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15,626 grants found
Showing 561 – 580 of 15,626 grants
Regeneration of the dorsal column tract in chronic spinal cord injury.
Spinal cord injuries pose significant challenges as there are currently no effective therapeutic interventions available, leading to irreversible functional deficits.While peripher...
PROTACs - A novel strategy for the treatment of Alzheimer disease
The presence of β-amyloid plaques and neurofibrillary tangles of tau are two main pathological hallmarks of Alzheimer disease (AD).Lowered efficiency of degradation pathways, such...
CAL Sub-phenotypes: A Systems Medicine Framework for Investigating Molecularly & Mechanistically Distinct Groups with Chronic Airflow Limitations (CAL) in Never-smokers
Chronic airflow limitations (CAL), which includes Chronic obstructive pulmonary disease (COPD), is a global health problem affecting 10% of the population, 20% of which have never...
Astrocytes: a potential target to reduce cell-to-cell spreading and chronic inflammation in Alzheimer’s disease
Decades of research have focused on neuronal abnormalities during Alzheimer’s disease (AD) progression, while glial cells, including astrocytes, have been given much less attention...
Exploring therapeutic opportunities in the recurrent brain tumor microenvironment
Gliomas are the most common primary brain tumors and the highest-grade glioma, glioblastoma (GBM), is arguably the most aggressive tumor type, with virtually no long-term survivors...
Testosterone regulation of human immunity
Immune-mediated diseases exhibit marked sex bias.Although men present with more severe infections and have lower vaccine responses, treatment strategies still neglect biological se...
Needs-based school funding - a path to improving student achievement and reducing educational inequalities?
The project will study the effects of needs-based school funding on students’ educational paths, using hand-collected data from all Swedish municipalities and comprehensive, high-q...
EduWell: Education for Health and Learning
The overall purpose of the researchnetwork EduWell is to explore, explain, compare and develop school health education in Sweden, Finland, Norway and Iceland. Young people´s mental...
Tumor microenvironment biomechanics studied with microscale acoustofluidics
We aim to investigate, modify and quantify biomechanical properties in tumor-on-a-chip spheroids and organoids, focusing on the cellular and sub-cellular length scale within the tu...
Brightening the Universe: New Directions for Astrophysical Axion Searches
The nature of dark matter and what lies beyond the Standard Model (SM) of particle physics are among the most profound unanswered questions in fundamental physics.We propose a pion...
Precision treatment of type 2 diabetes based on the beta-cell phenotype
What defines the dysfunction of the insulin-secreting beta-cells in type-2 diabetes (T2D)? This question is central to the understanding of the causes, treatment and prevention of...
CD69 PET of activated immune cells in immunotherapy
The advent of immunotherapy has revolutionized cancer treatment, yet its effectiveness varies widely among patients, underscoring the need for better diagnostic tools to guide ther...
Mechanisms of plasmid copy number control in bacterial pathogenesis and antibiotic resistance
Plasmids often encode virulence determinants and multi-antibiotic resistance.Previously, we established that up-regulation of plasmid copy number (PCN) is an essential virulence me...
Optimization of the management and timing of surgery of patients with bicuspid aortic valve stenosis to prevent complications
Stenosis of the aortic valve is the most common valvular disorder in the western world.The bicuspid aortic valve (BAV), where the aortic valve have two instead of three leaflets, i...
Mapping context sensitive properties of Kv channels to improve selective drug design
Current treatments do not provide sufficient relief for up to 30% of those suffering from excitability conditions such as cardiac arrhythmias and epilepsy.Voltage-gated potassium (...
Regulation of Memory B cells During Vaccination
Vaccines are still lacking against genetically variable pathogens including HIV-1 and hepatitis C virus, and potent vaccines are also lacking against other viral pathogens includin...
Targeting dysregulated basal ganglia output in Parkinson’s disease.
The motor symptoms of Parkinson’s disease (PD) originate from dysfunctions in the basal ganglia, triggered by a reduction in dopaminergic tone. Dopaminergic therapy is effective in...
Why must I feel sick? The benefits of sickness behavior in the defense against pathogens
Everyone has experienced sickness behavior during an infection: feeling fatigued, having little appetite, wishing to stay alone, lacking motivation, and maybe even feeling depresse...
Synaptic connectome maladaptation in the circuits of innate fear
Mental disorders account for 30% of the global disease burden. Anxiety disorders represent the highest proportion with conditions such as post-traumatic stress disorder (PTSD). Wom...
Flavor and CP from beyond the electroweak scale
This project aims to develop extensions of the Standard Model of particle physics based on strongly coupled gauge theories, positing the Higgs boson as a composite particle.Buildin...