Development of Analytical Methods for the Analysis of mRNA Therapeutics

Funder	Engineering and Physical Sciences Research Council
Recipient Organization	University of Sheffield
Country	United Kingdom
Start Date	Jul 31, 2022
End Date	Jul 30, 2026
Duration	1,460 days
Number of Grantees	2
Roles	Student; Supervisor
Data Source	UKRI Gateway to Research
Grant ID	`2735174`

Grant Description

The aim of the proposed studentship is to develop and optimise novel high performance liquid chromatography (HPLC) and Mass Spectrometry methods for developing faster, robust and more informative (higher resolution) methods for the characterization of RNA and mRNA therapeutics.

Initial work will focus on optimising Ion Pair Reverse Phase Liquid Chromatography (IP RP HPLC) in conjunction with high temperature separations for the analysis of large RNA and mRNA therapeutics.

During the project the student will gain expertise in HPLC method development and analysis, mass spectrometry, RNA biochemistry and gel electrophoresis.