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606,025 grants found
Showing 23,741 – 23,760 of 606,025 grants
Pilot multisite randomized controlled trial of yoga to reduce depression inadolescents
PROJECT SUMMARY Even before the onset of the COVID pandemic, adolescent depression has been increasing, and health dispar- ities and disparities in access to treatment have continu...
Comprehensive Determination of Isoprostanoid Metabolism
PROJECT SUMMARY Oxidative stress (OxS) is a biochemical process that leads to damage of cellular lipids when endogenous redox homeostasis is disrupted. OxS is mechanistically linke...
Pharmacological rejuvenation of human hematopoietic stem cells
Abstract/Summary The goal of this application is to further develop a first-in-class therapeutic regimen that attenuates aging of human hematopoietic stem cells (HSCs). Aging of he...
Targeting endothelial cell metabolism to improve recovery from acute ischemic stroke in older mice.
Here we interrogate a novel therapeutic strategy for improving outcomes of acute ischemic stroke (AIS) in older mice. We will test whether amplifying endothelial cell (EC) autophag...
Viral determinants of Bacterial Vaginosis and HIV acquisition risk in the female genital tract
The female genital tract (FGT) is colonized by millions of microbial taxa that have far reaching effects on reproductive health. Resident bacteria in the FGT affect mucosal immune...
Building Healthy Habits for Heart Health
PROJECT SUMMARY Vascular calcification is the major precursor to cardiovascular disease and is further exacerbated by chronic kidney disease. Black or African Americans are more th...
Robust and precise imaging of infant brain development with magnetic resonance imaging
Project Summary/Abstract: This research proposal aims to develop advanced in vivo magnetic resonance imaging (MRI) technologies for studying infant brain development. The objective...
Guidelines for processing and storing liquid biopsy samples for functional assays in research and clinical testing.
PROJECT SUMMARY The World Health Organization predicts that cancer diagnoses will increase to 22 million per year within the next two decades, with a corresponding 70% rise in canc...
Role of Lipid Droplets in Macrophages and their Consequences in Lupus
PROJECT SUMMARY/ABSTRACT Lipid metabolism, including lipid synthesis and degradation, is essential for the immune system and cellular functions. Lipid droplets (LDs) are major lipi...
Trigeminal Nerve Stimulation for Prenatal Alcohol Exposure
ABSTRACT/SUMMARY Prenatal alcohol exposure (PAE) is a severe, life-long neurodevelopmental disorder. It afflicts hundreds of thousands of children in the US and worldwide. The high...
Transcriptional potency in early embryos
This project seeks to identify and test mechanisms that establish the transcriptional regulatory potency of early embryos. The relationships among DNA accessibility, nucleosome lab...
Implications of midlife alcohol use for risk of dementia in male and female twins: Unique contributions and interactions with APOE4
Abstract The purpose of this study is to examine alcohol consumption as a modifiable risk factor for Alzheimer's disease and related dementias (ADRD). Approximately 40% of ris...
Culturally Competent, Ethical, and Empathetic AI Police E-Trainer for Improving Non-Lethal De-Escalation Skills in a Multi-User Virtual Reality Environment to Mitigate Murders Against Black Males.
PROJECT SUMMARY/ABSTRACT Police violence against black males, in the United States (U.S.), is a public health disparity [37]. Physical & psychological violence that is structur...
Non-educational sources of later-life cognitive reserve and resilience among older adults with and without formal education in India
PROJECT SUMMARY By 2050, over 75% of cases of Alzheimer’s disease and related dementias (ADRD) are expected to occur in low- and middle-income countries (LMICs), such as India, whi...
Engaging Aging Minds: Labor Force Participation, Stimulating Activities, and Cognitive Aging Across Diverse International Settings.
PROJECT SUMMARY Alzheimer's disease and Alzheimer's disease-related dementias (AD/ADRD) present profound global challenges, particularly for rapidly aging populations in...
Guanfacine for women with AUD: A multisite study using a telehealth approach
ABSTRACT There is currently a dearth of FDA-approved medications developed specifically for women with alcohol use disorder (AUD). This represents a major public health concern for...
Effects of Pain on Laboratory Drinking Topography and Daily Drinking in People with Chronic TMD Pain
Project Summary Chronic Temporomandibular Disorder (TMD) is associated debilitating pain and dysfunction of the muscles of the jaw, the temporomandibular joints, and related struct...
Effectiveness of a multilevel integrated intervention for LDCT lung cancer screening and smoking cessation among African Americans
PROJECT SUMMARY/ABSTRACT African Americans have both the highest incidence and mortality of lung cancer compared to any other racial/ethnic group. A possible explanation for this d...
Studying Protein Affinity to DNA by in vitro Transcription and Sequencing (PADIT-seq)
PROJECT SUMMARY Sequence-specific DNA binding by transcription factors (TFs) regulates RNA synthesis at target genes. This is a highly dynamic and context-dependent process, allowi...
Feature Engineering to Infer Proteomic Changes from mRNA Data
PROJECT SUMMARY Proteins are the molecules that carry out the majority of biological function. Although mRNA levels can be measured at scale and have been transformative for unders...