Regulation type I and II interferon in CD180 regulated B cells and their role in Lupus pathogenesis

Funder	Medical Research Council
Recipient Organization	University of Dundee
Country	United Kingdom
Start Date	Sep 19, 2021
End Date	Sep 18, 2025
Duration	1,460 days
Number of Grantees	1
Roles	Supervisor
Data Source	UKRI Gateway to Research
Grant ID	`2609096`

Grant Description

The aim of this project is to understand how CD180 regulated B cells contribute to pathogenesis in lupus.

We hypothesise that CD180 may function to dampen interferon signalling in B cells and that is downregulation in SLE may promote TLR7 and/or other interferon regulated protein expression. To address this the first step will be to characterise the effect of type I and II interferon stimulation in B cells.

Next, we will examine the interplay between CD180 and interferon in B cells.

Finally, investigation will be carried out into the difference between CD180 positive and negative subpopulations of B cells in lupus murine models.