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15,626 grants found
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Functional analysis of the corticostriatal motor pathway at the single-cell level
The striatum is critical for the appropriate execution of movements and its dysfunctions cause severe motor disorders like Parkinson’s Disease.Cortical inputs activate medium spiny...
Characterization of the clinical importance of the anti-inflammatory activity of high density lipoproteins (HDL) prognostic significance, association with atherosclerotic lesion composition and identification of essential functional determinants
Bakgrund: Based on recent results from genetic studies and pharmacological intervention trials a causal relationship between plasma high density lipoprotein (HDL) cholesterol and a...
Relational Normativity
The overarching aim of the project is to make a contribution to the philosophical debate about the nature of value and morality.The contribution of the project aims to make progres...
Electronic coherence and correlation in attosecond photoionization dynamics
The emerging field of attochemistry aims at visualizing and steering chemical reactions with attosecond light pulses.However, our understanding of the ultrafast quantum dynamics in...
Mapping stress-regulated GPCRs in prefrontal cortex
Mood disorders are prevalent conditions, but efforts to develop new treatments are hindered by an incomplete understanding of their molecular and circuit-level mechanisms.At the ci...
The influence of vocal iconicity on semantic retrieval
Iconicity, i.e. form-meaning resemblance that makes /o/ sound round but /k/ sound sharp, is one of the factors that shape human language and is of import for language development a...
Changing Climate Histories: Institutionalising Swedish Transnational Climate Knowledge 1950–2000
This project historicises institutions studying climate change during the second half of the twentieth century and their role in reinterpreting and politicising the concept of ‘cli...
Interplay, stability and charge transfer dynamics at 2D transition metal dichalcogenide interfaces for solar cells
Clean energy is one of the pillars enabling a sustainable future.Solar cells with high efficiency, sourced from abundant materials, fabricated using scalable processes are meant to...
Targeting the prometastatic function of cancer-associated fibroblasts in breast cancer: the promise of inhibiting the MNK/4E signaling axis
The MNK1/2-eIF4E (MNK/4E) signaling axis is an important node of gene expression regulation in cancer cells, where it promotes selective translation of mRNAs with pro-metastatic fu...
Molecular interactions of receptor complexes regulating cell migration and axon guidance
On the surface of each cell in your body, receptors guide and regulate the cell’s function and movement, depending on the signal molecules around it.These receptors can relay signa...
Collaborative Water Governance in the European Union: A Comparison between Two Member States
Both global and European policies encourage collaborative governance to achieve sustainable use of natural resources.Due to its cross-cutting nature, water governance is a prime ex...
Reading Art Worlds in Small Print: Prismatic Combinations of Literature and Visual Art in South African Little Magazines 1960s to 1970s
Over two years, I will investigate the various forms that encounters between writers and visual artists take within the pages of local small-scale periodicals or “little magazines”...
Understanding the past to predict the future: the evolution of butterfly-plant networks and its implications for the future of European butterfly biodiversity in a changing climate
Global change is rapidly restructuring habitats and landscapes across the world. With such change, we are also changing the availability of resources for millions of species.The re...
The Rural Working Poor in Sweden, 1300–1600
This project aims at studying how coercive labour institutions structured the rural economy in medieval and early modern Sweden, and will answer the questions of how such instituti...
MachMe-in-Time: Evolution of DNA Methylation Machinery and Function across Time
The basal unit of biological information is the DNA sequence. Furthermore, DNA nucleotides can be methylated, impacting genome structure and readout.DNA methylation can be epigenet...
Mismatch: A novel explanation for the decline in co-residential partnerships in the Nordic countries
Couple co-residence is declining in Finland and Sweden. In particular, increasingly, less well-off individuals are not sharing a household with their romantic partners. Why is this...
An evolutionary model for human-specific vulnerabilities in dopaminergic neurons
The human brain has evolved remarkable cognitive and social abilities over the last 6 million years, but these adaptations involved trade-offs that may leave us more vulnerable to...
Illuminating Genome Architecture in Health and Disease
The three-dimensional (3D) architecture of the genome is emerging as a novel target for anti-cancer therapy.The overarching goal of this project is to deepen our knowledge on force...
Biomimetic Materials for Personalised Bone Regeneration
Fractures are common traumatic injuries during the entire human history. Worldwide more than 20 million patients are annually affected by a loss of bone tissue caused by trauma or...
Computational Astrobiology: The Rise of Macromolecules
The goal of this project is to enhance our knowledge of chemical structures and processes that may play a role in life’s possible origins.We will apply quantum chemical calculation...