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606,025 grants found
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The role of underheated homes in preschool respiratory infections: A national epidemiological and natural experiment study using linked data.
Acute respiratory infections (ARIs) are the main cause of hospitalisations in preschool children and increase the risk of asthma and premature adult death.ARIs are associated with...
Lipid homeostasis disruption in DYT-TOR1A dystonia
Dystonia is the third most common movement disorder characterised by painful involuntary muscle contractions that disrupt coordinated locomotion.However, the neuronal dysfunction t...
Assessing the potential epidemiological impact and cost-effectiveness of a status-neutral HIV care approach integrated with other sexual health services for adolescents and young adults in South Africa: a mathematical modelling study
In South Africa, despite freely available and effective HIV treatment and prevention, 210,000 new infections and 51,000 deaths occurred in 2021.Sexually active adolescents and youn...
From novel biology to clinical strategy: Targeting the M5-muscarinic acetylcholine receptor in opioid addiction
The world is facing an opioid crisis of epidemic proportion.Within the United States >4% of the adult population currently misuse prescription opioid analgesics whilst in the UK...
Centromeric Recombination: friend or foe?
Accurate cell division is imperative for organism development, At the heart of this critical process lie the centromeres, pivotal in orchestrating kinetochore assembly and ensuring...
Clonal and functional T cell determinants of protection and pathogenesis in tuberculosis.
Tuberculosis (TB), resulting from infection with Mycobacterium tuberculosis (Mtb), kills 1.5 million people per year.The immune system prevents disease in most people who become in...
Olfactory communication in the first weeks of life: from chemical mechanisms to improving breastfeeding outcomes
Successfully latching onto the mother's breast is critical for infant survival, growth, and health, while also enhancing bonding and maternal wellbeing.However, breastfeeding...
Optical Functional Imaging For Metabolic Cell Model Engineering and Profiling
Spatial-temporal regulation of cell-signalling, and metabolism is crucial to maintain function within cells and tissues.In this proposal we will develop advanced microscopical tool...
CAREER: CritComp Pop-Ups: A Research-Practice Partnership for Co-Designing and Implementing Critical Computing Elementary Education Curricula
Elementary school-aged children use and have interest in technologies with integrated AI applications, yet they rarely critically investigate the sociopolitical contexts in which p...
Multimodal, multiscale functional tissue state imaging
Human biology is highly complex and despite advances in technology development, we lack an understanding of how the many thousands of molecules and features of a cell make up a tis...
RNA-based cancer ImmunotheraPeutics to Enhance CROssPrimming (RIPECROP)
Cancer immunotherapy achieves unprecedented efficacy against a number of malignant diseases.Preclinical experiments in mouse models conclude that type-1 dendritic cells (cDC1) that...
Dunhill Medical Trust Doctoral Training Programme for Ageing Research
The DTP for Ageing Research in Exeter will focus on two main areas and here we provide examples of potential PhD projects. (1) Improving our understanding of the mechanisms of agei...
DISES Investigating mercury biogeochemical cycling via mixed-methods in complex artisanal gold mining landscapes and implications for community health
Human activities lead to increased contamination in both terrestrial and aquatic ecosystems. Contaminants can pose harm to both people and wildlife, with specific harms and exposur...
Collaborative Research: EAGER: AI-Assisted Just-in-Time Scaffolding Framework for Exploring Modern Computer Design
There is a need to train skilled computer architects to design innovative computer hardware. Software-based simulation is the backbone of computer system design and development. Su...
CAREER: Vivificando Valores Incluyentes Radicalmente en la Educacion de Ingenieria (ViVIR): Inspiring Radically Inclusive Values in Engineering Education
Many researchers have established that groups Historically Minoritized and Marginalized (HMM) in STEM (e.g., women, Hispanic, Indigenous, Black) tend to place greater importance on...
CAREER: Ultrasensitive Multiplex Nanopore Biosensing for Point-of-Care Testing of Infectious Diseases
The ongoing global pandemic of COVID-19 has reminded us the importance of diagnostic testing technologies. Current point-of-care testing (POCT) technologies are inexpensive and eas...
IIBR RoL: Collaborative Research: A Rules Of Life Engine (RoLE) Model to Uncover Fundamental Processes Governing Biodiversity
An unprecedented opportunity to advance understanding of the biological rules that govern the diversity and dynamics of life now exists thanks to the large quantity and variety of...
Collaborative Research: FMitF: Track I: Synthesis and Verification of In-Memory Computing Systems using Formal Methods
This project is a collaborative effort that brings together expertise in formal methods, machine learning, computer-aided design, and fabrication of in-memory computing systems. Th...
Collaborative Research: SWIFT: MEDUSA: Mid-band Environmental Sensing Capability for Detecting Incumbents during Spectrum Sharing
Spectrum sharing in mid-band offers unprecedented opportunity to harness desirable frequencies for commercial 5G operators and for unlicensed use, although higher priority incumben...
Collaborative Research: CCRI: ENS: Boa 2.0: Enhancing Infrastructure for Studying Software and its Evolution at a Large Scale
In today’s software-centric world, ultra-large-scale software repositories, e.g. GitHub, with hundreds of thousands of projects each, are the new library of Alexandria. They contai...