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15,626 grants found
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Chronic Stress: National collaboration for evidence-based care
Stress-related disorders are amongst the leading causes of sick-leave in several countries. Still, there is little consensus on how chronic stress should be diagnosed, measured, an...
Mouth work-out to prevent malnutrition and sarcopenia
Ageing causes reduction in muscle mass and strength including the muscles responsible for chewing and swallowing movements.Older people with chewing and swallowing problems often c...
Efficacy, tolerability and preferences of per oral or subcutaneous methotrexate in patients with early rheumatoid arthritis – a randomised register based multicentre study
Rheumatoid arthritis (RA) is an inflammatory rheumatic disease that mainly affects the joints, but also affect other organs. Delayed or insufficient treatment can lead to joint des...
Registry-randomized study to reduce the risk of heart failure in patients with atrial fibrillation
The most common and a potentially fatal consequence of atrial fibrillation in the long-term is the development of heart failure.The association between atrial fibrillation and f he...
NOVEL STRATEGIES FOR ENHANCING UPPER LIMB FUNCTION AFTER CERVICAL SPINAL CORD INJURY
Tetraplegia after a cervical spinal cord injury (C-SCI) often result in lifelong dependence.Tendon transfer surgery has proven successful in restoring grip functions, which improve...
The Role of Mast Cells in Atherosclerotic Plaque Calcification
Background: Calcification is a key feature of atherosclerosis and has been associated with major adverse cardiovascular events. Unstable carotid plaques cause stroke and lesions fr...
Filovirus interactions on the cell surface: finding the sweet spots
The filoviruses Ebola and Marburg are among the most deadly human pathogens, which motivates a comprehensive understanding of their biology and pathogenicity towards the developmen...
Tick-borne encephalitis (TBE) – understanding a complex disease from a detailed immunological and virological standpoint
Tick-borne encephalitis virus (TBEV) is the causative agent of tick-borne encephalitis (TBE).TBEV-infection can result in severe pathological consequences with meningitis and encep...
Mastceller och deras progenitorer vid astma - markörer av sjukdomssvårighet och bidrag till luftvägsöverkänslighet?
Bakgrund: Mastceller spelar en nyckelroll vid allergiska reaktioner genom IgE-medierad aktivering och frisättning av t.ex. histamin och tryptas. Humana mastceller utvecklas från ma...
A Breath Test - a new diagnostic method for acute and chronic lung rejection after lung transplantation
Bakgrund: Lung transplantation (LTx) is the only effective treatment for patients with end stage lung disease. Despite improvements in LTx, primary graft dysfunction (PGD) and chro...
Molekylära och bildgivande tekniker för kardiovaskulär riskbedömning
Bakgrund:Bakgrund: Ateroskleros, med inflammation som en betydelsefull faktor, är via akut koronarsyndrom eller stroke en viktig morbiditets- och mortalitetsorsak i västvärlden. CO...
Novel immunological mechanisms and direction for new immunological therapies with focus on small lipid antigens
BackgroundWe demonstrated that oxidized LDL (oxLDL) cause dendritic cell (DC) and T cell activation in atherosclerotic plaques and that a small lipid-related antigen, phosphorylcho...
An “Attack on the Separation of Powers”? The Legitimacy of Climate Change Litigation in Global Climate Governance. A case study of judges’ arguments in the United States
Pointing to climate change related injury, citizens are increasingly turning to courts in order to take legal action against their governments. Some lawsuits, such as Juliana v. Un...
Identification and clinical development of biomarkers for improved diagnosis and therapy monitoring in patients with asthma
Bakgrund:Behandlingen av astma sker idag framför allt utifrån symtombild och historik av exacerbationer, men intresset för biomarkörer har ökat kraftigt på senare år. Den kliniskt...
Sensory biases in nonverbal communication
The voice conveys a wealth of information about the speaker’s age, dominance, emotional state, etc.Despite great progress in describing how this information is encoded acoustically...
A new approach for PET quantification using multilevel Bayesian modelling, and its application to study the neurobiology of depression
Depression is suffered by over 264 million people, and is one of the leading causes of disability worldwide.Positron emission tomography (PET) is an in vivo imaging method essentia...
The Classics are Merely Footnotes to My mind: Neo-Confucianism as Religious and Pedagogical Practice
The project critically investigates the notion of Confucianism as a philosophy.That the notion is inappropriate becomes clear when studying the Wang Yangming movement in 16th centu...
Elucidating the mechanisms of Autoimmune Hepatitis
We created a Traf6ΔTEC mouse in which aberrant central tolerance in the thymus leads to production of autoreactive T cells and spontaneous liver autoimmune hepatitis (AIH). In this...
Measuring the electron´s electric dipole moment using ultracold molecules
New fundamental particles at high energy scales that have not been reached by the Large Hadron Collider (LHC) could explain the observed matter-antimatter asymmetry that cannot be...
Death in Transition: Changing Burial Practices in a Late Roman World (c. 250–600 CE)
The purpose of ‘Death in Transition’ is to change how we perceive and study historical transformation through highlighting their complexity.The project aims to challenge the common...