Examining the effect of biological sex on the tumor microenvironment and immunotherapy response

$423.6K USD

Funder	NATIONAL CANCER INSTITUTE
Recipient Organization	Icahn School of Medicine At Mount Sinai
Country	United States
Start Date	Sep 19, 2023
End Date	Aug 31, 2028
Duration	1,808 days
Number of Grantees	2
Roles	Principal Investigator; Co-Investigator
Data Source	NIH (US)
Grant ID	`11062035`

Grant Description

Project Summary The parent grant focuses on the genetic determinants of distinct immune microenvironments and response to immunotherapy. The objective focuses on determining the genes regulating tumor composition in order to enhance tumor immunity. Similarly, this project focuses on determining the tumor microenvironment composition between males

and females before immunotherapy a critical cofactor in all our genetic analyses.