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44,293 grants found
Showing 44,081 – 44,100 of 44,293 grants
CO2 Capture directly from the atmosphere
The design of the forthcoming future is negative in emissions. Among the negative emission technologies options, those capturing CO2 directly from the air are called Direct Air Cap...
Intelligent Gas Grid
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because...
Development of Analytical Methods for the Analysis of mRNA Therapeutics
The aim of the proposed studentship is to develop and optimise novel high performance liquid chromatography (HPLC) and Mass Spectrometry methods for developing faster, robust and m...
Co-transcriptional splicing
The production of messenger RNA (mRNA) in eukaryotic cells involves precursor mRNA (pre-mRNA) synthesis and processingin particular, 5´ capping, splicing, and 3´ processing. Durin...
Towards 10-Minute Magnetic Resonance Imaging Scans in Children with Machine Learning
"1) Magnetic Resonance Imaging (MRI) has enabled significant advances in the diagnosis and management of many childhood diseases. However, MRI is challenging in the pediatric...
Identifying the DNA binding specificity of chromatin complexes in leukaemia
Leukaemia is a group of blood cell cancers. In a particularly aggressive form of this cancer, infant acute lymphoblastic leukaemia (ALL) a frequent genetic aberration involves the...
Modelling of Mosaic PIK3CA Related Overgrowth Spectrum (PROS) using induced Pluripotent Stem Cells
10 years ago a series of disorders including asymmetric tissue overgrowth was found to be caused by changes in the PIK3CA gene. The patchiness of the often life-threatening overgro...
Hierarchical turbulence and mechanical modelling of rotor-airframe interactions
Hierarchical turbulence and mechanical modelling of rotor-airframe interactions
Elucidating the role of Fam20C in microglia cells during homeostasis and neurodevelopment
This project aims to uncover the function of the secreted kinase, Fam20C, in microglia cells; and how disruption of FAM20C may lead to dysregulation of microglial function in brain...
Structural and functional connectivity in the bilingual brain across the lifespan: how experience shapes neurology and cognition
Bilingualism as an experience has the capacity to drastically change brain structure and cognition, with initial increases in grey matter, followed by increases in white matter int...
Combining Topology Optimisation and 3D Printing to Create Smart Auxetic Arterial Stents
Yet to be determined.
How does atypical protein kinase C signalling regulate actomyosin-mediated force generation in polarised cells?
Epithelial cells are polarised, and the localisation of the polarity-driving PAR complex overlaps with that of actomyosin significantly. Actomyosin's roles in contractility and cel...
The retrogenesis of self: Applying the acquisition of self in childhood to understand and address the deterioration of selfhood in dementia.
The retrogenesis of self: Applying the acquisition of self in childhood to understand and address the deterioration of selfhood in dementia
The Plight of Women: The Politics of the Memory of Resistance in Italy and France
Between 1940 and 1945, most of European countries under Nazi control saw the birth of a Resistance movement, where people rose up and fought against the German invader. Immediately...
Topological Optimisation of Electromagnetic Devices and Structures
Yet to be determined.
Regulation type I and II interferon in CD180 regulated B cells and their role in Lupus pathogenesis
The aim of this project is to understand how CD180 regulated B cells contribute to pathogenesis in lupus. We hypothesise that CD180 may function to dampen interferon signalling in...
Decoupling IFNgamma functional pleiotropy with protein engineering.
Interferon gamma (IFNgamma) is a cytokine which plays a pivotal role in antitumour host immunity. IFNgamma is a potentially useful adjuvant for cancer immunotherapy based on its ab...
Investigating the role of mTORC1 signalling in cellular migration
Rapamycin is a drug currently used to treat some cancers and to prevent organ rejection. In yeast, flies, fish and mice, rapamycin improves both healthspan and lifespan, and theref...
Target Identification of anti-cryptosporidials compounds from High throughput screenings against Cryptosporidium parvum
Cryptosporidium parvum is one of the top causative agents of diarrheal disease and malnutrition in Africa with no vaccine available and the only FDA approved drug Nitazoxanide is i...
Computational design of multi-state proteins using molecular simulations and machine learning
The ability to computationally design de novo proteins is a key technology that underpins future progress in synthetic biology and biomaterials discovery. However current de novo d...