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606,025 grants found
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The impact of and path forward for telehealth on reducing disparities in severe maternal morbidity: A community engaged mixed-methods study
PROJECT SUMMARY The maternal mortality rate in the United States (US) is the highest among high-income countries and has been steadily rising in recent years. Near misses for mater...
Rgs7 regulation of the Kappa Opioid Receptor
The kappa opioid receptor (KOR) is part of the opioid neuromodulatory system that influences pain and mood perception. KOR agonists have been recognized for their analgesia propert...
A Longitudinal Examination of the Social and Environmental Influences on Substance Use among Non-Prescriber/Non-Executive Healthcare Workers in the United States
Healthcare workers represent a large and growing segment of the US workforce, and the strain of the COVID- 19 pandemic on the healthcare system has brought to light the significant...
MIDAS Coordination Center - Year 6-10
PROJECT SUMMARY For nearly 20-years, the Models of Infectious Disease Agent Study (MIDAS) research network has been an active community of infectious disease modeling researchers....
Pain in the Elderly: Role of Hyperalgesic Priming
Abstract Management of pain is a significant problem in the elderly, with the burden of chronic pain heavily tilted toward older adults. The high incidence of pain in the elderly h...
Developing graphene grids to overcome air-water-interface issues
SUMMARY Single particle cryoEM is now a ubiquitously employed methodology for high-resolution structure determination of biomedically important macromolecular complexes. CryoEM str...
Mitigating Delirium with Fluvoxamine Treatment for Non-Cardiac Surgery (MD FluNCS): Feasibility Trials & Mechanistic Insights
ABSTRACT The pathogenesis of postoperative delirium likely involves systemic inflammation, downstream neuroinflammation, and altered synaptic plasticity reflected by elevations in...
Acculturative stress and pro-inflammatory markers among Mexican-Origin adults with NAFLD
ABSTRACT Non-alcoholic fatty liver disease (NAFLD), an emerging risk factor for hepatocellular carcinoma (HCC), disproportionately impacts the Mexican-origin (MO) population. This...
Heavy Menstrual Bleeding Progestin Treatment in Bleeding Disorders Study
ABSTRACT Heavy menstrual bleeding (HMB) is common among adolescents and young adults with a heritable bleeding disorder (BD) and negatively impacts health-related quality of life a...
Pubovisceral muscle enthesis injury: A bioinspired approach to repair
PROJECT SUMMARY Each year, at least 20% of women who give birth vaginally sustain an avulsion of the pubovisceral muscle enthesis (PVME) at the pubic bone, substantially predisposi...
Prospective Health Impacts of Chronic Binge Eating Disorder in Hispanic Older Women Living with Food Insecurity (PROSPERA)
ABSTRACT Women live longer than men, yet they also experience greater morbidity, which makes understanding how specific chronic conditions further impact multimorbidity in women es...
The role of Brain-specific angiogenesis inhibitor 2 (BAI2) in synaptic structural organization and functional dynamics
PROJECT SUMMARY Excitatory ionotropic synapses and their associated dendritic spines play critical roles in fundamental information processing within the brain. The development and...
The CFDE Cloud Workspace
ABSTRACT The Cloud Workspace of the Common Fund Data Ecosystem (CFDE) will make it easy for a wide range of researchers to analyze data and work together. Our primary goal is to cr...
CRCNS: Assessing long-term impacts of disruption to large-scale brain networks
Large-scale complex networks support brain function across the lifespan, and features of brain networks are hypothesized to confer both vulnerability and resilience to the brain ch...
CRCNS: Mechanisms and consequences of infraslow oscillations in sleep
During sleep, the mammalian brain alternates between two major brain states, rapid eye movement (REM) and non-REM (NREM) sleep. Recent work showed that the electroencephalogram (EE...
Metal Organic Chemical Vapor Deposition for Chemically Precise Hybrid Perovskite Materials
NON-TECHNICAL SUMMARYThe growth of semiconductor materials from the vapor phase has, over the last several decades, permitted the development of advanced technologies including lig...
Measuring Digital Clinical Endpoints in Huntington's Disease (MEND-HD)
PROJECT SUMMARY (ABSTRACT) As genetic and disease-modifying interventions emerge, there is an urgent need for early and accurate assessment of disease-specific motor impairments in...
Collaborative Research: Ideas Lab: Panoramic Institutional Assessments: A Playbook for Advancing Research Capacity
This project is a collaborative effort across five Historically Black Colleges and Universities (HBCUs). The project aims to develop and pilot innovative tools and approaches to en...
Collaborative Research: Ideas Lab: HBCU Climate Action Network
This project represents a trailblazing effort to address the complex challenges of climate change through collaborative research and capacity-building activities at Historically Bl...
Cellular-level Vascular Oculomics (CVO) for monitoring systemic vascular health
Cellular-level Vascular Oculomics (CVO) for Monitoring Systemic Vascular Health . Planned activities and achievable goals: Year 1: (1.) Hardware design and implementation (Dubra/Bu...