control of Drosophila intestinal homeostasis by RhoGap15b
Project Summary/Abstract The overall goal of this proposal is to understand how organisms as diverse as humans and the fruit flies use the same molecules to decide when and where c...
Regulation and Requirements for Coenzyme A Biosynthesis
Metabolic dysfunction-associated fatty liver disease and chronic kidney disease, affecting tens of millions of people in the US alone, exhibit pathological dysregulation of lipid m...
The Effects of the Medicaid Continuous Coverage Requirement during the Public Health Emergency on Postpartum Coverage and Maternal and Infant Care after Childbirth
PROJECT SUMMARY/ABSTRACT Career Goal: My long-time career goal is to become an independent investigator studying the effects of health care policies on access and use of maternal a...
Planning: CRISES: Building Collective Action for Sustainable Habitats
This project applies behavior science research approaches to investigate how people self-organize to manage the use of natural resources. There is a pressing need for understanding...
SBIR Phase II: Scalable Manufacturing of Supramolecular Polymers for Regenerative Medicine
The broader impact of this Small Business Innovation Research (SBIR) Phase II project is to develop a synthetic bone graft that enables safer, simpler, and lower-cost spinal fusion...
CAREER: Trustworthy Human-Centered Summarization
The rapid advancement of generative artificial intelligence and large language models is transforming how people process data, gather information, and acquire knowledge. Especially...