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606,025 grants found
Showing 23,781 – 23,800 of 606,025 grants
Anga Center Community Collaborative Core
PROJECT SUMMARY East Africa is in the midst of a climate crisis as one of the most vulnerable regions of Africa to climate change (CC) and related extreme weather events (EWEs). CC...
Anga Center Capacity Building Core
PROJECT SUMMARY Residents of climate vulnerable communities—defined as those most susceptible to, or unable to cope with, adverse effects of climate change (CC), including climate...
The VA Genomics Learning Health System: Implementing genomic medicine across diverse veteran communities
PROJECT SUMMARY The Veterans Health Administration of the Department of Veterans Affairs (VA) is the largest and most diverse learning health system (LHS) in the US, caring for mor...
Empowering Interoperable Genomics-Enabled Learning Health Systems at Scale
PROJECT SUMMARY/ABSTRACT There is significant potential for patient care enabled by genomics to enable transformational improvements in health. However, the actual uptake of genomi...
Center for Climate: Equitable and Accessible Research-based Testing for Health (C-EARTH)
Climate change is increasing temperature variability and extremes, causing both direct effects on health (e.g., death, heat stress) and indirect impacts on food and water supplies....
Administrative Core
C-EARTH Administration Core Summary/Abstract: The success of the Center for Climate: Equitable and Accessible Research-based Testing for Health (C-EARTH) will depend largely on eff...
Research Project
The increasing frequency and intensity of extreme weather events, such as heat waves, is disproportionately impacting the health of racial/ethnic minority and low-income population...
Community Engagement Core
Climate change-driven heat stress is an issue of health equity, driven by lack of resources and lack of access to cooling. Community-driven cooling solutions must be at the forefro...
Implementation Solutions, and Evaluation Core
ISE Abstract Evaluation and dissemination of evidence-based solutions to mitigate the health effects of heat stress can curb the anticipated increases in heat-related morbidity and...
Making Genomic Medicine Routine in a Rural Healthcare System
Abstract The National Human Genome Research Institute’s 2020 strategic vision charts a path toward an audacious goal – that in 10-years genomic medicine will simply be medicine. To...
YOU GAVE CONSENT BUT DO I HAVE PERMISSION?
PROJECT SUMMARY/ABSTRACT Many people hesitate to contribute their biospecimens and data, including genomic data, for research because they believe that misuse is likely. Biobanks h...
Computational and Statistical Methods to determine variant effect across cell types and development stages
Project Summary Built on the success of the GTEx project, the recently launched dGTEx project will recruit 120 donors to identify genetic variants affecting gene expressions across...
Clinical Expansion of Precision Medicine in the Emergency Department
PROJECT SUMMARY Pharmacogenetic (PGx) testing may be particularly beneficial in patients who visit the emergency department (ED) because most presenting patients are experiencing s...
Small RNA Targeting Approaches to Advance Treatments for Heterotopic Ossification
ABSTRACT Heterotopic ossification (HO) is a condition involving pathologic bone formation in extra-skeletal soft tissues (e.g. tendons, ligaments, muscle) which can occur following...
A National Test of a Culturally Tailored mHealth Integrated Smoking Cessation and Mental Health Intervention for Black Adults with HIV
ABSTRACT People with HIV/AIDS (PWH) are twice as likely to smoke cigarettes compared with the general population. Further,PWH are less likely to quit smoking, likely due to barrier...
Proactive Dual-Irrigation Cardiac Chest Tube to Maintain Postoperative Patency
Abstract Over 455k cardiac procedures annually rely on chest tubes to drain blood from surgical wounds. However, dated chest drainage technologies result in significant issues—36%...
Evaluation of the Teal self-collect device for cervical cancer screening
PROJECT SUMMARY Limited access to and insufficient uptake of screening remain persistent barriers to cervical cancer elimination as a public health threat. The Teal Health self-col...
PyroTIMER Technology: Enabling T-Cell Persistence in Immunosuppressive Tumor Microenvironments
Abstract The challenge of effectively treating cancer is further complicated by the limitations of current CAR-T cell therapies, especially when confronted with the immunosuppressi...
Social determinants of health and its impact on the interconnectedness between dental and systemic disease in women
PROJECT SUMMARY The purpose of this administrative supplement proposal is to expand the studies in our parent project R03DE033541-01, Leveraging All of Us data to unravel the inter...
The role of m6A RNA methylation in C9ORF72-ALS/FTD
PROJECT SUMMARY Amyotrophic lateral sclerosis (ALS), an adult onset motor neuron degenerative disease, is increasingly recognized to have clinical, pathological and genetic overlap...