Browse All Grants
20,252 grants found
Showing 2,641 – 2,660 of 20,252 grants
Overcoming resistance to KRAS inhibitors through a fragment-based chemoproteomics approach
Abstract A major breakthrough in recent years has been the development of selective inhibitors that target KRASG12C mutations found in lung, colon, and other rare cancer typ. Both...
The Impact of Biologic Aging on Immunity-Related Cervical Cancer Outcome Disparities Among Women Living with HIV in Zambia
Project Summary/Abstract Cervical cancer disproportionately affects women of color from low-socioeconomic geographical locations. Locations, such as sub-Saharan Africa, can also ha...
Process Development and Preclinical Advancement of a Novel Nanoparticle Formulation for Immune Activation
Summary Despite the success of immune checkpoint inhibitors for some types of cancer, the overall response rate remains suboptimal. The majority of solid tumors exclude T-cells (te...
Bioinformatics and Biostatistics Core
Core B: Bioinformatics and Biostatistics Core SUMMARY/ABSTRACT The primary goal of the Bioinformatics and Biostatistics Core is to provide centralized biostatistics, bioinformatics...
The role of the cohesin complex in hematopoietic transformation and leukemia maintenance
PROJECT SUMMARY In this proposal, we will define the effects of epigenetic dysregulation via Stag2 loss on three-dimensional chromatin structure and transcriptional regulation. We...
The effectiveness, cost-effectiveness, and budget impact of interventions to improve the delivery of cervical cancer screening in Puerto Rico.
PROJECT SUMMARY Cervical cancer incidence is increasing dramatically (2.5% per year) in Puerto Rico (PR), with increased occurrence of regional (1.7% per year) and distant (4.7% pe...
A digital twin to track and predict the evolution of pediatric neuroblastoma tumors
SUMMARY/ABSTRACT This application is being submitted in response to the Notice of Special Interest (NOSI) identified as NOT-CA-24-015. The proposed project aims to pioneer the deve...
Regulation of extracellular proteases in prostate cancer progression to a metastatic phenotype
No changes from the Parent (CA275846)
Examining the effect of biological sex on the tumor microenvironment and immunotherapy response
Project Summary The parent grant focuses on the genetic determinants of distinct immune microenvironments and response to immunotherapy. The objective focuses on determining the ge...
Studying the evolution of drug resistance in prostate cancer at the single cell level
PROJECT SUMMARY Patients with aggressive cancers often present with no pharmacologically actionable mutations and poor or no sensitivity to immune checkpoint blockade, thus derivin...
The SIK2 Inhibitor GRN-300 Enhances PARP Inhibitor Sensitivity and Cytotoxic T-Cell Function in Ovarian Cancer
Ovarian cancer is a significant cause of morbidity and mortality that affects nearly 300,000 women worldwide each year. Its poor outcomes relate to delayed diagnosis and developmen...
Drug Mechanism of Action-based targeting of tumor subpopulations
Patients with aggressive cancers often present with no pharmacologically actionable mutations and fail to respond to immune checkpoint blockade, thus deriving only modest improveme...
Outreach Core
Project Summary Crucial to the long-lasting impact of the Center for Cancer Systems Therapeutics (CaST) is a robust and inclusive Outreach effort. The community and computational i...
Implementation of a qPCR-based assay for the quantification of SARS-CoV-2-specific T cells in immunocompromised patients
SUMMARY Long-term protection from viral infections is mediated by both the humoral and cellular immune pathways. Multiple Myeloma (MM) is the second most common hematological malig...
Cancer Center Survivorship Research Forum
ABSTRACT The goal of this proposed biennial survivorship symposium series is to improve cancer outcomes by creating a regular forum for researchers, clinicians, and survivors to sh...
Increasing access to cancer trials in Minnesota (InACT-MN)
PROJECT SUMMARY/ABSTRACT In collaboration with the Masonic Cancer Center of the University of Minnesota, Britt Erickson, MD, has developed a research strategy that will leverage he...
Developing a culturally tailored mHealth symptom monitoring intervention to improve adherence to endocrine therapy among Black women with breast cancer
PROJECT SUMMARY Candidate Goals. My career goal is to reduce breast cancer health disparities in outcomes by addressing cancer care delivery issues in minority cancer populations....
Targeting the mutant promoter of Telomerase Reverse Transcriptase (TERT)
PROJECT SUMMARY TElomerase Reverse Transcriptase (TERT) is rate limiting in maintenance of telomere length by telomerase and also has telomere independent functions such as regulat...
Neoadjuvant immunoradiotherapy for HPV mediated oropharynx cancer
Project Summary HPV mediated oropharynx cancer (HPVOPC) is projected to increase in incidence in the United States over the next 20-years. Attempts to de-escalate nonsurgical treat...
Targeting the mutant promoter of Telomerase Reverse Transcriptase (TERT)
PROJECT SUMMARY TElomerase Reverse Transcriptase (TERT) is rate limiting in maintenance of telomere length by telomerase and also has telomere independent functions such as regulat...